公开(公告)号：US20180028722A1

公开(公告)日：2018-02-01

申请号：US15552669

申请日：2016-02-19

Applicant: ADEKA CORPORATION

Inventor： Jun NEGISHI ,  Ken-ichiro HIWATARI ,  Kyohei OCHIAI

IPC: A61L27/36

CPC classification number: A61L27/3691 ,  A61K35/12 ,  A61L27/3683 ,  A61L27/3687 ,  A61L2400/18 ,  A61L2430/40

Abstract: The present invention addresses the problem of providing a decellularized tissue having excellent cell adhesion properties. Provided is a decellularized tissue prepared by decellularizing a biological tissue, said decellularized tissue being characterized in that the ratio of endothermic energy amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization is 0.70 or greater when measured by differential scanning calorimetry. The ratio by mass of DNA amount, in terms of dry mass, of the decellularized tissue to the biological tissue before the decellularization may be 0.300 or smaller.

公开(公告)号：US20180016366A1

公开(公告)日：2018-01-18

申请号：US15547840

申请日：2016-02-23

Applicant: JOSHO GAKUEN EDUCATIONAL FOUNDATION ,  ADEKA CORPORATION

Inventor： Shinji SAKUMA ,  Kohta MOHRI ,  Ken-ichiro HIWATARI ,  Kyohei OCHIAI

IPC: C08F8/30 ,  C07K5/062 ,  A61K47/32

CPC classification number: C08F8/30 ,  A61K47/32 ,  C07K2/00 ,  C07K5/06026 ,  C08F220/06 ,  C08F220/56 ,  C08F226/02 ,  C08G81/00 ,  C08F2220/603

Abstract: A polymer compound has a group represented by Formula (1) or Formula (2) in a side chain. (In Formula (1), X1 represents a neutral amino acid residue or an ω-aminoalkanoic acid residue, X2 represents a membrane-permeable peptide residue, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, and a represents a number of from 1 to 50.) (In Formula (2), X4 represents a neutral amino acid residue or an ω-aminoalkanoic acid residue, X5 represents a membrane-permeable peptide residue, X6 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a benzyl group, an acyl group having 1 to 6 carbon atoms, an arylsulfonyl group, or a carboxyl group, and b represents a number of from 1 to 50.)

公开(公告)号：US20200222589A1

公开(公告)日：2020-07-16

申请号：US16615177

申请日：2018-05-25

Applicant: ADEKA CORPORATION

Inventor： Tetsuya HIGAMI ,  Kenichiro HIWATARI ,  Yu YAMAGUCHI ,  Haruki OBARA ,  Takuya KIMURA ,  Mitsumasa HOMMA ,  Kyohei OCHIAI ,  Keita KINOSHITA ,  Naoki MORIMOTO

IPC: A61L27/36 ,  A61L27/50

Abstract: A method of producing a decellularized transplantation material, wherein the method includes the steps of (a) harvesting a branch-bearing blood vessel from a vertebrate animal (a donor); (b) decellularizing the blood vessel; and (c) adhering, by a protein denaturation treatment, a portion where a branch has been excised to close the vessel. Also, a graft composition consisting of a biocompatible material that contains the decellularized transplantation material.

公开(公告)号：US20180044381A1

公开(公告)日：2018-02-15

申请号：US15547595

申请日：2016-02-23

Applicant: JOSHO GAKUEN EDUCATIONAL FOUNDATION ,  ADEKA CORPORATION

Inventor： Shinji SAKUMA ,  Kohta MOHRI ,  Ken-ichiro HIWATARI ,  Kyohei OCHIAI

IPC: C07K9/00 ,  A61K47/36 ,  A61K47/42

Abstract: A polysaccharide derivative has a partial structure represented by Formula (1) below. It is preferable that at least one of the amino acids that constitute X2 in Formula (1) below is a basic amino acid. (In the formula, X1 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a neutral amino acid or an ω-aminoalkanoic acid, X2 represents a residue obtained by removing the terminal amino group and the terminal carboxyl group from a membrane-permeable peptide, X3 represents a hydroxyl group, an amino group, an alkoxyl group having 1 to 4 carbon atoms, or a benzyloxy group, a represents a number of 0 or 1, and b represents a number of from 0 to 50.)