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公开(公告)号：KR1020120120545A
公开(公告)日：2012-11-02
申请号：KR1020110038157
申请日：2011-04-25
Applicant: 충남대학교산학협력단
IPC: A61K31/12 , A61K31/045 , A61P19/10 , A61P19/00
Abstract: PURPOSE: A composition containing xanthohumol is provided to promote differentiation of osteoclast and to treat bone diseases. CONSTITUTION: A composition for preventing or treating osteoclast differentiation contains xanthohumol as an active ingredient. The composition contains xanthohumol and bone resorption inhibitor as an active ingredient. The bone absorption inhibitor is bisphosphonate, estrogen, calcitonin, vitamin D, calcium, fluoride, anabolic steroid or parathyroid hormone. A health functional food for preventing or treating osteoporosis contains xanthohumol as an active ingredient. The health functional food includes drink, meat, sausage, bread, candy, snack, noodle, ice cream, soup, isotonic drink, alcohol beverage, or vitamin complex.
Abstract translation: 目的：提供含有黄腐酚的组合物，以促进破骨细胞的分化和治疗骨骼疾病。 构成：用于预防或治疗破骨细胞分化的组合物含有黄单胞菌素作为活性成分。 该组合物含有黄单胞菌素和骨吸收抑制剂作为活性成分。 骨吸收抑制剂是二膦酸盐，雌激素，降钙素，维生素D，钙，氟化物，合成代谢类固醇或甲状旁腺激素。 用于预防或治疗骨质疏松症的保健功能食品含有黄腐酚醇作为活性成分。 健康功能食品包括饮料，肉类，香肠，面包，糖果，小吃，面条，冰淇淋，汤，等渗饮料，酒精饮料或维生素复合物。
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公开(公告)号：KR1020120024159A
公开(公告)日：2012-03-14
申请号：KR1020100086886
申请日：2010-09-06
Applicant: 충남대학교산학협력단
Abstract: PURPOSE: A composition containing purple sweet potato extract is provided to suppress fibrosis of rat liver cells and to prevent and treat fibrosis. CONSTITUTION: A pharmaceutical composition for preventing or treating hepatic fibrosis contains extract as an active ingredient, prepared by extracting purple sweet potato using 50-100% ethanol solution. A health food for preventing or treating hepatic fibrosis contains the ethanol solution as an active ingredient. The health food is manufactured in the form of a daily product including drink, meats, sausage, candy, bread, noodle, and ice cream.
Abstract translation: 目的：提供含有紫甘薯提取物的组合物以抑制大鼠肝细胞的纤维化并预防和治疗纤维化。 构成：用于预防或治疗肝纤维化的药物组合物含有提取物作为活性成分，通过使用50-100％乙醇溶液提取紫色甘薯制备。 用于预防或治疗肝纤维化的保健食品含有乙醇溶液作为活性成分。 保健食品以日常产品的形式制造，包括饮料，肉类，香肠，糖果，面包，面条和冰淇淋。
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公开(公告)号：KR101323150B1
公开(公告)日：2013-10-30
申请号：KR1020110038157
申请日：2011-04-25
Applicant: 충남대학교산학협력단
IPC: A61K31/12 , A61K31/045 , A61P19/10 , A61P19/00
Abstract: 본 발명은 잔토휴몰을 유효성분으로 하는 골다공증 예방 및 치료용 조성물에 관한 것으로 상기 잔토휴몰은 조골세포의 분화를 촉진하는 효과가 있어 골다공증을 비롯한 골질환의 치료에 효과적이다.
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公开(公告)号：KR1020120045804A
公开(公告)日：2012-05-09
申请号：KR1020100107610
申请日：2010-11-01
Applicant: 충남대학교산학협력단
IPC: A61K31/19 , A61K31/185 , A61K36/185 , A61P35/00
Abstract: PURPOSE: A pharmaceutical composition containing 3-caffeoyl-4-dihydrocaffeoyl quinic acid(CDCQ) is provided to suppress cell basal lamina digesting enzyme MMP-2 and MMP-9 activities and prevent cancer cell metastasis. CONSTITUTION: A pharmaceutical composition for suppressing cancer metastasis contains 3-caffeoyl-4-dihydrocaffeoylquinic acid. The composition suppresses activity of MMP-2(matrix metalloprotease-2) or MMP-9(matrix metalloprotease-9). A health food for preventing metastasis contains 3-caffeoyl-4-dihydrocaffeoylquinic acid. A composition for anticancer and metastasis suppression contains 3-caffeoyl-4-dihydrocaffeoylquinic acid and anticancer agent as an active ingredient. The anticancer agent includes busulfan, chlorambucil, cyclophosphamide, melphalan, nitrogen mustard, BCNU(1,3-bis (2-chloroethyl)-1 nitrosourea), CCNU(l-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosourea), MeCCNU(1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea), cisplatin, ifosfamide, cytarabine, fluouracil(5-FU), mercaptopurine(6-MP), methotrexate(MTX), actinomycin-D, bleomycin, daunorubicin, adriamycin, mitomycin-C, vinblastine, vincristine(oncovin), vindesine, VP-16(etoposide), L-aspraginase, dacarbazine(DTIC) or hydroxyurea.
