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公开(公告)号：KR101325094B1
公开(公告)日：2013-11-06
申请号：KR1020110019281
申请日：2011-03-04
Applicant: 충남대학교산학협력단 , (주)머쉬토피아
Abstract: 본 발명은 아토피 피부염의 예방 또는 치료용 조성물에 관한 것으로서, 더욱 상세하게는 아토피 피부염과 같은 각종 피부질환의 증세를 치료 또는 경감시키는 활성이 탁월한 새송이버섯 추출물에 관한 것이다.
본 발명에서는 상기 새송이버섯 추출물이 아토피 피부염에서 증가된다고 알려진 사이토카인 및 단백질인 TARC/CCL17, MDC/CCL22, CTACK/CCL27, ICAM-1 등의 발현을 감소시키는 것을 나타냄으로, 상기 추출물이 아토피 피부염의 치료제로 사용될 수 있음을 확인할 수 있다.-
公开(公告)号：KR1020120100414A
公开(公告)日：2012-09-12
申请号：KR1020110019281
申请日：2011-03-04
Applicant: 충남대학교산학협력단 , (주)머쉬토피아
Abstract: PURPOSE: A composition for preventing or treating atopic dermatitis which contains pine mushroom extracts is provided to reduce expression of cytokine and TARC/CCL17, MDC/CCL22, CTACK/CCL27,and ICAM-1 which are proteins. CONSTITUTION: A composition for preventing or treating atopic dermatitis contains pine mushroom extracts as active ingredient. The organic solvent is ethanol. A health supplement for preventing or treating atopic dermatitis includes the extract of the organic solvent of the pine mushroom as the active ingredient. The pine mushroom extracts is obtained by the following steps: extracting the pine mushroom by using the polar solvent like ethanol water soluble solution, propanol, butanol, isopropanol, ethyl acetate, ether, acetone, chloroform and a mixed solvent thereof; easily obtaining by using a single or combining an adsorbent method like a Diaion HP-20 resin, dispersion of hexane and water, and a method using for separation extracting of plant components like column chromatography.
Abstract translation: 目的：提供一种用于预防或治疗特应性皮炎的组合物，其含有松果提取物，以减少作为蛋白质的细胞因子和TARC / CCL17，MDC / CCL22，CTACK / CCL27和ICAM-1的表达。 构成：用于预防或治疗特应性皮炎的组合物含有松果提取物作为活性成分。 有机溶剂为乙醇。 用于预防或治疗特应性皮炎的健康补充剂包括作为活性成分的松蘑的有机溶剂的提取物。 通过以下步骤获得松蘑菇提取物：使用极性溶剂如乙醇水溶液，丙醇，丁醇，异丙醇，乙酸乙酯，乙醚，丙酮，氯仿及其混合溶剂萃取松菇; 通过使用单一的或组合吸附剂方法如Diaion HP-20树脂，己烷和水的分散体以及用于分离提取植物组分如柱色谱法的方法容易地获得。
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公开(公告)号：KR1020120121646A
公开(公告)日：2012-11-06
申请号：KR1020110039568
申请日：2011-04-27
Applicant: (주)머쉬토피아
CPC classification number: A61K8/97 , A61K8/922 , A61K36/05 , A61K36/07 , A61K36/232 , A61K36/78 , A61K36/886 , A61K2236/33 , A61Q19/10 , Y10S514/844
Abstract: PURPOSE: A skin cleansing composition such as soap or cleansing oil is provided to increase income of Pleurotus eryngii farmhouses. CONSTITUTION: A skin cleansing composition for improving skin condition using Pleurotus eryngii contains: an organic solvent extract of Pleurotus eryngii; Pleurotus eryngii powder or Pleurotus eryngii-infused oil; vegetable base oil; essential oil; vitamin E; and caustic soda or solubilizing agent. A method for manufacturing natural soap for improving skin condition using Pleurotus eryngii comprises: a step of mixing Pleurotus eryngii ethanol extract and purified water to prepare base water; a step of mixing the base water with caustic soda and cooling to prepare caustic soda water; a step of heating the vegetable base oil at 35-40 Deg. C.; a step of mixing the caustic soda water and base oil; a step of adding Pleurotus eryngii power and vitamin E; a step of adding essential oil and Pleurotus eryngii ethanol extract; a step of pouring the mixture into a soap frame and molding; a step of warming the mold at 50-70 Deg. C. for 18-36 hours; and a step of storing the soap at 15-30 Deg. C. for 20-80 days.
Abstract translation: 目的：提供一种皮肤清洁组合物，如肥皂或清洁油，以增加白头翁养殖场的收入。 构成：使用侧耳菇改善皮肤状况的皮肤清洁组合物含有：侧耳菇的有机溶剂提取物; 侧耳菇或侧耳红细胞浸润油; 蔬菜基础油; 香精油; 维生素E; 和苛性钠或增溶剂。 使用侧耳菇制备天然皂改善皮肤状况的方法包括：将侧耳菇提取物与纯化水混合以制备基础水的步骤; 将碱水与苛性钠混合并冷却以制备苛性钠水的步骤; 在35-40度加热蔬菜基础油的步骤。 C。; 将苛性苏打水和基础油混合的步骤; 增加侧耳红细胞功能和维生素E的一个步骤; 加入精油和侧耳菇提取物的步骤; 将混合物倒入肥皂架并成型的步骤; 在50-70度加热模具的步骤。 C. 18-36小时; 以及将肥皂储存在15-30度的步骤。 C. 20-80天。
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公开(公告)号：KR101864121B1
公开(公告)日：2018-06-04
申请号：KR1020150141361
申请日：2015-10-08
Applicant: 충남대학교산학협력단
IPC: A61K36/254 , A23L1/30
Abstract: 본발명은섬오갈피잎 추출물을함유하는혈관질환의예방또는치료용조성물에관한것으로서, 상기섬오갈피잎 추출물은혈관내피세포의 eNOS (endothelial nitric oxide synthase)를활성화시키는효과가우수하여, 동맥경화증, 말초혈관폐쇄증, 혈관재협착증, 고혈압, 협심증, 심근경색, 허혈성심장질환, 뇌졸중, 뇌경색, 뇌출혈등과같은각종혈관질환의치료용조성물로용이하게이용될수 있다.
