公开(公告)号：KR1020090119867A

公开(公告)日：2009-11-20

申请号：KR1020097017941

申请日：2008-01-30

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  안광진 ,  나현빈

IPC: A61K49/08 ,  A61K49/06 ,  A61K49/10 ,  B82Y5/00

CPC classification number: A61K49/08 ,  A61K49/126 ,  A61K49/1854 ,  A61K49/1857 ,  A61K49/186 ,  A61K49/1863 ,  B82Y5/00 ,  Y10T428/2982

Abstract: PURPOSE: An MRI (magnetic resonance imaging) T1 contrast agent is provided to enable anatomy image with high resolution and show cell distribution. CONSTITUTION: An MRI (magnetic resonance imaging) T1 imaging agent contains manganese oxide nanoparticle. In the T1 contrast agent, the manganese oxide nanoparticle is coated with biocompatible material. The biocompatible material is polyvinyl alcohol, polylactide, polyglycol cholide, polylactide glycolide copolymer, polyanhydride, polyester, polyetherester, poIycaprolactone, polyesteramide, polyacrylate, polyurethanes, polyvinylpluoride, and polyvinyl imidazole.

Abstract translation: 目的：提供MRI（磁共振成像）T1造影剂，以使解剖图像具有高分辨率和显示细胞分布。 构成：MRI（磁共振成像）T1成像剂含有氧化锰纳米粒子。 在T1造影剂中，氧化锰纳米颗粒涂有生物相容性材料。 生物相容性材料是聚乙烯醇，聚丙交酯，聚乙二醇胆碱，聚丙交酯乙交酯共聚物，聚酐，聚酯，聚醚酯，聚己内酯，聚酯酰胺，聚丙烯酸酯，聚氨酯，聚氟乙烯和聚乙烯咪唑。

公开(公告)号：KR1020090038337A

公开(公告)日：2009-04-20

申请号：KR1020070103783

申请日：2007-10-15

Applicant: 재단법인서울대학교산학협력재단 ,  아주대학교산학협력단

Inventor： 현택환 ,  김상욱 ,  나현빈

IPC: C07F9/53 ,  C07F9/50 ,  B82Y5/00

CPC classification number: C07F9/2408 ,  C07F9/2458

Abstract: A bio-compatible suspension stabilizer for dispersing inorganic nano-particles in an aqueous medium is provided to modify surfaces of the inorganic nano-particles to have hydrophilic properties and easily allow ligand having in vivo activity to be accepted. A bio-compatible suspension stabilizer for dispersing inorganic nano-particles in an aqueous medium is phosphin oxide represented by the formula 1. A method for producing the phosphin oxide comprises the following steps of: dissolving a bio-compatible polymer in an organic solvent to prepare a bio-compatible polymer organic solvent; adding phosphin oxide having a leaving group into the prepared bio-compatible polymer organic solvent to bond the phosphin oxide with the bio-compatible polymer; reacting a compound having a functional group in order to induce the functional group which can be bonded with the functional ligand at a position of the leaving group of the bio-compatible polymer.

Abstract translation: 提供了用于将无机纳米颗粒分散在水性介质中的生物相容性悬浮稳定剂，以将无机纳米颗粒的表面改性为具有亲水性，并容易地允许具有体内活性的配体。 用于将无机纳米颗粒分散在水性介质中的生物相容的悬浮稳定剂是由式1表示的氧化膦。氧化膦的制备方法包括以下步骤：将生物相容性聚合物溶解在有机溶剂中以制备 生物相容性聚合物有机溶剂; 在制备的生物相容性聚合物有机溶剂中加入具有离去基团的氧化膦，将氧化膦与生物相容的聚合物键合; 使具有官能团的化合物反应以诱导可在生物相容性聚合物的离去基团的位置处与官能配体结合的官能团。