Abstract translation: 目的：提供含有3-咖啡酰基-4-二氢樟脑酸奎胺酸（CDCQ）的药物组合物，以抑制细胞基底层消化酶MMP-2和MMP-9活性，并预防癌细胞转移。 构成：用于抑制癌症转移的药物组合物含有3-咖啡酰基-4-二氢樟脑酰奎宁酸。 该组合物抑制MMP-2（基质金属蛋白酶-2）或MMP-9（基质金属蛋白酶-9）的活性。 用于预防转移的保健食品含有3-咖啡酰基-4-二氢樟脑酸奎宁酸。 用于抗癌和转移抑制的组合物含有3-咖啡酰基-4-二氢樟脑酸奎宁酸和抗癌剂作为活性成分。 抗癌剂包括白消安，苯丁酸氮芥，环磷酰胺，美法仑，氮芥，BCNU（1,3-二（2-氯乙基）-1亚硝基脲），CCNU（1-（2-氯乙基）-3-环己基-1-硝基脲） ，MeCCNU（1-（2-氯乙基）-3-（4-甲基 - 环己基）-1-亚硝基脲），顺铂，异环磷酰胺，阿糖胞苷，氟尿嘧啶（5-FU），巯嘌呤（6-MP），甲氨蝶呤 ，放线菌素D，博来霉素，柔红霉素，阿霉素，丝裂霉素C，长春花碱，长春新碱（翁科），长春地辛，VP-16（依托泊苷），L-天冬酰胺酶，达卡巴嗪（DTIC）或羟基脲。
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5.发明公开
公开(公告)号：KR1020140112147A
公开(公告)日：2014-09-23
申请号：KR1020130026058
申请日：2013-03-12
Applicant: 충남대학교산학협력단
IPC: A61K31/05 , A61K31/19 , A61K31/185 , A61P3/04
Abstract: The present invention relates to a composition comprising 3-caffeoyl-4-dihydrocaffeoylquinic acid for preventing or treating fatty liver or obesity. The 3-caffeoyl-4-dihydrocaffeoylquinic acid has an excellent effect of inhibiting the synthesis of fatty acids, cholesterol, and triglycerides in a fatty liver cell model, increases the activity of AMPK which is associated with lipogenesis suppression, and has an excellent effect of inhibiting activities of SREBP-1 and FAS which are transcription factors of fatty acid synthesis, thus can be usefully applied as a therapeutic agent for fatty liver or obesity.
Abstract translation: 本发明涉及包含用于预防或治疗脂肪肝或肥胖症的3-咖啡酰基-4-二氢樟脑醌奎酸的组合物。 3-咖啡酰-4-二氢樟脑醌酸在脂肪肝细胞模型中具有抑制脂肪酸，胆固醇和甘油三酸酯合成的优异效果，增加了与脂肪生成抑制相关的AMPK的活性，并且具有优异的 抑制作为脂肪酸合成转录因子的SREBP-1和FAS的活性，因此可以有效地用作脂肪肝或肥胖的治疗剂。
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Patent Agency Ranking
公开(公告)号：KR101323157B1
公开(公告)日：2013-10-30
申请号：KR1020100107610
申请日：2010-11-01
Applicant: 충남대학교산학협력단
IPC: A61K31/19 , A61K31/185 , A61K36/185 , A61P35/00
Abstract: 본 발명은 함초 유래의 3-카페오일-4-다이하이드로카페오일 퀴닉산(3-caffeoyl-4-dihydrocaffeoylquinic acid, CDCQ)을 함유하는 암 전이 억제용 약학 조성물에 관한 것으로, 본 발명의 함초 유래의 3-카페오일-4-다이하이드로카페오일 퀴닉산(3-caffeoyl-4-dihydrocaffeoylquinic acid, CDCQ)을 함유하는 조성물은 세포침투에 관여하는 세포 기저막 용해효소 MMP(matrix metalloprotease)-2 및 MMP-9(matrix metalloprotease-9)의 활성을 저해하고 암세포 전이를 억제시키는 효과가 뛰어나 암세포에 대한 전이를 억제시키는 의약품이나 암 전이 예방용 건강기능식품으로 유용하게 사용될 수 있다.