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公开(公告)号：KR1020150083698A
公开(公告)日：2015-07-20
申请号：KR1020140003553
申请日：2014-01-10
Applicant: 충남대학교산학협력단 , 잎새마을(주)농업회사법인
IPC: A61K31/704 , A61K31/702 , A61K31/70 , A61P9/00
CPC classification number: A61K31/704 , A61K31/70 , A61K31/702
Abstract: 본발명은장생도라지추출물또는이로부터분리된사포닌화합물을함유하는혈관노화억제용조성물에관한것으로서, 상기조성물은시르투인 1(sirtuin 1)의활성을증가시키고, 혈관내피세포의노화를억제하는효과가우수하여, 혈관노화억제용조성물또는혈관노화예방용건강기능식품으로용이하게사용될수 있다.
Abstract translation: 本发明涉及从其分离出的用于抑制血管老化的桔梗提取物或皂苷化合物。 具有抑制血管内皮细胞老化的优异效果的组合物可以增加sirtuin 1的活化，因此可有效地用作抑制血管衰老的组合物或用于预防血管老化的健康功能食品。
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Patent Agency Ranking
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7.发明公开
公开(公告)号：KR1020140112147A
公开(公告)日：2014-09-23
申请号：KR1020130026058
申请日：2013-03-12
Applicant: 충남대학교산학협력단
IPC: A61K31/05 , A61K31/19 , A61K31/185 , A61P3/04
Abstract: The present invention relates to a composition comprising 3-caffeoyl-4-dihydrocaffeoylquinic acid for preventing or treating fatty liver or obesity. The 3-caffeoyl-4-dihydrocaffeoylquinic acid has an excellent effect of inhibiting the synthesis of fatty acids, cholesterol, and triglycerides in a fatty liver cell model, increases the activity of AMPK which is associated with lipogenesis suppression, and has an excellent effect of inhibiting activities of SREBP-1 and FAS which are transcription factors of fatty acid synthesis, thus can be usefully applied as a therapeutic agent for fatty liver or obesity.
Abstract translation: 本发明涉及包含用于预防或治疗脂肪肝或肥胖症的3-咖啡酰基-4-二氢樟脑醌奎酸的组合物。 3-咖啡酰-4-二氢樟脑醌酸在脂肪肝细胞模型中具有抑制脂肪酸，胆固醇和甘油三酸酯合成的优异效果，增加了与脂肪生成抑制相关的AMPK的活性，并且具有优异的 抑制作为脂肪酸合成转录因子的SREBP-1和FAS的活性，因此可以有效地用作脂肪肝或肥胖的治疗剂。
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公开(公告)号：KR101323157B1
公开(公告)日：2013-10-30
申请号：KR1020100107610
申请日：2010-11-01
Applicant: 충남대학교산학협력단
IPC: A61K31/19 , A61K31/185 , A61K36/185 , A61P35/00
Abstract: 본 발명은 함초 유래의 3-카페오일-4-다이하이드로카페오일 퀴닉산(3-caffeoyl-4-dihydrocaffeoylquinic acid, CDCQ)을 함유하는 암 전이 억제용 약학 조성물에 관한 것으로, 본 발명의 함초 유래의 3-카페오일-4-다이하이드로카페오일 퀴닉산(3-caffeoyl-4-dihydrocaffeoylquinic acid, CDCQ)을 함유하는 조성물은 세포침투에 관여하는 세포 기저막 용해효소 MMP(matrix metalloprotease)-2 및 MMP-9(matrix metalloprotease-9)의 활성을 저해하고 암세포 전이를 억제시키는 효과가 뛰어나 암세포에 대한 전이를 억제시키는 의약품이나 암 전이 예방용 건강기능식품으로 유용하게 사용될 수 있다.
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公开(公告)号：KR101322664B1
公开(公告)日：2013-10-30
申请号：KR1020130036604
申请日：2013-04-04
Applicant: 충남대학교산학협력단
IPC: A61K31/352 , A61K31/35 , A61P35/00
Abstract: PURPOSE: An anticancer composition comprising mollugin is provided to use as a therapeutic agent for cancer patients who have tolerance to existing anticancer drugs by having an excellent effect of killing multidrug resistance cancer cells. CONSTITUTION: An anticancer composition having an effect of killing multidrug resistance cancel cells comprises mollugin of chemical formula 1. The multidrug resistance cancer cells are cancer cells which express multidrug resistance 1 (MDR1). The composition increases activation of AMP-activated protein kinase (AMPK). An anticancer drung is added to the composition. The mollugin is comprised in the composition in a ratio of 0.001-99 wt%.
Abstract translation: 目的：提供包含蜕皮素的抗癌组合物，作为对现有抗癌药物具有耐受性的癌症患者的治疗剂，具有杀死多药耐药性癌细胞的优异效果。 构成：具有杀伤多药耐药性细胞杀伤作用的抗癌组合物包括化学式1的蜕皮。多药耐药性癌细胞是表达多药耐药性1（MDR1）的癌细胞。 组合物增加AMP活化蛋白激酶（AMPK）的活化。 向组合物中加入抗癌剂。 该组合物以0.001-99重量％的比例包含该组合物。
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