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    3,4,5-tri-substituted cinnamides
    1.
    发明授权
    3,4,5-tri-substituted cinnamides 失效
    3,4,5-三取代的CINNAMIDES

    公开(公告)号：US3801636A

    公开(公告)日：1974-04-02

    申请号：US3801636D

    申请日：1971-08-13

    Applicant: ABBOTT LAB

    Inventor： HORROM B

    IPC: C07C233/12 ,  C07C103/28

    CPC classification number: C07C233/12

    Abstract: COVERS COMPOUND OF THE FORMULA:

    1,3-DI(Y-),2-X,5-(D-CO-CH=CH-)BENZENE

    WHERE X IS SELECTED FROM THE GROUP CONSISTING OF NH2, NH-LOWERALKYL AND N(LOWERALKYL)2; EACH Y IS A HALOGEN SELECTED FROM THE GROUP CONSISTING OF CHLORINE, BROMINE, FLUORINE AND IODINE; AND D IS AN ORGANIC RADICAL CONTAINING A NITROGEN ATOM; AND PHARMACEUTICALLY-ACCEPTABLE ADDITION SALTS THEREOF. ALSO COVERS THEIR USE AS ANTI-DEPRESSANT DRUGS. IN ADDITION COVERS VARIOUS NOVEL INTERMEDIATES USED IN PREPARING THE ABOVE COMPOUNDS.

    Disubstituted propionamides
    2.
    发明授权
    Disubstituted propionamides 失效
    消除性促炎

    公开(公告)号：US3733339A

    公开(公告)日：1973-05-15

    申请号：US3733339D

    申请日：1970-10-05

    Applicant: ABBOTT LAB

    Inventor： HORROM B

    IPC: C07D205/04 ,  C07D13/10

    CPC classification number: C07D205/04

    Abstract: A NOEL SERIES OF N-SUBSTITUTED 3-HALO-2,2-DIMETHYLPROPIONAMIDES. THE COMPOUNDS ARE USEFUL AS INTERMEDIATES FOR PREPARING SUBSTITUTED 1-(PHENLISOPROPYL)-3,3-DIMETHYL AZETIDINES. THESE AZETIDINE COMPOUNDS EXHIBIT MARKED ACTIVITY AS ANORETIC AGENTS.

    5.
    发明专利
    未知

    公开(公告)号：BR6352637D0

    公开(公告)日：1973-07-17

    申请号：BR15263763

    申请日：1963-09-09

    Applicant: ABBOTT LAB

    Inventor： HORROM B

    IPC: C07C233/12

    Abstract: The invention comprises compounds of general formula wherein R is methoxy or amino and R1 and R11 are alkyl (1-7 C); and their preparation by reacting a compound RClCl-Ph-COR111, wherein R111 is hydroxy, alkoxy, bromine or chlorine, with a compound H2N-CR1R11-C­CH, employed when the acid halides are used. Pharmaceutical compositions (e.g. tablets, capsules, solutions) containing compounds I are mentioned. The compounds have tranquillizing, muscle-relaxant and anti-convulsant activity.

    8.
    发明专利
    未知

    公开(公告)号：BR6352638D0

    公开(公告)日：1973-07-17

    申请号：BR15263863

    申请日：1963-09-09

    Applicant: ABBOTT LAB

    Inventor： HORROM B

    IPC: C07C233/12

    Abstract: The invention comprises compounds of formula wherein n is 0 or 1 and R and R1 are alkyl radicals having 1 to 4 carbon atoms, and their preparation by reaction of a compound of formula wherein R is a chlorine or bromine atom, a hydroxy group or an alkoxy group having 1 to 4 carbon atoms, with a dialkyl propynylamine. The compounds of the invention have muscle-relaxing, tranquilizing and anti-convulsant activity, and may be used in pharmaceutical compositions in combination with a carrier in forms suitable for oral or parenteral administration, such as tablets, capsules and solutions.

    9.
    发明专利
    未知

    公开(公告)号：BR6023958D0

    公开(公告)日：1973-05-17

    申请号：BR12395860

    申请日：1960-11-03

    Applicant: ABBOTT LAB

    Inventor： HORROM B

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