만난이 코팅된 초상자성 산화철 나노입자, 이의 제조방법및 이를 포함하는 간질환 진단용 조영제
    1.
    发明公开
    만난이 코팅된 초상자성 산화철 나노입자, 이의 제조방법및 이를 포함하는 간질환 진단용 조영제 有权
    超级纳米氧化锰纳米粒子,其制备方法和对照药物用于诊断肝病

    公开(公告)号:KR1020090090104A

    公开(公告)日:2009-08-25

    申请号:KR1020080015374

    申请日:2008-02-20

    CPC classification number: A61K49/1863 B82Y5/00 G01N2800/085 H01F1/344

    Abstract: A mannan-coated superparamagnetic iron oxide nanoparticle is provided, which enables specific flow of liver to kupffer cell and ensure stability of ferrofluid. A contrast media for diagnosing hepatism comprises a mannan coated superparamagnetic iron oxide nanoparticle. A method for manufacturing the nanoparticle comprises: a step of adding basic solution in iron chloride aqueous solution and dipping iron oxide nanoparticle; a step of oxidizing the iron oxide nanoparticle and producing storage solution; and a step of mixing mannan solution in the storage solution, stirring and coating.

    Abstract translation: 提供了一种甘露聚糖涂层的超顺磁性氧化铁纳米粒子,其能够使特定的肝脏流向枯否细胞并确保铁磁流体的稳定性。 用于诊断肝脏病的造影剂包括甘露聚糖包被的超顺磁性氧化铁纳米颗粒。 制造纳米颗粒的方法包括:将碱性溶液加入到氯化铁水溶液和浸渍氧化铁纳米颗粒中的步骤; 氧化氧化铁纳米粒子的氧化步骤,制备储存溶液; 以及将甘露聚糖溶液在储存溶液中混合,搅拌和涂布的步骤。

    목적 유전자를 세포로 전달하기 위한 나노 파이버 유전자 전달체
    4.
    发明公开
    목적 유전자를 세포로 전달하기 위한 나노 파이버 유전자 전달체 有权
    用于有效转染到细胞中的NANOFIBER和TARGET DNA的复合组合

    公开(公告)号:KR1020120088215A

    公开(公告)日:2012-08-08

    申请号:KR1020110009413

    申请日:2011-01-31

    CPC classification number: C12N15/87 A61K48/00 B82Y5/00

    Abstract: PURPOSE: A gene delivery system for transferring a target gene to cells is provided to stably transfer the target gene to disease cells or tissues and to reduce toxicity in normal cells. CONSTITUTION: A gene delivery system for transferring a target gene to cells contains: biodegradable polyester amine nanofibers prepared by electrospinning a polymer solution containing polyethyleneimine(PEI) and polycaprolactone(PCL); and a target gene fixed on the nanofiber. The target gene is complexed with branched polyethylenimine cross-linked via disulfide bonds(ssPEI). The target gene is an angiogenic factor gene. A pharmaceutical composition for angiogenesis contains the gene delivery system. The pharmaceutical composition is used for preventing or treating coronary artery disease.

    Abstract translation: 目的:提供将靶基因转移至细胞的基因递送系统,以将目标基因稳定转移至疾病细胞或组织,并降低正常细胞中的毒性。 构成:将靶基因转移至细胞的基因递送系统包含:通过静电纺丝含有聚乙烯亚胺(PEI)和聚己内酯(PCL)的聚合物溶液制备的可生物降解的聚酯胺纳米纤维; 和固定在纳米纤维上的靶基因。 目标基因与通过二硫键交联的支链聚乙烯亚胺(ssPEI)复合。 靶基因是血管生成因子基因。 用于血管生成的药物组合物含有基因递送系统。 该药物组合物用于预防或治疗冠状动脉疾病。

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