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公开(公告)号：WO1994008992A1
公开(公告)日：1994-04-28
申请号：PCT/US1993009662
申请日：1993-10-08
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , ABREO, Melwyn, A. , GUNN, David, E. , LIN, Nan-Horng , ELLIOTT, Richard, L. , GARVEY, David, S. , LEBOLD, Suzanne, A. , WASICAK, James, T.
IPC: C07D401/12
CPC classification number: C07D401/12 , C07D403/12 , C07D417/12
Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.
Abstract translation: 具体定义的其中A，B和R 2的式（I）的新型杂环醚化合物或其药学上可接受的盐或前药，其是胆碱能通道受体的选择性和有效配体，可用于治疗认知， 以胆碱能功能下降为特征的神经和精神障碍。
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2.发明申请BICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS 审中-公开BICYCLIC取代HEXAHYDROBENZ [E] ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS
公开(公告)号：WO1996022991A1
公开(公告)日：1996-08-01
申请号：PCT/US1996000178
申请日：1996-01-11
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , PRATT, John, K. , SIPPY, Kevin, B. , TIETJE, Karin, R. , YAMAMOTO, Diane, M.
IPC: C07D487/02
CPC classification number: C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W是双环杂环体系。 这些化合物是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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3.发明申请TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS 审中-公开TRICYCLIC替代HEXAHYDROBENZ [E] ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS
公开(公告)号：WO1996022992A1
公开(公告)日：1996-08-01
申请号：PCT/US1996000072
申请日：1996-01-11
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , ELMORE, Steven, W. , SIPPY, Kevin, B. , TIETJE, Karin, R. , WENDT, Michael, D. , YAMAMOTO, Diane, M.
IPC: C07D495/04
CPC classification number: C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中W是三环杂环体系; 其是α-1肾上腺素能拮抗剂，可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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4.发明公开TRICYCLIC SUBSTITUTED HEXAHYDROBENZ E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS 失效三环取代六氢苯并（E）异吲哚α-1肾上腺素能拮抗剂
公开(公告)号：EP0808318A1
公开(公告)日：1997-11-26
申请号：EP96903340.0
申请日：1996-01-11
Applicant: Abbott Laboratories
Inventor： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , ELMORE, Steven, W. , SIPPY, Kevin, B. , TIETJE, Karin, R. , WENDT, Michael, D. , YAMAMOTO, Diane, M.
CPC classification number: C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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Patent Agency Ranking5.发明公开HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 有权杂环醚和硫醚类化合物适用于控制化学突触传递
公开(公告)号：EP1047690A1
公开(公告)日：2000-11-02
申请号：EP98964167.5
申请日：1998-12-18
Applicant: Abbott Laboratories
Inventor： HOLLADAY, Mark, W. , ABREO, Melwyn, A. , GUNN, David, E. , LIN, Nan-Horng , GARVEY, David, S. , RYTHER, Keith , LEBOLD, Suzanne, A. , ELLIOTT, Richard, L. , HE, Yun , WASIAK, James, T. , BAI, Hao , DART, Michael, J. , EHRLICH, Paul, P. , LI, Yihong , KINCAID, John, F. , SCHKERYANTZ, Jeffrey, M. , LYNCH, John, K.
IPC: C07D401/12 , C07D403/12 , C07D417/12 , C07D487/04 , C07D455/02 , A61K31/44 , A61K31/40 , A61K31/425 , A61K31/50 , A61K31/505 , A61K31/47
CPC classification number: C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04
Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.
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6.发明授权HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION 有权杂环醚和硫醚类化合物适用于控制化学突触传递
公开(公告)号：EP1047690B1
公开(公告)日：2004-03-24
申请号：EP98964167.5
申请日：1998-12-18
Applicant: Abbott Laboratories
Inventor： HOLLADAY, Mark, W. , ABREO, Melwyn, A. , GUNN, David, E. , LIN, Nan-Horng , GARVEY, David, S. , RYTHER, Keith , LEBOLD, Suzanne, A. , ELLIOTT, Richard, L. , HE, Yun , WASIAK, James, T. , BAI, Hao , DART, Michael, J. , EHRLICH, Paul, P. , LI, Yihong , KINCAID, John, F. , SCHKERYANTZ, Jeffrey, M. , LYNCH, John, K.
IPC: C07D401/12 , C07D403/12 , C07D417/12 , C07D487/04 , C07D455/02 , A61K31/44 , A61K31/40 , A61K31/425 , A61K31/50 , A61K31/505 , A61K31/47
CPC classification number: C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04
Abstract: Novel compounds having formulas (I), (II) or (III) or pharmaceutically-acceptable salts or prodrugs thereof, which are useful for controlling synaptic transmission; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to controlling synaptic transmission in human or veterinary patients.
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7.发明公开BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS 失效双环取代的六氢苯并（E）与α-1肾上腺素能拮抗剂活性的异吲哚
公开(公告)号：EP0805812A1
公开(公告)日：1997-11-12
申请号：EP96903364.0
申请日：1996-01-11
Applicant: Abbott Laboratories
Inventor： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , PRATT, John, K. , SIPPY, Kevin, B. , TIETJE, Karin, R. , YAMAMOTO, Diane, M.
IPC: A61K31 , A61P13 , A61P15 , A61P25 , C07D401 , C07D403 , C07D471 , C07D473 , C07D475 , C07D487 , C07D491 , C07D495 , C07D498
CPC classification number: C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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8.发明授权BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS 失效双环取代的六氢苯并（E）与α-1肾上腺素能拮抗剂活性的异吲哚
公开(公告)号：EP0805812B1
公开(公告)日：2001-06-13
申请号：EP96903364.6
申请日：1996-01-11
Applicant: Abbott Laboratories
Inventor： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , PRATT, John, K. , SIPPY, Kevin, B. , TIETJE, Karin, R. , YAMAMOTO, Diane, M.
IPC: C07D487/02 , A61K31/505 , C07D495/02 , C07D475/02 , C07D487/00
CPC classification number: C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D495/04
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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9.发明授权TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS 失效三环取代六氢苯并[E]异吲哚ALPHA-1肾上腺素能受体拮抗剂
公开(公告)号：EP0808318B1
公开(公告)日：2000-06-28
申请号：EP96903340.6
申请日：1996-01-11
Applicant: Abbott Laboratories
Inventor： MEYER, Michael, D. , ALTENBACH, Robert, J. , BASHA, Fatima, Z. , CARROLL, William, A. , DRIZIN, Irene , KERWIN, James, F., Jr. , LEBOLD, Suzanne, A. , LEE, Edmund, L. , ELMORE, Steven, W. , SIPPY, Kevin, B. , TIETJE, Karin, R. , WENDT, Michael, D. , YAMAMOTO, Diane, M.
IPC: C07D495/04 , C07D491/048 , C07D487/04 , C07D403/06 , C07D491/147 , C07D495/14 , C07D487/16 , C07D471/14 , A61K31/395
CPC classification number: C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.
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