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公开(公告)号：KR1020040080160A
公开(公告)日：2004-09-18
申请号：KR1020030015037
申请日：2003-03-11
Applicant: 재단법인서울대학교산학협력재단
Abstract: PURPOSE: Provided is a scalaraminal compound which has excellent antibiotic activity and stability. A process for preparing such compound from a poriferan is also provided. CONSTITUTION: The scalaraminal compound is represented by the formula 1, and is prepared by the process comprising the steps of: lyophilizing a poriferan to completely remove the moisture therefrom; extracting the lyophilized poriferan with methanol and dichloromethane; evaporating the solvents under the reduced pressure; fractionally extracting the obtained residue with methanol and n-hexane; evaporating the resulting methanol layer; fractionally extracting the obtained residue with ethylacetate and water; and purifying the resulting ethylacetate layer using a chromatography.
Abstract translation: 目的：提供具有优异抗生素活性和稳定性的标量化合物。 还提供了一种从苜蓿粉制备这种化合物的方法。 构成：标量化合物由式1表示，并且通过包括以下步骤的方法制备：冻干罂粟籽以从其中完全除去水分; 用甲醇和二氯甲烷萃取冻干的poriferan; 在减压下蒸发溶剂; 用甲醇和正己烷分馏得到的残渣; 蒸发所得甲醇层; 用乙酸乙酯和水分级提取所得残余物; 并使用色谱法纯化所得的乙酸乙酯层。
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公开(公告)号：KR1020090060787A
公开(公告)日：2009-06-15
申请号：KR1020070127723
申请日：2007-12-10
Applicant: 재단법인서울대학교산학협력재단
IPC: A01N63/00
CPC classification number: A61K31/7076 , C07H19/167
Abstract: A novel sorangiadenosine compound having antibacterial activity, which is isolated from a Sorangium cellulosum is provided to have inhibition activity against gram-positive bacteria and gram-negative bacteria and treat disease caused by bacterial infection. A novel sesqui-terpene adenoside compound of the general formula I is isolated from a Sorangium cellulosum. In the general formula I, R1-R11 are independently hydrogen, halogen group, nitro group, amine group, hydroxyl group, C1-C5 low alkoxyl group, sulfhydryl group, sulfonyl group, carboxyl group, C1-C5 low alkyl ester group, C1-C20 alkyl group, C2-C20 alkenyl group or C2-C20 alkynyl group. A antibacterial composition for treating disease caused by bacterial infection comprises a sorangiadenosine compound of the general formula I and its pharmaceutically allowable salt. The disease caused by bacteria infection is staphylococcus food poisoning, cellubitis, scull furnace infection meningitis, peritonitis, cystitis, lymphangitis, panaritium, tympanitis, and respiratory disease.
Abstract translation: 提供具有抗菌活性的新颖的具有抗菌活性的山梨酸腺苷化合物，其从纤维素酵母中分离，以对革兰氏阳性细菌和革兰氏阴性细菌具有抑制活性并治疗由细菌感染引起的疾病。 通式Ⅰ的新型倍半萜类腺苷化合物是从纤维素中分离的。 在通式Ⅰ中，R1-R11独立地为氢，卤素基，硝基，胺基，羟基，C1-C5低级烷氧基，巯基，磺酰基，羧基，C1-C5低级烷基酯基，C1 -C 20烷基，C 2 -C 20烯基或C 2 -C 20炔基。 用于治疗由细菌感染引起的疾病的抗菌组合物包含通式I的山梨酸腺苷化合物及其药学上可允许的盐。 由细菌感染引起的疾病是葡萄球菌食物中毒，纤维蛋白溶解症，脊髓炎感染脑膜炎，腹膜炎，膀胱炎，淋巴管炎，泛黄，鼓膜炎和呼吸系统疾病。
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公开(公告)号：KR1020050017077A
公开(公告)日：2005-02-21
申请号：KR1020030056204
申请日：2003-08-13
Applicant: 재단법인서울대학교산학협력재단
IPC: A01N31/06
Abstract: PURPOSE: Provided is an antibacterial composition which contains novel antibacterial compounds including periconicin A and B produced from Periconia minutissima. Therefore, the composition is useful for treatment of infectious diseases. CONSTITUTION: The novel periconicin derivatives are represented by the formula(I), wherein R1 and R2 are independently methyl group or hydroxy methylene group. The derivatives include periconicin A and B. The antibacterial composition contains the compound of the formula(I) and a pharmaceutically acceptable carrier.
Abstract translation: 目的：提供一种抗菌组合物，其包含由Periconia minutissima产生的包含periconicin A和B的新型抗菌化合物。 因此，该组合物可用于治疗感染性疾病。 构成：新颖的periconicin衍生物由式（I）表示，其中R 1和R 2独立地是甲基或羟基亚甲基。 衍生物包括孔雀绿素A和B.抗菌组合物含有式（I）的化合物和药学上可接受的载体。
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Patent Agency Ranking
公开(公告)号：KR100962843B1
公开(公告)日：2010-06-10
申请号：KR1020070127723
申请日：2007-12-10
Applicant: 재단법인서울대학교산학협력재단
IPC: A01N63/00
Abstract: 본 발명은 점액세균(Sorangium cellulosum)으로부터 분리한 항균 활성을 갖는 신규 화합물 및 이를 유효성분으로 함유하는 항균조성물에 관한 것으로, 상세하게는 점액세균(Sorangium cellulosum)의 배양액에서 세스퀴테르펜 아데노사이드계 화합물인 신규 소란지아데노신 화합물을 분리하여 다양한 그램양성 및 그램음성 박테리아에 대한 강한 저해활성을 확인함으로써, 이를 포함하는 조성물은 세균 감염성 질병의 치료를 위한 조성물로 유용하게 이용될 수 있다.
