公开(公告)号：KR101402058B1

公开(公告)日：2014-06-02

申请号：KR1020120085262

申请日：2012-08-03

Applicant: 조선대학교산학협력단 ,  한국식품연구원

Inventor： 오원근 ,  다오트롱투완 ,  임성일 ,  이성훈 ,  강건욱

IPC: A61K31/122 ,  A61K36/9066 ,  A61P1/16 ,  A61P1/00

Abstract: 본 발명은 청국장 발효 울금 추출물 또는 이로부터 분리된 커큐미노이드 유도체 화합물을 함유하는 간질환의 예방 또는 치료용 조성물에 관한 것이다. 상기 조성물은 간조직 또는 간세포에서의 α-SMA와 TGF-β1의 발현을 억제하고 TNF-α의 양을 감소시키는 효과가 뛰어나 간염, 간섬유증, 간경화증 등의 간질환의 치료제 또는 건강기능식품으로 유용하게 이용될 수 있다.

公开(公告)号：KR1020140018706A

公开(公告)日：2014-02-13

申请号：KR1020120085262

申请日：2012-08-03

Applicant: 조선대학교산학협력단 ,  한국식품연구원

Inventor： 오원근 ,  다오트롱투완 ,  임성일 ,  이성훈 ,  강건욱

IPC: A61K31/122 ,  A61K36/9066 ,  A61P1/16 ,  A61P1/00

Abstract: The present invention relates to a composition for preventing or treating liver diseases containing an extract of fermented curcuma longa using fermented soybeans, or a curcuminoid derivative isolated therefrom. The composition suppresses the expression of α-SMA and TGF-β1 in liver tissues or liver cells, has an excellent effect on reducing the amount of TNF-α, and is capable of being used as a treatment for hepatitis, hepatic fibrosis, and liver cirrhosis, and health functional food. [Reference numerals] (1) Curcumalogin A; (2) Curcumalogin B; (3) Curcumalogin C; (4) Curcumalogin D; (5) 1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; (6) 5-hydroxy-1,7-bis(4-hydroxyphenyl)-4,6-heptadiene-3-one; (7) 1,7-bis(3,4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; (8) 1-(4-hydroxyphenyl)-7-(3,4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; (A) Curcumine; (AA) Control group; (B) Demethoxy curcumin; (BB) Compound process concentration(10μg/ml); (C) Bis-demethoxy curcumin

Abstract translation: 本发明涉及一种用于预防或治疗含有发酵姜黄提取物的发酵大豆或由其分离的姜黄素衍生物的肝病的组合物。 该组合物抑制肝组织或肝细胞中α-SMA和TGF-β1的表达，对减少TNF-α的量具有优异的作用，并且能够用作肝炎，肝纤维化和肝脏的治疗 肝硬化和健康功能食品。 [参考编号]（1）姜黄素A; （2）姜黄素B; （3）Curcumalogin C; （4）Curcumalogin D; （5）1-（4-羟基-3-甲氧基苯基）-7-（3,4-羟基苯基）-1,6-庚二烯-3,5-二酮; （6）5-羟基-1,7-双（4-羟基苯基）-4,6-庚二烯-3-酮; （7）1,7-双（3,4-羟苯基）-1,6-庚二烯-3,5-二酮; （8）1-（4-羟基苯基）-7-（3,4-羟基苯基）-1,6-庚二烯-3,5-二酮; （A）姜黄素; （AA）对照组; （B）去甲氧基姜黄素; （BB）复方过程浓度（10μg/ ml）; （C）双脱甲氧基姜黄素

