公开(公告)号：US20200222589A1

公开(公告)日：2020-07-16

申请号：US16615177

申请日：2018-05-25

Applicant: ADEKA CORPORATION

Inventor： Tetsuya HIGAMI ,  Kenichiro HIWATARI ,  Yu YAMAGUCHI ,  Haruki OBARA ,  Takuya KIMURA ,  Mitsumasa HOMMA ,  Kyohei OCHIAI ,  Keita KINOSHITA ,  Naoki MORIMOTO

IPC: A61L27/36 ,  A61L27/50

Abstract: A method of producing a decellularized transplantation material, wherein the method includes the steps of (a) harvesting a branch-bearing blood vessel from a vertebrate animal (a donor); (b) decellularizing the blood vessel; and (c) adhering, by a protein denaturation treatment, a portion where a branch has been excised to close the vessel. Also, a graft composition consisting of a biocompatible material that contains the decellularized transplantation material.

公开(公告)号：US20180078679A1

公开(公告)日：2018-03-22

申请号：US15556776

申请日：2016-03-07

Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE ,  ADEKA CORPORATION ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  SAPPORO MEDICAL UNIVERSITY

Inventor： Hideki SAGA ,  Takanori UCHIDA ,  Shoko TOKOROZAKI ,  Ken-ichiro HIWATARI ,  Haruki OBARA ,  Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Tetsuya HIGAMI ,  Seiichi FUNAMOTO

IPC: A61L31/04

CPC classification number: A61L31/046 ,  A61L24/106 ,  A61L31/005 ,  A61L31/10 ,  A61L2300/424

Abstract: An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.

公开(公告)号：US20240316250A1

公开(公告)日：2024-09-26

申请号：US18734282

申请日：2024-06-05

Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  SAPPORO MEDICAL UNIVERSITY ,  ADEKA CORPORATION ,  KM Biologics Co., Ltd.

Inventor： Junichi MATSUDA ,  Sumika MIYABASHIRA ,  Satomi HARANO ,  Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Tetsuya HIGAMI ,  Seiichi FUNAMOTO ,  Ken-Ichiro HIWATARI ,  Akiko TASAKI

IPC: A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/36 ,  A61K38/48 ,  A61L27/22 ,  A61L27/26 ,  A61L27/36 ,  A61L27/54 ,  C12N5/00

CPC classification number: A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/54 ,  C12N5/0068 ,  A61L2430/00 ,  A61L2430/20 ,  A61L2430/32 ,  C12N2533/50 ,  C12N2533/56 ,  C12N2533/90

Abstract: A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

公开(公告)号：US20160051731A1

公开(公告)日：2016-02-25

申请号：US14888871

申请日：2014-05-02

Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE ,  NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY ,  SAPPORO MEDICAL UNIVERSITY ,  ADEKA CORPORATION

Inventor： Junichi MATSUDA ,  Sumika MIYABASHIRA ,  Satomi HARANO ,  Akio KISHIDA ,  Tsuyoshi KIMURA ,  Jun NEGISHI ,  Tetsuya HIGAMI ,  Seiichi FUNAMOTO ,  Ken-ichiro HIWATARI ,  Akiko TASAKI

IPC: A61L27/52 ,  A61L27/22 ,  A61L27/26 ,  C12N5/00 ,  A61L27/36

CPC classification number: A61L27/52 ,  A61K35/22 ,  A61K35/30 ,  A61K35/34 ,  A61K35/407 ,  A61K35/42 ,  A61K38/363 ,  A61K38/4833 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/3695 ,  A61L27/54 ,  A61L2430/00 ,  A61L2430/20 ,  A61L2430/32 ,  C12N5/0068 ,  C12N2533/50 ,  C12N2533/56 ,  C12N2533/90

Abstract: A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.

Abstract translation: 一种混合凝胶，其包含颗粒脱细胞组织（通过粉碎去细胞化的（来自脱细胞的生物组织）的动物衍生的生物组织），纤维蛋白原和凝血酶获得; 包含所述杂交凝胶的细胞培养物质; 制备混合凝胶的方法; 并提供了包含颗粒脱细胞组织和生物组织粘合剂的试剂盒。 本发明的混合凝胶发挥促进干细胞分化和增殖功能的效果以及对各种疾病的治疗效果。