소란지아데노신, 세스퀴테르펜 아데노사이드, 점액세균, 항균조성물-
公开(公告)号：KR100835677B1
公开(公告)日：2008-06-09
申请号：KR1020070003480
申请日：2007-01-11
Applicant: 재단법인서울대학교산학협력재단
IPC: A01N63/02
Abstract: A halisulfate compound isolated from Hippospongia sp. is provided to inhibit isocitrate liase(ICL) and appressorium formation by Magnaporthe grisea and show inhibitory effect on Magnaporthe grisea infection, thereby being used as a fungicidal composition for controlling harmful fungi. A fungicidal composition for controlling Magnaporthe grisea comprises a halisulfate 1 compound isolated from Hippospongia sp. and represented by a formula(1) as an effective ingredient.
Abstract translation: 从Hippospongia sp。分离出的硫酸氢盐化合物 被提供用于抑制稻瘟病菌的异柠檬酸顺铂（ICL）和形成，并且对稻瘟病菌感染具有抑制作用，因此用作防治有害真菌的杀真菌组合物。 用于控制稻瘟病菌的杀真菌组合物包含从Hippospongia sp。分离的卤代硫酸盐1化合物。 并由式（1）表示为有效成分。
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6.发明授权오돈탈리아 코림비퍼러로부터 분리된 브로모페놀 화합물을함유하는 살진균용 조성물 失效包含从臭椿OUND OUND OUND ING ING ING ING ING A A A A A A A A A A A A A A A A A A A A A
公开(公告)号：KR100826663B1
公开(公告)日：2008-05-02
申请号：KR1020070018063
申请日：2007-02-22
Applicant: 재단법인서울대학교산학협력재단
Abstract: A fungicidal composition comprising bromophenol compounds isolated from Odonthalia corymbifera is provided to inhibit activity of isocitrate lyase(ICL), appressorium formation of Magnaporthe grisea, and infection of rice blast disease without side effects, so that the composition is useful for control of harmful fungi. A fungicidal composition for controlling Magnaporthe grisea comprises bromophenol compounds represented by the formula(1), isolated from Odonthalia corymbifera, wherein R1 and R2 are each independently hydrogen atom, hydroxy group or bromo group; R3 is C1-C6 linear or branched alkyl group, alkenyl group, alkynyl group or alkoxy group which is optionally substituted by R'; R' is hydrogen atom, hydroxy group, nitro, halogen, amine, C1-C4 lower alkyl, C1-C4 lower alkenyl group or C1-C4 lower alkoxy group; and the bromophenol compounds include 3,5-dibromo-4-hydroxyphenylethylamine, 2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, 2,3-dibromo-4,5-dihydroxybenzyl alcohol, 2,3-dibromo-4,5-dihydroxybenzyl methyl ether, 2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-hydroxymethyldiphenylmethane and 3-bromo-4-(2,3-dibromo-4,5-dihydroxybenzyl)-5-methoxymethylpyrocatechol. Further, the Magnaporthe grisea comprises Magnaporthegrisea, Bipolaris, Drechslera or Rhizoctonia solani(Mananporthe grisea).
Abstract translation: 提供了包含从Odonthalia corymbifera分离的溴酚化合物的杀真菌组合物，用于抑制异柠檬酸裂解酶（ICL）的活性，稻瘟病菌的形成和稻瘟病的感染，而没有副作用，因此该组合物可用于控制有害真菌。 用于控制稻瘟病菌的杀真菌组合物包含由分子式（1）表示的溴酚化合物，其分离自Odonthalia corymbifera，其中R 1和R 2各自独立地为氢原子，羟基或溴基; R3是任选被R'取代的C1-C6直链或支链烷基，烯基，炔基或烷氧基; R'是氢原子，羟基，硝基，卤素，胺，C1-C4低级烷基，C1-C4低级烯基或C1-C4低级烷氧基; 溴酚化合物包括3,5-二溴-4-羟基苯乙胺，2,2'，3,3'-四溴-4,4'，5,5'-四氢二苯基甲烷，2,3-二溴-4,5-二羟基苄基 醇，2,3-二溴-4,5-二羟基苄基甲基醚，2,2'，3-三溴-3'，4,4'，5-四羟基-6'-羟甲基二苯基甲烷和3-溴-4-（2 1,3-二溴-4,5-二羟基苄基）-5- methoxymethylpyrocatechol。 此外，Magnaporthe grisea包括Magnaporthegrisea，Bipolaris，Drechslera或Rhizoctonia solani（Mananporthe grisea）。
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公开(公告)号：KR1020050096063A
公开(公告)日：2005-10-05
申请号：KR1020040021328
申请日：2004-03-29
Applicant: 재단법인서울대학교산학협력재단
IPC: A61K31/277
Abstract: 본 발명의 아크릴 유도체 화합물들은 소르타제 효소를 탁월하게 억제하므로 내성균주에 의한 각종 세균 감염증 질환의 치료 및 예방에 효과적이므로 기존 항균제에 내성을 갖는 세균감염증 치료에 효과적인 의약품의 제조에 유용하게 사용할 수 있다.
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公开(公告)号：KR100507041B1
公开(公告)日：2005-08-08
申请号：KR1020030056204
申请日：2003-08-13
Applicant: 재단법인서울대학교산학협력재단
IPC: A01N31/06
Abstract: 본 발명은 신규한 항생물질 및 이를 함유하는 항균조성물에 관한 것으로, 상세하게는 주목나무 내피의 식물 내생진균인 페리코니아 미누티시마(
Periconia minutissima ) 진균이 생산하는 항균성 항생물질인 신규 디테르펜계 화합물인 페리코니신(periconicin) A, B 및 이를 함유하는 항균 조성물에 관한 것이다.
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