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公开(公告)号：WO2019009495A1
公开(公告)日：2019-01-10
申请号：PCT/KR2018/002616
申请日：2018-03-06
Applicant: 한국과학기술연구원
IPC: C09K11/02 , C09K11/77 , G01N33/58 , G01N33/543 , G01N21/35 , G01N33/558
Abstract: 본 발명은 입자의 크기를 유지하면서도 발광 강도가 강화된 적외선을 흡광하여 적외선을 발광하는 나노입자를 이용하여 고감도로 타겟물질을 신속하게 진단할 수 있는 진단키트에 대한 것이다.
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公开(公告)号：KR101231157B1
公开(公告)日：2013-02-08
申请号：KR1020110067573
申请日：2011-07-07
Applicant: 한국과학기술연구원
Abstract: 본 발명은 종이에 묻은 혈액 시료로부터 혈액 내 생체화합물을 직접 분석할 수 있는 방법에 관한 것이다.
본 발명은 별도의 시료 전처리 과정 없이 종이에 묻은 혈액 시료로부터 생체화합물을 직접 분석할 수 있으므로, 안전성 및 시료채취의 단점을 극복하고, 신속하면서도 재현성 있는 분석을 수행할 수 있다.-
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公开(公告)号：KR101953313B1
公开(公告)日：2019-03-04
申请号：KR1020170094241
申请日：2017-07-25
Applicant: 한국과학기술연구원
IPC: C07C311/44 , C07C303/36 , G01N21/64 , G01N33/74
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公开(公告)号：KR101260453B1
公开(公告)日：2013-05-06
申请号：KR1020110095963
申请日：2011-09-22
Applicant: 한국과학기술연구원
Abstract: 본발명은생체시료내 스테로이드호르몬들의수산화대사에관여하는여러종류의시토크롬 P450 효소들의활성을질량분석기를이용하여동시에측정및 비교할수 있는분석방법에관한것이다. 본발명은소변과같은생체시료로부터약물복용에따른스테로이드호르몬대사와관련이있는여러종류의시토크롬 P450 효소들의활성도변화를그 대사산물들간의농도비율로나타냄으로써한 번의전처리와분석으로동시에측정할수 있다. 따라서특정약물복용에따른시토크롬 P450 효소활성도변화를통한약물효능평가및 대사기전을총체적으로평가할수 있고, 약물유전체기반의시토크롬 P450 효소분석과의교차검증(cross-validation)이가능한분석기술로도활용할수 있다. 또한, 이들의축척된정보들은신약개발및 약물대사뿐만아니라시토크롬 P450 효소들의활성과관련되는질환등의연구에있어서광범위하게적용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020130032198A
公开(公告)日：2013-04-01
申请号：KR1020110095963
申请日：2011-09-22
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A simultaneous assay method of multiplex cytochrome P450 enzyme activity is provided to simultaneously measure the activity change of various cytochrome P450 enzymes and to study diseases related to the cytochrome P450 enzyme activity. CONSTITUTION: A simultaneous assay method of multiplex cytochrome P450 enzyme activity comprises: a step of simultaneously extracting steroid hormone metabolic products including male hormones, female hormones, corpus luteum hormones, sterol, and adrenal cortical hormones from urine; a step of re-extracting the extracts using an organic solvent and performing trimethyl silyl derivatization; and a step of measuring the concentration of steroid hormone biometabolic products in the urine by gas chromatography-mass spectrometer. [Reference numerals] (AA) Before dosing a drug; (BB) After dosing a drug;
Abstract translation: 目的：提供多重细胞色素P450酶活性的同时测定方法，以同时测量各种细胞色素P450酶的活性变化，并研究与细胞色素P450酶活性相关的疾病。 构成：多重细胞色素P450酶活性的同时测定方法包括：从尿中同时提取包括雄性激素，雌激素，黄体激素，固醇和肾上腺皮质激素的类固醇激素代谢产物的步骤; 使用有机溶剂重新萃取提取物并进行三甲基甲硅烷基衍生化的步骤; 以及通过气相色谱 - 质谱仪测量尿中类固醇激素生物代谢产物浓度的步骤。 （AA）给药前给药; （BB）给药药物后;
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公开(公告)号：KR101200423B1
公开(公告)日：2012-11-12
申请号：KR1020110047673
申请日：2011-05-20
Applicant: 한국과학기술연구원
IPC: G01N30/72 , G01N30/02 , G01N33/74 , G01N33/487
Abstract: PURPOSE: A high sensitive analyzing method of estrogen metabolites in urine and blood obtained from postmenopausal women is provided to verify the overall distribution of estrogen metabolism and to be used for overcoming diseases related to estrogen metabolism. CONSTITUTION: A high sensitive analyzing method of estrogen metabolites in urine and blood obtained from postmenopausal women includes the following steps: estrogen is simultaneously extracted from urine and blood obtained from postmenopausal women and is hydrolyzed; the hydrolyzed product is alkoxy carbonylated using C1-4 alkyl chloroformate, and the resultant product is re-extracted using an organic solvent to obtain a re-extract; and the re-extract is acyl-derivated, and the concentration of estrogen is measured in the acyl-derivated product using a gas chromatography-mass spectrometry. The organic solvent is one or the mixture of normal hexane, normal pentane, butyl methyl ether, and ethyl acetate.
