-
公开(公告)号：WO2012036506A2
公开(公告)日：2012-03-22
申请号：PCT/KR2011/006853
申请日：2011-09-16
IPC: A61K36/282 , A61K36/235 , A61K36/31 , A61P25/28 , A61P25/00
CPC classification number: A61K36/57 , A61K36/282 , A61K36/31 , A61K2300/00
Abstract: 본 발명은 청호 (Artemisia apiaceae) 추출물, 팔각회향 (Illicium verum) 추출물 및 정력자 (Lepidium apefalum) 추출물로 구성된 군으로부터 선택되는 하나 또는 둘 이상의 식물 추출물을 유효성분으로 포함하는 기억력 또는 학습 능력 증진용 조성물 및 인지기능장애 예방 및 치료용 조성물에 관한 것이다. 본 발명은 아세틸콜린스테라아제의 활성을 억제, 항산화 활성(예컨대, 활성산소종) 및 NMDA 리셉터와의 친화력을 통하여 신경세포, 특히 대뇌 기저부의 신경세포의 손상을 억제시킬 수 있는 효과를 가진다. 본 발명은 신경세포를 보호 및 손상의 예방 효과를 통하여 기억력 또는 학습 능력을 증진시킬 수 있을 뿐 만 아니라 인지기능장애로 질환을 예방 및 치료 할 수 있는 효능을 발휘한다. 또한, 본 발명은 기억력 또는 학습 능력의 증진 효능, 또는 인지기능장애를 예방 및 치료 효능을 가지는 정력자 추출물의 의약 및 식품으로서의 기초적인 자료를 제공한다.
Abstract translation: 本发明涉及一种用于促进记忆或学习能力的组合物和用于预防和治疗认知障碍的组合物，其包含一种，两种或更多种选自蒿蒿提取物，ium藜提取物和韭菜提取物的植物提取物 。 本发明通过抑制乙酰胆碱酯酶活性和通过抗氧化活性（例如，抑制氧化反应物质的产生）和对NMDA受体的亲和力，具有抑制神经细胞损伤，特别是抑制大脑基底部分的神经细胞的作用。 本发明的组合物可以具有不仅通过保护神经细胞并防止对神经细胞的损伤而且通过预防和治疗由认知障碍引起的疾病而促进记忆或学习能力的效果。 此外，根据本发明，提供了作为用于促进记忆或学习能力或预防和治疗认知障碍的功效的药物或食品的基本材料。
-
公开(公告)号：KR101317320B1
公开(公告)日：2013-10-11
申请号：KR1020110078568
申请日：2011-08-08
Applicant: 한국식품연구원
IPC: A61K36/282 , A61P25/28 , A61P25/00
Abstract: 본 발명은 청호 추출물을 유효성분으로 포함하는 기억력 및 학습 능력 증진용 조성물 및 인지기능장애 예방 및 치료용 조성물에 관한 것이다. 본 발명은 아세틸콜린스테라아제의 활성을 억제, 항산화 활성(예컨대, 활성산소종) 및 NMDA 리셉터와의 친화력을 통하여 신경세포, 특히 대뇌 기저부의 신경세포의 손상을 억제시킬 수 있는 효과를 가진다. 본 발명은 신경세포를 보호 및 손상의 예방 효과를 통하여 기억력 및 학습 능력을 증진시킬 수 있을 뿐 만 아니라 인지기능장애로 질환을 예방 및 치료 할 수 있는 효능을 발휘한다. 또한, 본 발명은 기억력 및 학습 능력의 증진 효능, 또는 인지기능장애를 예방 및 치료 효능을 가지는 청호 추출물의 의약 및 식품으로서의 기초적인 자료를 제공한다.
