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公开(公告)号：WO1994008992A1
公开(公告)日：1994-04-28
申请号：PCT/US1993009662
申请日：1993-10-08
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , ABREO, Melwyn, A. , GUNN, David, E. , LIN, Nan-Horng , ELLIOTT, Richard, L. , GARVEY, David, S. , LEBOLD, Suzanne, A. , WASICAK, James, T.
IPC: C07D401/12
CPC classification number: C07D401/12 , C07D403/12 , C07D417/12
Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.
Abstract translation: 具体定义的其中A，B和R 2的式（I）的新型杂环醚化合物或其药学上可接受的盐或前药，其是胆碱能通道受体的选择性和有效配体，可用于治疗认知， 以胆碱能功能下降为特征的神经和精神障碍。
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公开(公告)号：WO1998025920A1
公开(公告)日：1998-06-18
申请号：PCT/US1997022811
申请日：1997-12-10
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , HOLLADAY, Mark, W. , ARNERIC, Stephen, P. , BAI, Hao , DART, Michael, J. , LIN, Nan-Horng , LYNCH, John, K. , OR, Yat, Sun , RYTHER, Keith, B. , SULLIVAN, James, P. , WASICAK, James, T. , EHRLICH, Paul, P.
IPC: C07D401/12
CPC classification number: C07D401/12 , A61K31/4427 , A61K31/485 , C07D205/04 , Y02P20/55 , A61K2300/00
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
Abstract translation: 本发明涉及一种控制包括人在内的哺乳动物疼痛的方法，包括向需要治疗的哺乳动物或患者施用选择的式（I）化合物或其药学上可接受的盐。 本发明进一步涉及可用作止痛剂以及神经元细胞死亡预防剂和抗炎剂的式（I）的选择的（R）和（S）化合物。
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3.发明申请FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 审中-公开丙烯酰胺，三烯丙基吡咯烷酮，吡咯并吡啶和相关的吡咯胺，吡嗪和三嗪化合物在控制化学反应中的应用
公开(公告)号：WO1997005139A1
公开(公告)日：1997-02-13
申请号：PCT/US1996012274
申请日：1996-07-25
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , ELLIOTT, Richard, L. , RYTHER, Keith, B. , HOLLADAY, Mark, W. , WASICAK, James, T. , DAANEN, Jerome, F.
IPC: C07D491/044
CPC classification number: C07D471/04 , A61K31/4355 , C07D487/04 , C07D491/04 , C07D495/04
Abstract: Novel heterocyclic ether compounds having the formula (I) wherein A, m, R, X, Y , Y and Y are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.
Abstract translation: 具有式（I）的新型杂环醚化合物，其中A，m，R，X，Y 1，Y 2和Y 3是特别限定的，其可用于选择性地控制化学突触传递; 其治疗有效的药物组合物; 以及使用所述组合物来选择性地控制哺乳动物中的突触传递。
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4.发明授权FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 失效呋喃，噻吩并吡咯并吡啶及及相关PYRINIDIN-，哒嗪和三嗪非常适合控制化学突触传递
公开(公告)号：EP0842178B1
公开(公告)日：2001-03-28
申请号：EP96926133.8
申请日：1996-07-25
Applicant: Abbott Laboratories
Inventor： ELLIOTT, Richard, L. , RYTHER, Keith, B. , HOLLADAY, Mark, W. , WASICAK, James, T. , DAANEN, Jerome, F.
IPC: C07D491/044 , C07D519/00 , A61K31/435 , C07D471/04
CPC classification number: C07D471/04 , A61K31/4355 , C07D487/04 , C07D491/04 , C07D495/04
Abstract: Novel heterocyclic ether compounds having the formula (I) wherein A, m, R, X, Y?1, Y2 and Y3¿ are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.
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Patent Agency Ranking5.发明授权7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 失效图7A-取代六氢-1H-吡咯嗪非常适合控制化学突触传递的
公开(公告)号：EP0970083B1
公开(公告)日：2003-04-16
申请号：EP98907359.8
申请日：1998-02-05
Applicant: Abbott Laboratories
Inventor： WASICAK, James, T. , GARVEY, David, S. , HOLLADAY, Mark, W. , LIN, Nan-Horng , RYTHER, Keith, B.
IPC: C07D487/04 , A61K31/44
CPC classification number: C07D487/04
Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having formula (I), wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.
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6.发明公开FUROPYRIDINE, THIENOPYRIDINE, PYRROLOPYRIDINE AND RELATED PYRIMIDINE, PYRIDAZINE AND TRIAZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 失效呋喃，噻吩并吡咯并吡啶及及相关PYRINIDIN-，哒嗪和三嗪非常适合控制化学突触传递
公开(公告)号：EP0842178A1
公开(公告)日：1998-05-20
申请号：EP96926133.0
申请日：1996-07-25
Applicant: Abbott Laboratories
Inventor： ELLIOTT, Richard, L. , RYTHER, Keith, B. , HOLLADAY, Mark, W. , WASICAK, James, T. , DAANEN, Jerome, F.
CPC classification number: C07D471/04 , A61K31/4355 , C07D487/04 , C07D491/04 , C07D495/04
Abstract: Novel heterocyclic ether compounds having the formula (I) wherein A, m, R, X, Y?1, Y2 and Y3¿ are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.
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公开(公告)号：EP0950057B1
公开(公告)日：2002-11-13
申请号：EP97952392.5
申请日：1997-12-10
Applicant: Abbott Laboratories
Inventor： HOLLADAY, Mark, W. , ARNERIC, Stephen, P. , BAI, Hao , DART, Michael, J. , LIN, Nan-Horng , LYNCH, John, K. , OR, Yat, Sun , RYTHER, Keith, B. , SULLIVAN, James, P. , WASICAK, James, T. , EHRLICH, Paul, P.
IPC: C07D401/12 , A61K31/44 , C07D205/04
CPC classification number: C07D401/12 , A61K31/4427 , A61K31/485 , C07D205/04 , Y02P20/55 , A61K2300/00
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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8.发明公开7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 失效图7A-取代六氢-1H-吡咯嗪非常适合控制化学突触传递的
公开(公告)号：EP0970083A1
公开(公告)日：2000-01-12
申请号：EP98907359.8
申请日：1998-02-05
Applicant: Abbott Laboratories
Inventor： WASICAK, James, T. , GARVEY, David, S. , HOLLADAY, Mark, W. , LIN, Nan-Horng , RYTHER, Keith, B.
IPC: C07D487/04 , A61K31/44
CPC classification number: C07D487/04
Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having formula (I), wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.
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公开(公告)号：EP0950057A1
公开(公告)日：1999-10-20
申请号：EP97952392.0
申请日：1997-12-10
Applicant: Abbott Laboratories
Inventor： HOLLADAY, Mark, W. , ARNERIC, Stephen, P. , BAI, Hao , DART, Michael, J. , LIN, Nan-Horng , LYNCH, John, K. , OR, Yat, Sun , RYTHER, Keith, B. , SULLIVAN, James, P. , WASICAK, James, T. , EHRLICH, Paul, P.
CPC classification number: C07D401/12 , A61K31/4427 , A61K31/485 , C07D205/04 , Y02P20/55 , A61K2300/00
Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.
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