公开(公告)号：KR1020090093702A

公开(公告)日：2009-09-02

申请号：KR1020080019389

申请日：2008-02-29

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  최상현 ,  안광진

IPC: B82B3/00 ,  B82Y40/00 ,  B82Y30/00

CPC classification number: C01B13/14 ,  B22F9/24 ,  B22F2301/15 ,  B22F2301/255 ,  B22F2304/054 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2004/64

Abstract: A method for manufacturing a metal oxide-metal heterojunction nanoparticle is provided to vary the shapes of metal oxide-metal heterojunction nanoparticles such as a dumbbell shape and a flower shape. A method for manufacturing a metal oxide-metal heterojunction nanoparticle comprises the following steps of: mixing a metal precursor solution and an organic acid metal salt composite solution, wherein the metal precursor solution consists of a metal precursor, a surfactant and an organic solvent and the organic acid metal salt composite solution consists of an organic acid metal salt composite, the surfactant and the organic solvent; and pyrolyzing the mixture. The metal precursor is selected from the group consisting of HAuCl4.nH2O, H2PtCl6.nH2O, NiCl2 and AgNO3. The surfactant is selected among C1-C18 alkyl amines.

Abstract translation: 提供金属氧化物 - 金属异质结纳米颗粒的制造方法，以改变金属氧化物 - 金属异质结纳米颗粒的形状，例如哑铃形状和花形状。 金属氧化物 - 金属异质结纳米颗粒的制造方法包括以下步骤：将金属前体溶液和有机酸金属盐复合溶液混合，其中金属前体溶液由金属前体，表面活性剂和有机溶剂组成， 有机酸金属盐复合溶液由有机酸金属盐复合物，表面活性剂和有机溶剂组成; 并热解混合物。 金属前体选自HAuCl4.nH2O，H2PtCl6·6H2O，NiCl2和AgNO3。 表面活性剂选自C1-C18烷基胺。

公开(公告)号：KR1020080071472A

公开(公告)日：2008-08-04

申请号：KR1020070077029

申请日：2007-07-31

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  나현빈 ,  안광진

IPC: A61K49/08 ,  A61K49/10 ,  A61K49/06 ,  B82Y5/00

Abstract: A method for producing an MRI(magnetic resonance imaging) T1 contrasting agent comprising manganese oxide nanoparticle is provided to obtain enhanced fine image as compared to the conventional T1-weighted image, and diagnose and treat cancers by conjugating a cancer marker with the manganese oxide nanoparticle. A method for producing an MRI T1 contrasting agent comprising manganese oxide nanoparticle comprises the steps of: (i) pyrolyzing Mn-C4-25 carboxylate complex to prepare manganese oxide nanoparticles having diameter of 35 nm or less, dispersed in an organic solvent selected from C6-26 aromatic hydrocarbon, C6-26 ether, C6-25 aliphatic hydrocarbon, C6-26 alcohol, C6-26 thiol and C6-25 amine; and (ii) coating the manganese oxide nanoparticles with a biocompatible material selected from polyvinylalcohol, polylactide, polyglycolide, poly(lactide-co-glycolide), polyanhydride, polyester, polyetherester, polycaprolactone, polyesteramide, polyacrylate, polyurethane, polyvinyl fluoride, poly(vinyl imidazole), chlorosulphonate polyolefin, polyethylene oxide, poly(ethylene glycol) and dextran. Further, a thickness of the poly(ethylene glycol) is 5 to 10 nm.

Abstract translation: 提供了包含氧化锰纳米颗粒的MRI（磁共振成像）T1对比剂的制造方法，以与常规T1加权图像相比获得增强的精细图像，并通过将癌症标记物与氧化锰纳米颗粒结合来诊断和治疗癌症 。 制备包含氧化锰纳米颗粒的MRI T1对比剂的方法包括以下步骤：（i）热解Mn-C4-25羧酸盐络合物以制备直径为35nm或更小的氧化锰纳米颗粒，其分散在选自C6的有机溶剂中 -26芳烃，C6-26醚，C6-25脂族烃，C6-26醇，C6-26硫醇和C6-25胺; 和（ii）用选自聚乙烯醇，聚丙交酯，聚乙交酯，聚（丙交酯 - 共 - 乙交酯），聚酐，聚酯，聚醚酯，聚己内酯，聚酯酰胺，聚丙烯酸酯，聚氨酯，聚氟乙烯，聚（乙烯基） 咪唑），氯磺酸盐聚烯烃，聚环氧乙烷，聚（乙二醇）和葡聚糖。 此外，聚（乙二醇）的厚度为5〜10nm。