-
公开(公告)号：KR1020120029992A
公开(公告)日：2012-03-27
申请号：KR1020110078568
申请日：2011-08-08
Applicant: 한국식품연구원
IPC: A61K36/282 , A61P25/28 , A61P25/00
Abstract: PURPOSE: A composition for improving memory power and learning ability comprising extract from artemisia apiaceae as active ingredient is provided to control antioxidant activity and activity of acetylcholinesterase. CONSTITUTION: A composition for improving memory power and learning ability including Artemisia apiaceae extract as an active ingredient. A composition for preventing or treating cognitive disorder includes the Artemisia apiaceae extract as the active ingredient. The compositions for improving memory power, learning ability, and preventing or treating cognitive disorder have several functions as follow: suppressing activity of Acetylcholinesterase, antioxidant activity, controlling or eliminating generation of reactive oxygen species, acting as antagonist [antagonist of NMDA[N-methyl-D-aspartate] receptor. The cognitive disorder stands for dementia, formerly LDH, agnosia, amnesia, aphasia, parectropia, or delirium. A pharmaceutical composition for preventing or treating cognitive disorder includes therapeutic effective amount of composition including Artemisia apiaceae extracts and pharmaceutically allowed carrier.
Abstract translation: 目的：提供一种用于提高记忆力和学习能力的组合物，其包括作为活性成分的姬松蒿提取物，以控制乙酰胆碱酯酶的抗氧化活性和活性。 构成：用于提高记忆力和学习能力的组合物，包括蒿科植物提取物作为活性成分。 用于预防或治疗认知障碍的组合物包括蒿科艾蒿提取物作为活性成分。 用于提高记忆力，学习能力和预防或治疗认知障碍的组合物具有以下功能：抑制乙酰胆碱酯酶的活性，抗氧化活性，控制或消除作为拮抗剂的活性氧的产生[NMDA [N-甲基 -D-天冬氨酸]受体。 认知障碍代表痴呆，以前称为LDH，恶性呕吐症，遗忘症，失语症，副作用或del妄。 用于预防或治疗认知障碍的药物组合物包括治疗有效量的组合物，包括蒿科植物提取物和药学上允许的载体。
-
公开(公告)号：KR1020110125959A
公开(公告)日：2011-11-22
申请号：KR1020100045617
申请日：2010-05-14
Applicant: 한국식품연구원
IPC: A61K36/704 , A61P7/02
CPC classification number: A61K36/704 , A23V2200/326 , A61K2236/333 , Y10S514/822
Abstract: PURPOSE: A pharmaceutical composition containing Polygonum multiflorum extract for reducing blood clot is provided to prevent and relieve adult diseases such as heart disease and stroke. CONSTITUTION: A pharmaceutical composition for reducing blood clot contains Polygonum multiflorum ethanol extract as an active ingredient. The ethanol is 70-90% ethanol. A functional food with an activity of reducing blood clot contains the Polygonum multiflorum ethanol extract as an active ingredient. The Polygonum multiflorum extract is contained in 0.02-50 wt% based on total pharmaceutical composition. The pharmaceutical composition is manufactured in the form of powder, granules, tablets, capsules, suspensions, syrup, external use formulation, and suppository.
Abstract translation: 目的：提供一种含有减少血块的茯苓提取物的药物组合物，用于预防和缓解成人疾病如心脏病和中风。 构成：用于减少血块的药物组合物含有枸杞多酚乙醇提取物作为活性成分。 乙醇为70-90％乙醇。 具有减少血块活性的功能性食品含有枸杞多酚乙醇提取物作为活性成分。 茯苓提取物含量为基于总药物组合物的0.02-50重量％。 药物组合物以粉末，颗粒，片剂，胶囊，悬浮液，糖浆，外用制剂和栓剂的形式制备。
-
公开(公告)号：KR101049493B1
公开(公告)日：2011-07-15
申请号：KR1020100092045
申请日：2010-09-17
Applicant: 한국식품연구원
Abstract: PURPOSE: A composition containing Lepidium apefalum extract for enhancing memory and learning ability is provided to prevent or treat cognitive disorder. CONSTITUTION: A composition for enhancing memory and learning ability contains Lepidium apefalum extract as an active ingredient. A pharmaceutical composition for preventing and treating cognitive disorder contains Lepidium apefalum extract as an active ingredient. The Lepidium apefalum extract is prepared using a polar solvent or non-polar solvent. The polar solvent is water, alcohol, acetic acid, DMFO(dimethyl-formamide), and DMSO(dimethyl sulfoxide). The non-polar solvent is acetone, acetonitrile, ethyl acetate, methyl acetate, fluoroalkane, pentane, and hexane.