Abstract translation: 目的：提供从绝经后妇女获得的尿液和血液中雌激素代谢物的高灵敏度分析方法，以验证雌激素代谢的总体分布，并用于克服与雌激素代谢相关的疾病。 构成：从绝经后妇女获得的尿液和血液中雌激素代谢物的高灵敏度分析方法包括以下步骤：从绝经后妇女获得的尿液和血液中同时提取雌激素，并进行水解; 水解产物是使用氯甲酸C 1-4烷基羰基化烷氧基，所得产物用有机溶剂再萃取，得到再提取物; 并且再提取物是酰基衍生的，并且使用气相色谱 - 质谱法在酰基衍生的产物中测量雌激素的浓度。 有机溶剂是一种或正己烷，正戊烷，丁基甲基醚和乙酸乙酯的混合物。
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公开(公告)号：KR1020120035471A
公开(公告)日：2012-04-16
申请号：KR1020100096995
申请日：2010-10-05
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A method for analyzing metabolic differentiation of hair samples based on quantitative steroid signature is provided to evaluate endocrine disease and biological changes related to steroid hormones. CONSTITUTION: A method for analyzing metabolic differentiation of hair samples includes the following: hair samples are decomposed based on ultrasound wave; steroid hormone biological metabolites including androgen, progesterone, sterol, and adrenocortical hormones are simultaneously extracted; steroid hormone is re-extracted from the metabolites using copolymer absorber; the re-extracted product is trimethylsilyl derivatizated; and the concentration of the metabolites is measured based on a gas chromatography-mass spectrometry.
Abstract translation: 目的：提供一种基于定量类固醇特征分析头发样本代谢分化的方法，以评估与类固醇激素相关的内分泌疾病和生物学变化。 构成：分析头发样本代谢分化的方法包括：头发样品根据超声波分解; 同时提取类固醇激素生物代谢物，包括雄激素，孕激素，固醇和肾上腺皮质激素; 使用共聚物吸收剂从代谢物中再次提取类固醇激素; 再提取产物是衍生的三甲基甲硅烷基化物; 并且基于气相色谱 - 质谱法测量代谢物的浓度。
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9.发明公开
公开(公告)号：KR1020130007704A
公开(公告)日：2013-01-21
申请号：KR1020110067573
申请日：2011-07-07
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A method for directly analyzing a biocompound in blood from a blood sample stained on paper is provided to directly analyze the biocompound and to enable quick and reproducible analysis. CONSTITUTION: A method for directly analyzing a biocompound from a blood sample on a sheet of paper comprises: a step of staining the blood sample on the paper; a step of applying alpha-cyano-4-hydroxy cinnamic acid onto the paper and crystallizing in a thin film form; and a step of detecting the biocompound in the blood using laser desorption/ionization-mass spectrometry. The biocompound contains choline or heme B. The crystallization is performed by spraying alpha-cyano-4-hydroxy cinnamic acid onto the blood sample. The thickness of the paper is 150-500 um.
Abstract translation: 目的：提供一种从纸上染色的血液样品中直接分析血液中生物体的方法，直接分析生物化合物，实现快速，可重复的分析。 构成：在一张纸上从血液样品直接分析生物化合物的方法包括：将纸上的血液样品染色的步骤; 将α-氰基-4-羟基肉桂酸施加到纸上并以薄膜形式结晶的步骤; 以及使用激光解吸/电离 - 质谱法检测血液中的生物体的步骤。 生物化合物含有胆碱或血红素B.通过将α-氰基-4-羟基肉桂酸喷雾到血液样品上进行结晶。 纸的厚度为150-500微米。
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公开(公告)号：KR101159064B1
公开(公告)日：2012-07-11
申请号：KR1020100120928
申请日：2010-11-30
Applicant: 한국과학기술연구원
IPC: G01N30/72 , G01N33/60 , G01N33/74 , G01N33/487
Abstract: 본 발명은 생체 시료 내 활성 남성호르몬의 신속하고 정확한 정량 방법에 관한 것이다.
본 발명은 동위원소가 치환된 내부표준물질을 첨가하여 소변, 혈액 등과 같은 생체 시료로부터 테스토스테론을 포함한 활성 남성호르몬들을 효과적으로 추출 및 정량 분석할 수 있으므로, 생체 시료 내 남성호르몬의 농도 및 이의 분포 경향을 파악할 수 있다. 따라서 본 발명은 남성호르몬의 농도 분포를 통해 탈모 환자와 탈모 관련 치료제의 평가를 위한 자료를 제공하는데 적용될 수 있다.
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