公开(公告)号：US20250108147A1

公开(公告)日：2025-04-03

申请号：US18036218

申请日：2021-11-12

Applicant: ADEKA CORPORATION

Inventor： Mitsumasa HOMMA ,  Kenichiro HIWATARI ,  Haruki OBARA ,  Takuya KIMURA ,  Keita KINOSHITA

IPC: A61L27/36 ,  A61L27/22

Abstract: The object of the present invention is to provide a decellularized tissue that has appropriate strength and exhibits good tissue regeneration.
The problem can be solved by a decellularized tissue composition comprising a decellularized tissue and a protein A with (a) molecular weight of 30,000 to 70,000 and (b) isoelectric point of pI 6.00 to 9.00

公开(公告)号：US20200222589A1

公开(公告)日：2020-07-16

申请号：US16615177

申请日：2018-05-25

Applicant: ADEKA CORPORATION

Inventor： Tetsuya HIGAMI ,  Kenichiro HIWATARI ,  Yu YAMAGUCHI ,  Haruki OBARA ,  Takuya KIMURA ,  Mitsumasa HOMMA ,  Kyohei OCHIAI ,  Keita KINOSHITA ,  Naoki MORIMOTO

IPC: A61L27/36 ,  A61L27/50

Abstract: A method of producing a decellularized transplantation material, wherein the method includes the steps of (a) harvesting a branch-bearing blood vessel from a vertebrate animal (a donor); (b) decellularizing the blood vessel; and (c) adhering, by a protein denaturation treatment, a portion where a branch has been excised to close the vessel. Also, a graft composition consisting of a biocompatible material that contains the decellularized transplantation material.

公开(公告)号：US20180078679A1

公开(公告)日：2018-03-22

申请号：US15556776

申请日：2016-03-07

Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE ,  ADEKA CORPORATION ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  SAPPORO MEDICAL UNIVERSITY

Inventor： Hideki SAGA ,  Takanori UCHIDA ,  Shoko TOKOROZAKI ,  Ken-ichiro HIWATARI ,  Haruki OBARA ,  Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Tetsuya HIGAMI ,  Seiichi FUNAMOTO

IPC: A61L31/04

CPC classification number: A61L31/046 ,  A61L24/106 ,  A61L31/005 ,  A61L31/10 ,  A61L2300/424

Abstract: An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.