Abstract translation: 目的：提供含有提取记忆和学习能力的百日咳提取物的组合物，用于预防或治疗认知障碍。 构成：用于提高记忆力和学习能力的组合物，含有韭菜提取物作为活性成分。 一种用于预防和治疗认知障碍的药物组合物，含有虱属的提取物作为活性成分。 使用极性溶剂或非极性溶剂制备韭菜提取物。 极性溶剂是水，乙醇，乙酸，DMFO（二甲基甲酰胺）和DMSO（二甲基亚砜）。 非极性溶剂是丙酮，乙腈，乙酸乙酯，乙酸甲酯，氟烷烃，戊烷和己烷。
-
Patent Agency Ranking
公开(公告)号：KR101162141B1
公开(公告)日：2012-07-05
申请号：KR1020100045607
申请日：2010-05-14
Applicant: 한국식품연구원
IPC: A61K36/704 , A61K36/27 , A61P3/00
Abstract: 본 발명은 적하수오 추출물을 포함하는 혈중 콜레스테롤 저하용 약학 조성물에 관한 것으로, 더욱 상세하게 본 발명은 적하수오(
Polygonum
multiflorum ) 에탄올 추출물을 포함하는 혈중 콜레스테롤 저하용 약학 조성물, 적하수오를 세척, 건조 및 분쇄하고, 70 ~ 90% 에탄올을 가해 초고속 진공 저온 추출기로 90 ~ 98℃에서 5 ~ 7 시간 동안 추출한 후 농축하는 방법에 의해 수득되는 적하수오 에탄올 추출물의 제조방법 및 적하수오 에탄올 추출물을 포함하는 혈중 콜레스테롤 저하 활성을 갖는 기능성 식품을 제공한다.-
公开(公告)号：KR1020110125953A
公开(公告)日：2011-11-22
申请号：KR1020100045607
申请日：2010-05-14
Applicant: 한국식품연구원
IPC: A61K36/704 , A61K36/27 , A61P3/00
CPC classification number: A61K36/704 , A23V2200/3262 , A61K2236/333 , A61K2236/51
Abstract: PURPOSE: A pharmaceutical composition containing Polygonum multiflorum extract for reducing blood cholesterol is provided to prevent and relieve hypercholesterolemia. CONSTITUTION: A pharmaceutical composition for reducing blood cholesterol contains 0.02-50 wt% of Polygonum multiflorum ethanol extract as an active ingredient. The ethanol extract of Polygonum multiflorum is prepared by washing, drying, and pulverizing Polygonum multiflorum, isolating with a ultrahigh speed vacuum extractor of low temperature at 90-98°C for 5-7 hours, and concentrating. A functional food with activity of reducing blood cholesterol contains the ethanol extract as an active ingredient. The pharmaceutical composition is used in the form of powder, granules, tablets, capsules, suspension, emulsion, syrup, or sterilization injection solution.
Abstract translation: 目的：提供含有降低血液胆固醇的枸杞提取物的药物组合物，以预防和缓解高胆固醇血症。 构成：用于降低血液胆固醇的药物组合物含有0.02-50重量％的枸杞多酚乙醇提取物作为活性成分。 通过洗涤，干燥和粉碎Poly is制备Poly The的乙醇提取物，用超低速真空提取器在90-98℃下分离5-7小时，并浓缩。 具有降低血液胆固醇活性的功能性食品含有乙醇提取物作为活性成分。 药物组合物以粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆或灭菌注射溶液的形式使用。
-
公开(公告)号：KR1020110125962A
公开(公告)日：2011-11-22
申请号：KR1020100045621
申请日：2010-05-14
Applicant: 한국식품연구원
IPC: A61K36/27 , A61K36/704 , A61P9/00
Abstract: PURPOSE: A pharmaceutical composition containing Cynanchum wilfordii extract is provided to reduce blood pressure and to prevent and treat hypertension. CONSTITUTION: A pharmaceutical composition for reducing blood pressure contains Cynanchum wilfordii ethanol extract as an active ingredient. A functional food with an activity of reducing blood pressure contains 0.02-50 wt% of the Cynanchum wilfordii ethanol extract as an active ingredient. The pharmaceutical composition is manufactured in the form of powder, granules, tablets, capsules, suspension, emulsion, syrup, external use formulation, supporsitory, and sterilization injection solution. The Cynanchum wilfordii extract is administered in 0.0001-100mg/kg a day.