公开(公告)号：KR101334143B1

公开(公告)日：2013-11-28

申请号：KR1020120062490

申请日：2012-06-12

Applicant: 조선대학교산학협력단 ,  주식회사 중앙백신연구소

Inventor： 오원근 ,  다오트롱투완 ,  누엔버치트 ,  최환원 ,  원호근 ,  윤인중

IPC: A61K31/352 ,  A61K31/35 ,  A61P31/16 ,  A61P31/12

Abstract: The present invention relates to a composition containing a Polygala karensium extract and xanthone-based compounds isolated from the same for preventing or treating flu, avian influenza, swine influenza, or novel swine-origin influenza. The Polygala karensium extract and xanthone-based compounds isolated from the same effectively and non-selectively suppress neuraminidase of flu virus, avian influenza virus, swine influenza virus, novel swine-origin influenza, and Tamiflu resistant novel swine-origin influenza virus, thereby being used as a therapeutic agent for treating flu, avian influenza, swine influenza, and swine-origin influenza and being applied in cosmetic products, health foods, animal feeds, and an animal medicinal industry. [Reference numerals] (AA) Swine influenza virus (H1N1);(BB,HH,NN,TT) Compound 1;(CC,II,OO,UU) Compound 2;(DD,JJ,PP,VV) Compound 3;(EE,KK,QQ,WW) Compound 4;(FF,LL,RR,XX) Compound 5;(GG) Avian influenza virus (H9N2);(MM) Novel swine-origin influenza virus (novel H1N1);(SS) Novel swine-origin influenza virus resistant to Tamiflu (H1N1[H274Y])

Abstract translation: 本发明涉及含有从其分离的Polygala karensium提取物和基于呫吨酮的化合物预防或治疗流感，禽流感，猪流感或新型猪源性流感的组合物。 从同样有效和非选择性地抑制流感病毒，禽流感病毒，猪流感病毒，新型猪源性流感病毒和Tamiflu抗性新型猪源性流感病毒的神经氨酸酶分离的Polygala karensium提取物和基于呫吨酮的化合物，从而被 用作治疗流感，禽流感，猪流感和猪源性流感的治疗剂，并用于化妆品，保健食品，动物饲料和动物医药行业。 化合物1;（CC，II，OO，UU）化合物2;（DD，JJ，PP，VV）化合物3;（AA）猪流感病毒（H1N1）;（BB，HH，NN，TT） （EE，KK，QQ，WW）化合物4;（FF，LL，RR，XX）化合物5;（GG）禽流感病毒（H9N2）;（MM）新型猪源性流感病毒（新型H1N1） ）抗Tamiflu（H1N1 [H274Y]）新型猪源性流感病毒

公开(公告)号：KR100950445B1

公开(公告)日：2010-04-02

申请号：KR1020090101628

申请日：2009-10-26

Applicant: 주식회사 중앙백신연구소 ,  조선대학교산학협력단

Inventor： 윤인중 ,  이홍식 ,  김동원 ,  오원근 ,  박준수 ,  부이탄텅 ,  다오트롱투완

IPC: A61K36/484 ,  A61P31/16 ,  A23L1/30 ,  A61K31/12

CPC classification number: A61K31/12 ,  A23K20/111 ,  A23L2/52 ,  A23L29/035 ,  A61K36/484 ,  A61K2236/333 ,  Y10S514/888

Abstract: PURPOSE: A Glycyrrhiza uralensis extract and calcone based compounds suppressing neuraminidase are provided to treat novel swine-origin influenza. CONSTITUTION: A Glycyrrhiza uralensis extract for preventing or treating avian and swine ingluenza contains is extracted using ethanol or methanol and contains chalcone based compound. The chalcone based compound is Licochacone F, Echicnatin, Licochalcon D, Licochalcone A, Isoliquiritigenin, Licoagrochalcone A, 5-Prenylbutein and Kanzonol C. A functional health food for preventing or treating diseases relating to avian and swine influenza contains Glycyrrhiza uralensis extract. A pharmaceutical composition for preventing or treating diseases relating to avian and swine influenza contains Glycyrrhiza uralensis extract or chalcone compouns as active ingredient. The pharmaceutical composition also contains pharmaceutically acceptable carrier or excipient.

Abstract translation: 目的：提供甘草提取物和基于煅烧物的抑制神经氨酸酶的化合物，用于治疗新型猪源性流感。 构成：用乙醇或甲醇提取用于预防或治疗禽流感和猪流感病毒的甘草提取物，并含有查耳酮基化合物。 基于查耳酮的化合物是Licochacone F，Echicnatin，Licochalcon D，Licochalcone A，Isoliquiritigenin，Licoagrochalcone A，5-丙氨酸丁醇和Kanzonol C.用于预防或治疗与禽流感和猪流感有关的疾病的功能保健食品含有甘草提取物。 用于预防或治疗与禽流感和猪流感有关的疾病的药物组合物含有甘草提取物或查耳酮组合物作为活性成分。 药物组合物还含有药学上可接受的载体或赋形剂。