公开(公告)号：WO1998025920A1

公开(公告)日：1998-06-18

申请号：PCT/US1997022811

申请日：1997-12-10

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HOLLADAY, Mark, W. ,  ARNERIC, Stephen, P. ,  BAI, Hao ,  DART, Michael, J. ,  LIN, Nan-Horng ,  LYNCH, John, K. ,  OR, Yat, Sun ,  RYTHER, Keith, B. ,  SULLIVAN, James, P. ,  WASICAK, James, T. ,  EHRLICH, Paul, P.

IPC: C07D401/12

CPC classification number: C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

Abstract translation: 本发明涉及一种控制包括人在内的哺乳动物疼痛的方法，包括向需要治疗的哺乳动物或患者施用选择的式（I）化合物或其药学上可接受的盐。 本发明进一步涉及可用作止痛剂以及神经元细胞死亡预防剂和抗炎剂的式（I）的选择的（R）和（S）化合物。

公开(公告)号：WO1996040682A1

公开(公告)日：1996-12-19

申请号：PCT/US1996007804

申请日：1996-05-28

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HOLLADAY, Mark, W. ,  LIN, Nan-Horng ,  RYTHER, Keith, B. ,  HE, Yun

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R , R , A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

Abstract translation: 具有式（I）的新颖的3-吡啶氧基甲基杂环醚化合物，其中*是手性中心，n，X，R 1，R 2，A和B是特别限定的，其可用于控制化学突触传递; 治疗有效的药物组合物; 以及使用所述组合物来选择性地控制哺乳动物中的突触传递。

公开(公告)号：WO2002062762A2

公开(公告)日：2002-08-15

申请号：PCT/US2002/005252

申请日：2002-01-17

Applicant: ABBOTT LABORATORIES

Inventor： ALTENBACH, Robert, J. ,  BAI, Hao ,  BRIONI, Jorge, D. ,  CARROLL, William, A. ,  GOPALAKRISHNAN, Murali ,  GREGG, Robert, J. ,  HOLLADAY, Mark, W. ,  HUANG, Peggy, P. ,  KINCAID, John, F. ,  KORT, Michael, E. ,  KYM, Philip, R. ,  LYNCH, John, K. ,  PEREZ-MEDRANO, Arturo ,  ZHANG, Henry, Q.

IPC: C07D213/75

CPC classification number: C07D213/40 ,  A61K31/17 ,  A61K31/275 ,  A61K31/4406 ,  C07C233/78 ,  C07C233/83 ,  C07C271/22 ,  C07C275/28 ,  C07C275/30 ,  C07C279/28 ,  C07C279/36 ,  C07C335/16 ,  C07C335/18 ,  C07D209/08 ,  C07D213/74 ,  C07D213/75 ,  C07D213/82 ,  C07D215/38 ,  C07D233/42 ,  C07D233/84 ,  C07D235/06 ,  C07D239/42 ,  C07D333/20 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract translation: 式（I）化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。

公开(公告)号：WO1997005139A1

公开(公告)日：1997-02-13

申请号：PCT/US1996012274

申请日：1996-07-25

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ELLIOTT, Richard, L. ,  RYTHER, Keith, B. ,  HOLLADAY, Mark, W. ,  WASICAK, James, T. ,  DAANEN, Jerome, F.

IPC: C07D491/044

CPC classification number: C07D471/04 ,  A61K31/4355 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: Novel heterocyclic ether compounds having the formula (I) wherein A, m, R, X, Y , Y and Y are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

Abstract translation: 具有式（I）的新型杂环醚化合物，其中A，m，R，X，Y 1，Y 2和Y 3是特别限定的，其可用于选择性地控制化学突触传递; 其治疗有效的药物组合物; 以及使用所述组合物来选择性地控制哺乳动物中的突触传递。

公开(公告)号：WO1991019733A1

公开(公告)日：1991-12-26

申请号：PCT/US1991004458

申请日：1991-06-20

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SHIOSAKI, Kazumi ,  NADZAN, Alex, M. ,  KOPECKA, Hana ,  SHUE, Youe-Kona ,  HOLLADAY, Mark, W. ,  LIN, Chun, W. ,  NELLANS, Hugh, N.

IPC: C07K05/00

CPC classification number: C07K5/0215 ,  A61K38/00 ,  C07K5/0207 ,  C07K5/0815 ,  C07K5/0821 ,  C07K5/1016 ,  C07K5/1024 ,  C07K14/595

Abstract: Selective and potent Type-A CCK receptor agonists of formula (I): X-Y-Z-Q, or a pharmaceutically acceptable salt thereof, wherein, X is selected from (a) and (b); Y is selected from (c) and (d); Z is (e); and Q is (f), or pharmaceutically-acceptable salts thereof, useful in the treatment of gastrointestinal disorders (including gallbladder disorders), central nervous system disorders, insuline-related disorders and pain, as well as in appetite regulation.