Abstract translation: 目的：提供含有西葫芦提取物的药物组合物，以降低血压和预防和治疗高血压。 构成：用于降低血压的药物组合物含有Cynanchum wilfordii乙醇提取物作为活性成分。 具有降低血压活性的功能性食品含有作为活性成分的Cynanchum wilfordii乙醇提取物的0.02〜50重量％。 药物组合物以粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆，外用制剂，促进剂和杀菌注射溶液的形式制备。 Cynanchum wilfordii提取物每天以0.0001-100mg / kg施用。
-
公开(公告)号：KR1020110125960A
公开(公告)日：2011-11-22
申请号：KR1020100045618
申请日：2010-05-14
Applicant: 한국식품연구원
IPC: A61K36/27 , A61K36/704 , A61P7/02
Abstract: PURPOSE: A pharmaceutical composition containing Cynanchum wilfordii extract for reducing blood clot is provided to prevent and relieve heart diseases and stroke. CONSTITUTION: A pharmaceutical composition for reducing blood clot contains 0.02-50 wt% of Cynanchum wilfordii ethanol extract as an active ingredient. The Cynanchum wilfordii extract is prepared by washing, drying, and pulverizing Cynanchum wilfordii and isolating Cynanchum wilfordii using 70-90% ethanol at 90-98°C for 5-7 hours.
Abstract translation: 目的：提供含有枸杞子提取物用于减少血块的药物组合物，以预防和缓解心脏病和中风。 构成：用于减少血块的药物组合物含有0.02-50重量％的Cynanchum wilfordii乙醇提取物作为活性成分。 通过洗涤，干燥和粉碎，藜，并使用70-90％乙醇在90-98℃下分离Cynanchum wilfordii 5-7小时来制备C藜提取物。
-
10.发明公开자바강황의 추출물, 커큐민, 디메톡시커큐민 및 잔소리졸로 구성된 군으로부터 선택되는 하나 이상을 포함하는 기억력 및 학습 능력 증진용 조성물 无效用于提高存储能力的组合物和包含至少一种选自CURCUMA XANTHORRHIZAE EXTRACTS，CURCUMIN，DEMETHOXYCURCUMIN，XANTHORRHIZOL
公开(公告)号：KR1020140044351A
公开(公告)日：2014-04-14
申请号：KR1020140031271
申请日：2014-03-17
Applicant: 한국식품연구원
IPC: A61K31/05 , A61K31/045 , A61P25/28 , A61P25/00
Abstract: The present invention relates to a composition comprising at least one selected from the group consisting of Curcuma xanthorrhizae extract, curcumin, demethoxycurcumin, and xanthorrhizol for improving memory and learning ability. The composition of the present invention particularly has an effect of suppressing damage of nerve cells in cerebrum fundus by inhibiting activity of acetylcholinesterase. In addition, the composition of the present invention not only can improve memory and learning ability via effects of nerve cell protection and damage prevention, but also can prevent and treat cognitive disorders.
Abstract translation: 本发明涉及包含选自姜黄黄体提取物，姜黄素，去甲氧基姜黄素和黄原胶中的至少一种的组合物，用于提高记忆和学习能力。 本发明的组合物特别具有通过抑制乙酰胆碱酯酶的活性来抑制脑底神经细胞的损伤的效果。 此外，本发明的组合物不仅可以通过神经细胞保护和损伤预防的效果来提高记忆力和学习能力，而且可以预防和治疗认知障碍。
-
-
-
-
-
-
-
-
-
Search Results
16
records
(took 0.021 seconds)
