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1.发明申请TRUNCATED HUMAN VITAMIN D BINDING PROTEIN AND MUTATION AND FUSION THEREOF AND RELATED MATERIALS AND METHODS OF USE 审中-公开截短人维生素D结合蛋白及其相关材料及其使用方法
公开(公告)号：WO2013102149A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/072189
申请日：2012-12-28
Applicant: ABBOTT LABORATORIES
Inventor： BECKERT, Christian , BROPHY, Susan, E. , GROTE, Jonathan , HUANG, Dagang , SCHULTESS, Jan , TU, Bailin
CPC classification number: G01N33/82 , C07K14/47 , C07K14/76 , C07K2319/00 , C07K2319/30 , C07K2319/40 , G01N33/543
Abstract: Vitamin D binding proteins (DBP), in particular truncated DBP and mutated, truncated DBP, as well as fusion proteins thereof, nucleic acid molecules encoding same, vectors, host cells, and methods, kits and solid supports for determining the total amount of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in a test sample.
Abstract translation: 维生素D结合蛋白（DBP），特别是截短的DBP和突变的截短的DBP，以及其融合蛋白，编码相同的核酸分子，载体，宿主细胞和方法，试剂盒和固体支持物，用于确定总量为25 - 羟基维生素D2和25-羟基维生素D3。
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2.发明申请HAPTENS, TRACERS, IMMUNOGENS AND ANTIBODIES FOR IMMUNOASSAYS FOR PROPOXYPHENE 审中-公开嗜酸性粒细胞，免疫调节剂和免疫原抗体
公开(公告)号：WO1993003344A2
公开(公告)日：1993-02-18
申请号：PCT/US1992006297
申请日：1992-07-22
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , DUBLER, Robert, E. , GROTE, Jonathan , KUHN, Donna, R.
IPC: G01N0
CPC classification number: G01N33/533 , C07K16/44 , G01N33/9486 , Y10S436/815
Abstract: Disclosed is a substantially optically pure hapten, useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene. The hapten corresponds to a specified structural formula (IX). Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten. Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immuoassay for dextropropoxyphene and/or nordextropropoxyphene. Also disclosed is an improved immunoassay for determining dextropropoxyphene and/or nordextropropoxyphene in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen. Also disclosed is a fluorescence polarization immunoassay (FPIA) for determining dextropropoxyphene and/or nordextropropoxyphene involving a step of contacting the sample with antibodies raised in response to the immunogen, and/or involving a step of contacting the sample with a fluorescent tracer.
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Patent Agency Ranking
公开(公告)号：WO1996002839A1
公开(公告)日：1996-02-01
申请号：PCT/US1995007642
申请日：1995-06-16
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , MURRAY, Adrian, John , GROTE, Jonathan , ST. JOHN, Sherri, J. , THUT, Diethild
IPC: G01N33/58
CPC classification number: G01N33/5306 , G01N33/533 , G01N33/582
Abstract: The present invention provides a method for generating an enhanced chemiluminescent signal from an acridinium sulfonamide compound, the method comprising the step of contacting the acridinium sulfonamide compound with a trigger solution in the presence of an enhancer to obtain a chemiluminescent signal which is stronger than would otherwise be generated in the absence of said enhancer. The enhancer comprises at least one member selected from the group consisting of nonionic surfactants, zwitterionic surfactants, and anionic surfactants.
Abstract translation: 本发明提供了一种从吖啶磺酰胺化合物产生增强的化学发光信号的方法，该方法包括在增强剂存在下使吖啶磺酰胺化合物与触发溶液接触的步骤，以获得比其它方法更强的化学发光信号 在不存在所述增强子的情况下产生。 增强剂包括选自非离子表面活性剂，两性离子表面活性剂和阴离子表面活性剂中的至少一种。
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4.发明公开HAPTENS, TRACERS, IMMUNOGENS AND ANTIBODIES FOR IMMUNOASSAYS FOR PROPOXYPHENE 失效半抗原，TRACER，免疫测定法丙氧芬免疫原性的抗体。
公开(公告)号：EP0597034A1
公开(公告)日：1994-05-18
申请号：EP92917936.0
申请日：1992-07-22
Applicant: ABBOTT LABORATORIES
Inventor： DUBLER, Robert, E. , GROTE, Jonathan , KUHN, Donna, R.