公开(公告)号：KR1020080071472A

公开(公告)日：2008-08-04

申请号：KR1020070077029

申请日：2007-07-31

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  나현빈 ,  안광진

IPC: A61K49/08 ,  A61K49/10 ,  A61K49/06 ,  B82Y5/00

Abstract: A method for producing an MRI(magnetic resonance imaging) T1 contrasting agent comprising manganese oxide nanoparticle is provided to obtain enhanced fine image as compared to the conventional T1-weighted image, and diagnose and treat cancers by conjugating a cancer marker with the manganese oxide nanoparticle. A method for producing an MRI T1 contrasting agent comprising manganese oxide nanoparticle comprises the steps of: (i) pyrolyzing Mn-C4-25 carboxylate complex to prepare manganese oxide nanoparticles having diameter of 35 nm or less, dispersed in an organic solvent selected from C6-26 aromatic hydrocarbon, C6-26 ether, C6-25 aliphatic hydrocarbon, C6-26 alcohol, C6-26 thiol and C6-25 amine; and (ii) coating the manganese oxide nanoparticles with a biocompatible material selected from polyvinylalcohol, polylactide, polyglycolide, poly(lactide-co-glycolide), polyanhydride, polyester, polyetherester, polycaprolactone, polyesteramide, polyacrylate, polyurethane, polyvinyl fluoride, poly(vinyl imidazole), chlorosulphonate polyolefin, polyethylene oxide, poly(ethylene glycol) and dextran. Further, a thickness of the poly(ethylene glycol) is 5 to 10 nm.

Abstract translation: 提供了包含氧化锰纳米颗粒的MRI（磁共振成像）T1对比剂的制造方法，以与常规T1加权图像相比获得增强的精细图像，并通过将癌症标记物与氧化锰纳米颗粒结合来诊断和治疗癌症 。 制备包含氧化锰纳米颗粒的MRI T1对比剂的方法包括以下步骤：（i）热解Mn-C4-25羧酸盐络合物以制备直径为35nm或更小的氧化锰纳米颗粒，其分散在选自C6的有机溶剂中 -26芳烃，C6-26醚，C6-25脂族烃，C6-26醇，C6-26硫醇和C6-25胺; 和（ii）用选自聚乙烯醇，聚丙交酯，聚乙交酯，聚（丙交酯 - 共 - 乙交酯），聚酐，聚酯，聚醚酯，聚己内酯，聚酯酰胺，聚丙烯酸酯，聚氨酯，聚氟乙烯，聚（乙烯基） 咪唑），氯磺酸盐聚烯烃，聚环氧乙烷，聚（乙二醇）和葡聚糖。 此外，聚（乙二醇）的厚度为5〜10nm。

公开(公告)号：KR1020080071463A

公开(公告)日：2008-08-04

申请号：KR1020070009707

申请日：2007-01-30

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  이정희 ,  나현빈 ,  안광진

IPC: A61K49/08 ,  A61K49/06 ,  A61K49/10 ,  B82Y5/00

Abstract: An MRI(magnetic resonance imaging) T1 contrasting agent comprising manganese oxide nanoparticles is provided to enhance image resolution as compared to the conventional T1-weighted image, show cell distribution by improving cell-penetrating ability and minimize side effects. An MRI T1 contrasting agent comprises manganese oxide nanoparticles which are coated by a biocompatible material selected from polyvinylalcohol, polylactide, polyglycolide, poly(lactide-co-glycolide), polyanhydride, polyester, polyetherester, polycaprolactone, polyesteramide, polyacrylate, polyurethane, polyvinyl fluoride, poly(vinyl imidazole), chlorosulphonate polyolefin, polyethylene oxide, poly(ethylene glycol) and dextran, and have particle size of 50 nm or less, preferably 40 nm or less, or more preferably 35 nm or less. Further, a thickness of the poly(ethylene glycol) is 5 to 10 nm.

Abstract translation: 提供包含氧化锰纳米颗粒的MRI（磁共振成像）T1对比剂，以增强与常规T1加权图像相比的图像分辨率，通过提高细胞穿透能力和最小化副作用来显示细胞分布。 MRI T1对比剂包括由选自聚乙烯醇，聚丙交酯，聚乙交酯，聚（丙交酯 - 共 - 乙交酯），聚酐，聚酯，聚醚酯，聚己内酯，聚酯酰胺，聚丙烯酸酯，聚氨酯，聚氟乙烯， 聚（乙烯基咪唑），氯磺酸酯聚烯烃，聚环氧乙烷，聚（乙二醇）和葡聚糖，其粒径为50nm以下，优选为40nm以下，更优选为35nm以下。 此外，聚（乙二醇）的厚度为5〜10nm。