公开(公告)号：KR1020080071463A

公开(公告)日：2008-08-04

申请号：KR1020070009707

申请日：2007-01-30

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  이정희 ,  나현빈 ,  안광진

IPC: A61K49/08 ,  A61K49/06 ,  A61K49/10 ,  B82Y5/00

Abstract: An MRI(magnetic resonance imaging) T1 contrasting agent comprising manganese oxide nanoparticles is provided to enhance image resolution as compared to the conventional T1-weighted image, show cell distribution by improving cell-penetrating ability and minimize side effects. An MRI T1 contrasting agent comprises manganese oxide nanoparticles which are coated by a biocompatible material selected from polyvinylalcohol, polylactide, polyglycolide, poly(lactide-co-glycolide), polyanhydride, polyester, polyetherester, polycaprolactone, polyesteramide, polyacrylate, polyurethane, polyvinyl fluoride, poly(vinyl imidazole), chlorosulphonate polyolefin, polyethylene oxide, poly(ethylene glycol) and dextran, and have particle size of 50 nm or less, preferably 40 nm or less, or more preferably 35 nm or less. Further, a thickness of the poly(ethylene glycol) is 5 to 10 nm.

Abstract translation: 提供包含氧化锰纳米颗粒的MRI（磁共振成像）T1对比剂，以增强与常规T1加权图像相比的图像分辨率，通过提高细胞穿透能力和最小化副作用来显示细胞分布。 MRI T1对比剂包括由选自聚乙烯醇，聚丙交酯，聚乙交酯，聚（丙交酯 - 共 - 乙交酯），聚酐，聚酯，聚醚酯，聚己内酯，聚酯酰胺，聚丙烯酸酯，聚氨酯，聚氟乙烯， 聚（乙烯基咪唑），氯磺酸酯聚烯烃，聚环氧乙烷，聚（乙二醇）和葡聚糖，其粒径为50nm以下，优选为40nm以下，更优选为35nm以下。 此外，聚（乙二醇）的厚度为5〜10nm。

公开(公告)号：KR1020090119867A

公开(公告)日：2009-11-20

申请号：KR1020097017941

申请日：2008-01-30

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  안광진 ,  나현빈

IPC: A61K49/08 ,  A61K49/06 ,  A61K49/10 ,  B82Y5/00

CPC classification number: A61K49/08 ,  A61K49/126 ,  A61K49/1854 ,  A61K49/1857 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00 ,  Y10T428/2982

Abstract: PURPOSE: An MRI (magnetic resonance imaging) T1 contrast agent is provided to enable anatomy image with high resolution and show cell distribution. CONSTITUTION: An MRI (magnetic resonance imaging) T1 imaging agent contains manganese oxide nanoparticle. In the T1 contrast agent, the manganese oxide nanoparticle is coated with biocompatible material. The biocompatible material is polyvinyl alcohol, polylactide, polyglycol cholide, polylactide glycolide copolymer, polyanhydride, polyester, polyetherester, poIycaprolactone, polyesteramide, polyacrylate, polyurethanes, polyvinylpluoride, and polyvinyl imidazole.

Abstract translation: 目的：提供MRI（磁共振成像）T1造影剂，以使解剖图像具有高分辨率和显示细胞分布。 构成：MRI（磁共振成像）T1成像剂含有氧化锰纳米粒子。 在T1造影剂中，氧化锰纳米颗粒涂有生物相容性材料。 生物相容性材料是聚乙烯醇，聚丙交酯，聚乙二醇胆碱，聚丙交酯乙交酯共聚物，聚酐，聚酯，聚醚酯，聚己内酯，聚酯酰胺，聚丙烯酸酯，聚氨酯，聚氟乙烯和聚乙烯咪唑。