Abstract translation: 选择性和有效的式（I）的CCK受体激动剂：X-Y-Z-Q或其药学上可接受的盐，其中X选自（a）和（b）; Y选自（c）和（d）; Z是（e）; 和Q是（f）或其药学上可接受的盐，其可用于治疗胃肠道疾病（包括胆囊疾病），中枢神经系统疾病，胰岛素相关疾病和疼痛以及食欲调节。

公开(公告)号：WO1997046554A1

公开(公告)日：1997-12-11

申请号：PCT/US1997009167

申请日：1997-06-04

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LIN, Nan-Horng ,  HE, Yun ,  HOLLADAY, Mark, W. ,  RYTHER, Keith ,  LI, Yihong ,  BAI, Hao

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds of formula (I) or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission. Key intermediates and processes using this key intermediates to produce compounds of formula (I) with the variables defined in the specification are also described.

Abstract translation: 式（I）的新型3-吡啶氧基甲基杂环醚化合物或其药学上可接受的盐或前药是神经元烟碱胆碱能通道受体的选择性和有效配体，并且有效控制突触传递。 还描述了使用这种关键中间体用式（I）化合物与说明书中定义的变量的关键中间体和方法。

公开(公告)号：EP0842178B1

公开(公告)日：2001-03-28

申请号：EP96926133.8

申请日：1996-07-25

Applicant: Abbott Laboratories

Inventor： ELLIOTT, Richard, L. ,  RYTHER, Keith, B. ,  HOLLADAY, Mark, W. ,  WASICAK, James, T. ,  DAANEN, Jerome, F.

IPC: C07D491/044 ,  C07D519/00 ,  A61K31/435 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4355 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: Novel heterocyclic ether compounds having the formula (I) wherein A, m, R, X, Y?1, Y2 and Y3¿ are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：EP1040097A1

公开(公告)日：2000-10-04

申请号：EP98963249.2

申请日：1998-12-16

Applicant: Abbott Laboratories

Inventor： CARROLL, William, A. ,  HOLLADAY, Mark, W. ,  SULLIVAN, James, P. ,  DRIZIN, Irene ,  ZHANG, Henry, Q.

IPC: C07D211/84 ,  C07D215/36 ,  C07D495/04 ,  C07D495/14 ,  A61K31/44 ,  A61K31/47 ,  A61K31/38

CPC classification number: C07D221/04 ,  C07C45/298 ,  C07D215/36 ,  C07D495/04 ,  C07D495/14 ,  C07C47/55

Abstract: Compounds having the formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

公开(公告)号：EP0950057B1

公开(公告)日：2002-11-13

申请号：EP97952392.5

申请日：1997-12-10

Applicant: Abbott Laboratories

Inventor： HOLLADAY, Mark, W. ,  ARNERIC, Stephen, P. ,  BAI, Hao ,  DART, Michael, J. ,  LIN, Nan-Horng ,  LYNCH, John, K. ,  OR, Yat, Sun ,  RYTHER, Keith, B. ,  SULLIVAN, James, P. ,  WASICAK, James, T. ,  EHRLICH, Paul, P.

IPC: C07D401/12 ,  A61K31/44 ,  C07D205/04

CPC classification number: C07D401/12 ,  A61K31/4427 ,  A61K31/485 ,  C07D205/04 ,  Y02P20/55 ,  A61K2300/00

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：EP1102754A1

公开(公告)日：2001-05-30

申请号：EP99939019.8

申请日：1999-08-06

Applicant: ABBOTT LABORATORIES

Inventor： ALTENBACH, Robert, J. ,  MEYER, Michael, D. ,  KERWIN, James, F., Jr. ,  HOLLADAY, Mark, W. ,  KHILEVICH, Albert ,  KOLASA, Teodozyj ,  ROHDE, Jeffrey ,  CARROLL, William, A.

IPC: C07D233/61 ,  A61K31/4164 ,  C07D405/04 ,  C07D413/12 ,  C07D409/12 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D405/12 ,  C07D277/28 ,  C07D263/32 ,  C07D263/48 ,  C07D277/40

CPC classification number: C07D233/64 ,  C07D233/84 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D409/12 ,  C07D417/12

Abstract: Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with α1A agonists. Also disclosed are α1A agonist compositions and a method of activating α1 adrenoceptors in a mammal.