公开(公告)号：KR1020080035926A

公开(公告)日：2008-04-24

申请号：KR1020060102604

申请日：2006-10-20

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  김재윤 ,  조명행 ,  김성근 ,  이정희

IPC: A61K49/06 ,  A61K49/12

CPC classification number: A61K49/1887 ,  B82Y5/00

Abstract: A core-shell gold nanoparticle containing magnetic nanoparticles is provided to improve image clearness of MRI(magnetic resonance image) as MRI T2 contrast agent, and efficiency of cancer diagnosis, and rapidly kill the cancer cells by using laser pulse, so that diagnosis and treatment of cancer are performed simultaneously. A core-shell gold nanoparticle contains a silica core having diameter of 50-500 nm and a gold nanoshell having diameter of 50-500 nm with magnetic nanoparticles having diameter of 2-30 nm which contains polyalkylene glycol on the surface of nanoparticles and a target-directing ligand linked to the polyalkylene glycol, wherein the magnetic nanoparticle is selected from magnetite(Fe3O4), maghemite(gamma-Fe3O4), cobalt ferrite(CoFe2O4), manganese oxide(MnO), manganese ferrite(MnFe2O4), ion-platinum alloy, cobalt-platinum alloy and cobalt; the target-directing ligand is selected from anti-HER2/neu, folate, aptamer and TAT peptide.

Abstract translation: 提供含有磁性纳米颗粒的核壳金纳米颗粒，以提高MRI（MRI）造影剂的MRI（磁共振图像）的图像清晰度和癌症诊断的效率，并通过使用激光脉冲快速杀死癌细胞，从而进行诊断和治疗 的癌症同时进行。 核 - 壳金纳米颗粒包含直径为50-500nm的二氧化硅芯和直径为50-500nm的金纳米壳，其直径为2-30nm的磁性纳米颗粒，其在纳米颗粒的表面上含有聚亚烷基二醇和靶 其中磁性纳米颗粒选自磁铁矿（Fe3O4），磁赤铁矿（γ-Fe3O4），钴铁氧体（CoFe2O4），氧化锰（MnO），锰铁氧体（MnFe2O4），离子 - 铂合金 ，钴 - 铂合金和钴; 靶向配体选自抗HER2 / neu，叶酸，适体和TAT肽。

公开(公告)号：KR1020080071463A

公开(公告)日：2008-08-04

申请号：KR1020070009707

申请日：2007-01-30

Applicant: 재단법인서울대학교산학협력재단

Inventor： 현택환 ,  이정희 ,  나현빈 ,  안광진

IPC: A61K49/08 ,  A61K49/06 ,  A61K49/10 ,  B82Y5/00

Abstract: An MRI(magnetic resonance imaging) T1 contrasting agent comprising manganese oxide nanoparticles is provided to enhance image resolution as compared to the conventional T1-weighted image, show cell distribution by improving cell-penetrating ability and minimize side effects. An MRI T1 contrasting agent comprises manganese oxide nanoparticles which are coated by a biocompatible material selected from polyvinylalcohol, polylactide, polyglycolide, poly(lactide-co-glycolide), polyanhydride, polyester, polyetherester, polycaprolactone, polyesteramide, polyacrylate, polyurethane, polyvinyl fluoride, poly(vinyl imidazole), chlorosulphonate polyolefin, polyethylene oxide, poly(ethylene glycol) and dextran, and have particle size of 50 nm or less, preferably 40 nm or less, or more preferably 35 nm or less. Further, a thickness of the poly(ethylene glycol) is 5 to 10 nm.

Abstract translation: 提供包含氧化锰纳米颗粒的MRI（磁共振成像）T1对比剂，以增强与常规T1加权图像相比的图像分辨率，通过提高细胞穿透能力和最小化副作用来显示细胞分布。 MRI T1对比剂包括由选自聚乙烯醇，聚丙交酯，聚乙交酯，聚（丙交酯 - 共 - 乙交酯），聚酐，聚酯，聚醚酯，聚己内酯，聚酯酰胺，聚丙烯酸酯，聚氨酯，聚氟乙烯， 聚（乙烯基咪唑），氯磺酸酯聚烯烃，聚环氧乙烷，聚（乙二醇）和葡聚糖，其粒径为50nm以下，优选为40nm以下，更优选为35nm以下。 此外，聚（乙二醇）的厚度为5〜10nm。