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7.发明授权
公开(公告)号：KR101448466B1
公开(公告)日：2014-10-16
申请号：KR1020130026058
申请日：2013-03-12
Applicant: 충남대학교산학협력단
IPC: A61K31/05 , A61K31/19 , A61K31/185 , A61P3/04
Abstract: 본 발명은 3-카페오일-4-다이하이드로카페오일 퀴닉산을 함유하는 지방간 또는 비만의 예방 또는 치료용 조성물에 관한 것으로서, 상기 3-카페오일-4-다이하이드로카페오일 퀴닉산은 지방간 모델 세포에서 지방산, 콜레스테롤 및 트리글리세리드의 합성을 억제하는 효과가 우수하고, 지방 생성 억제와 관련이 있는 AMPK의 활성을 높이며, 지방산 합성의 전사인자인 SREBP-1 및 FAS의 활성을 억제하는 효과가 뛰어나기에, 지방간 또는 비만의 치료제로서 용이하게 이용될 수 있다.
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公开(公告)号：KR101325094B1
公开(公告)日：2013-11-06
申请号：KR1020110019281
申请日：2011-03-04
Applicant: 충남대학교산학협력단 , (주)머쉬토피아
Abstract: 본 발명은 아토피 피부염의 예방 또는 치료용 조성물에 관한 것으로서, 더욱 상세하게는 아토피 피부염과 같은 각종 피부질환의 증세를 치료 또는 경감시키는 활성이 탁월한 새송이버섯 추출물에 관한 것이다.
본 발명에서는 상기 새송이버섯 추출물이 아토피 피부염에서 증가된다고 알려진 사이토카인 및 단백질인 TARC/CCL17, MDC/CCL22, CTACK/CCL27, ICAM-1 등의 발현을 감소시키는 것을 나타냄으로, 상기 추출물이 아토피 피부염의 치료제로 사용될 수 있음을 확인할 수 있다.-
公开(公告)号：KR1020120100414A
公开(公告)日：2012-09-12
申请号：KR1020110019281
申请日：2011-03-04
Applicant: 충남대학교산학협력단 , (주)머쉬토피아
Abstract: PURPOSE: A composition for preventing or treating atopic dermatitis which contains pine mushroom extracts is provided to reduce expression of cytokine and TARC/CCL17, MDC/CCL22, CTACK/CCL27,and ICAM-1 which are proteins. CONSTITUTION: A composition for preventing or treating atopic dermatitis contains pine mushroom extracts as active ingredient. The organic solvent is ethanol. A health supplement for preventing or treating atopic dermatitis includes the extract of the organic solvent of the pine mushroom as the active ingredient. The pine mushroom extracts is obtained by the following steps: extracting the pine mushroom by using the polar solvent like ethanol water soluble solution, propanol, butanol, isopropanol, ethyl acetate, ether, acetone, chloroform and a mixed solvent thereof; easily obtaining by using a single or combining an adsorbent method like a Diaion HP-20 resin, dispersion of hexane and water, and a method using for separation extracting of plant components like column chromatography.
Abstract translation: 目的：提供一种用于预防或治疗特应性皮炎的组合物，其含有松果提取物，以减少作为蛋白质的细胞因子和TARC / CCL17，MDC / CCL22，CTACK / CCL27和ICAM-1的表达。 构成：用于预防或治疗特应性皮炎的组合物含有松果提取物作为活性成分。 有机溶剂为乙醇。 用于预防或治疗特应性皮炎的健康补充剂包括作为活性成分的松蘑的有机溶剂的提取物。 通过以下步骤获得松蘑菇提取物：使用极性溶剂如乙醇水溶液，丙醇，丁醇，异丙醇，乙酸乙酯，乙醚，丙酮，氯仿及其混合溶剂萃取松菇; 通过使用单一的或组合吸附剂方法如Diaion HP-20树脂，己烷和水的分散体以及用于分离提取植物组分如柱色谱法的方法容易地获得。
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