CPC classification number: G01N33/533 , C07K16/44 , G01N33/9486 , Y10S436/815
Abstract: L'invention décrit un haptène sensiblement optiquement pur utile dans une immunoanalyse aux fins de la détection de dextropropoxyphène et/ou nordextropropoxyphène. L'haptène correspond à une formule de structure spécifique (IX). Sont également décrits un immunogène dérivé de l'haptène ainsi qu'un anticorps développé en réponse à un immunogène dérivé de l'haptène. L'invention décrit également un traceur fluorescent dérivé d'un composé sensiblement optiquement pur correspondant à l'haptène, le traceur étant utile dans une immunoanalyse pour la détection de dextropropoxyphène et/ou nordextropropoxyphène. L'invention décrit aussi une immunoanalyse améliorée permettant la détection de dextropropoxyphène et/ou nordextropropoxyphène dans un échantillon biologique, et comportant une étape de mise en contact de l'échantillon avec les anticorps développés en réponse à l'immunogène. L'invention décrit aussi une immunoanalyse de polarisation de fluorescence (FPIA) de détermination du dextropropoxyphène et/ou nordextropropoxyphène comportant une étape de mise en contact de l'échantillon avec des anticorps élevés en réponse à l'immunogène et/ou une étape de mise en contact de l'échantillon avec un traceur fluorescent.
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5.发明授权HAPTENS, TRACERS, IMMUNOGENS AND ANTIBODIES FOR IMMUNOASSAYS FOR PROPOXYPHENE 失效半抗原，TRACER，免疫原性和抗体免疫测定法丙氧芬
公开(公告)号：EP0597034B1
公开(公告)日：2000-05-17
申请号：EP92917936.4
申请日：1992-07-22
Applicant: ABBOTT LABORATORIES
Inventor： DUBLER, Robert, E. , GROTE, Jonathan , KUHN, Donna, R.
IPC: G01N33/531 , G01N33/94 , G01N33/533
CPC classification number: G01N33/533 , C07K16/44 , G01N33/9486 , Y10S436/815
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6.发明公开TRUNCATED HUMAN VITAMIN D BINDING PROTEIN AND MUTATION AND FUSION THEREOF AND RELATED MATERIALS AND METHODS OF USE 审中-公开缩短人体维生素D-结合蛋白，以及融合突变THEREOF及相关材料和使用方法
公开(公告)号：EP2798067A1
公开(公告)日：2014-11-05
申请号：EP12815980.3
申请日：2012-12-28
Applicant: ABBOTT LABORATORIES
Inventor： BECKERT, Christian , BROPHY, Susan, E. , GROTE, Jonathan , HUANG, Dagang , SCHULTESS, Jan , TU, Bailin
CPC classification number: G01N33/82 , C07K14/47 , C07K14/76 , C07K2319/00 , C07K2319/30 , C07K2319/40 , G01N33/543
Abstract: Vitamin D binding proteins (DBP), in particular truncated DBP and mutated, truncated DBP, as well as fusion proteins thereof, nucleic acid molecules encoding same, vectors, host cells, and methods, kits and solid supports for determining the total amount of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in a test sample.
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公开(公告)号：EP0774121A1
公开(公告)日：1997-05-21
申请号：EP95923075.0
申请日：1995-06-16
Applicant: Abbott Laboratories
Inventor： MURRAY, Adrian, John , GROTE, Jonathan , ST. JOHN, Sherri, J. , THUT, Diethild
CPC classification number: G01N33/5306 , G01N33/533 , G01N33/582
Abstract: The present invention provides a method for generating an enhanced chemiluminescent signal from an acridinium sulfonamide compound, the method comprising the step of contacting the acridinium sulfonamide compound with a trigger solution in the presence of an enhancer to obtain a chemiluminescent signal which is stronger than would otherwise be generated in the absence of said enhancer. The enhancer comprises at least one member selected from the group consisting of nonionic surfactants, zwitterionic surfactants, and anionic surfactants.
Abstract translation: 本发明提供了从吖啶鎓磺酰胺化合物产生增强的化学发光信号的方法，所述方法包括在增强剂存在下使吖啶鎓磺酰胺化合物与引发剂溶液接触以获得化学发光信号的步骤， 在没有所述增强剂的情况下产生。 增强剂包含至少一种选自非离子表面活性剂，两性离子表面活性剂和阴离子表面活性剂的成员。
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