公开(公告)号：EP0813526A1

公开(公告)日：1997-12-29

申请号：EP96905803

申请日：1996-02-27

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH ,  SCHROEDER JUERGEN

IPC: C07D231/12 ,  C07D521/00

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: A process is disclosed for preparing N-substituted pyrazoles having the general formula (I), in which R1 stands for C¿1? to C12 alkyl or C7 to C20 phenylalkyl, and R?2, R3, R4¿ represent independently from each other hydrogen, C¿1? to C12 alkyl, C7 to C20 phenylalkyl or optionally substituted aryl residues, by reacting pyrazoles having the general formula (II), in which R?2, R3 and R4¿ have above-said meanings, with an alcohol having the general formula (III) R1-O-H, in which R1 has above-said meanings, at temperatures from 50 to 400 °C in the presence of a catalyst. The reaction of pyrazole (II) with compound (III) is carried out in a molar ratio from 0.001:1 to 1:1 in the liquid phase at a slight negative pressure up to an overpressure of 250 bars. Acids, their alkyl esters and/or their anhydrides are used as catalysts in a molar ratio from 0.0001:1 to 0.5:1 in relation to pyrazole (II).

公开(公告)号：FI120395B

公开(公告)日：2009-10-15

申请号：FI973592

申请日：1997-09-03

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH ,  SCHROEDER JUERGEN

IPC: C07D231/12 ,  C07D521/00

Abstract: PCT No. PCT/EP96/00790 Sec. 371 Date Aug. 20, 1997 Sec. 102(e) Date Aug. 20, 1997 PCT Filed Feb. 27, 1996 PCT Pub. No. WO96/27589 PCT Pub. Date Sep. 12, 1996A process for the preparation of an N-alkyl- or N-phenylalkyl-substituted pyrazole I by reacting the corresponding N-unsubstituted pyrazole II with an alcohol III of the formula R1-OH where R1 is the same alkyl or phenylalkyl group to be added to the unsubstituted nitrogen group -NH- of the pyrazole reactant. Both of the reactants, i.e. the pyrazole II and alcohol III compounds, are catalytically reacted in the liquid phase in a molar ratio of from 0.001:1 to 1:1, at temperatures of 50 DEG -400 DEG C. and under a subatmosheric pressure of from 0.8 bar up to a superatmospheric pressure of 250 bar. The catalyst required for this liquid phase reaction is selected as being at least one or more non-heterogeneous acid catalysts, their alkyl esters or their acid anhydrides.

公开(公告)号：SK286901B6

公开(公告)日：2009-07-06

申请号：SK13172001

申请日：2000-03-30

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  HERBIG KLAUS ,  FRETSCHNER ERICH ,  FROHLICH HELMUT

IPC: C07D237/00 ,  C07D237/22

Abstract: The invention relates to a method for producing 4-amino-5-chloro-1-phenyl pyridazinone-(6) by reacting 4,5-dichloro-1-phenyl pyridazinone-(6) with aqueous ammonia in the presence of a catalyst. According to the invention, a catalyst is used which is soluble in the aqueous alkaline reaction medium but which is, however, essentially insoluble in the reaction mixture that is acidically regulated after the 4-amino-5-chloro-1-phenyl pyridazinone-(6) has been removed. The inventive method makes it possible, in a simple manner, to recover and reuse the catalyst.

公开(公告)号：CZ297590B6

公开(公告)日：2007-02-07

申请号：CZ461499

申请日：1998-06-22

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/12 ,  C07D20060101 ,  C07D231/10

Abstract: Zpusob prípravy derivátu pyrazolu obecného vzorceI, kde znamená R.sup.1.n. a R.sup.2 .n.na sobe nezávisle atom vodíku, poprípade substituovanou skupinu alkylovou, cykloalkylovou, arylovou nebo aralkylovou, pri kterém se nechává reagovat karbonylovásloucenina obecného vzorce II, kde R.sup.1.n. a R.sup.2.n. mají shora uvedený význam, s hydrazinem,s hydrazinhydrátem nebo s jeho adicní solí s kyselinou ve 30 az 100 % hmotn. kyseline sírové v prítomnosti katalytického mnozství jodu nebo slouceniny, která uvolnuje jod nebo jodovodík.

公开(公告)号：AT346846T

公开(公告)日：2006-12-15

申请号：AT98942624

申请日：1998-07-25

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  WOERZ OTTO ,  FRETSCHNER ERICH ,  HANSEN HANSPETER ,  MUELLER ALBRECHT ,  BENZ KURT

IPC: C07D285/24 ,  C07D285/16

Abstract: A process for preparing 3-isopropyl-1H-2,1,3-benzothiadiazin-4 (3H)-one 2,2-dioxide (I) or a salt of Iwhich comprises reacting anthranilic isopropylamide IIsimultaneously with sulfur trioxide or chlorosulfonic acid in the presence of an organic base or with adducts of sulfur trioxide and organic basesandphosphorus oxychloride at from 50° C. to the reflux temperature, followed, if appropriate, by conversion into its salts, is described.

公开(公告)号：CA2208538C

公开(公告)日：2006-03-14

申请号：CA2208538

申请日：1995-12-13

Applicant: BASF AG

Inventor： VAN GASTEL ANNE ,  FRETSCHNER ERICH ,  BRENNER KARL SIEGFRIED ,  MERKLE HANS RUPERT ,  SCHONHERR MICHAEL

IPC: C07C59/70 ,  A01N39/02 ,  A01N39/04 ,  C07C51/41

Abstract: A process is disclosed for preparing solid, free-flowing water-soluble salts of aryloxy-C1-C4-alkane carboxylic acids. Aryloxy-C1-C4-alkane carboxylic acids are reacted with a salt-forming base. Salts are formed in t he melt in the presence or absence of an entrainer suitable for causing azeotropic water separation or in a solution in the presence of an entrainer suitable for causing azeotropic water separation. The entrainer is removed from the reaction mixture during or after the reaction and the solid salts are then isolated in the usual manner.

公开(公告)号：DE59611302D1

公开(公告)日：2005-12-29

申请号：DE59611302

申请日：1996-01-04

Applicant: BASF AG

Inventor： MERKLE RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/12

Abstract: PCT No. PCT/EP96/00011 Sec. 371 Date Jul. 3, 1997 Sec. 102(e) Date Jul. 3, 1997 PCT Filed Jan. 4, 1996 PCT Pub. No. WO96/21650 PCT Pub. Date Jul. 18, 1996A process for preparing 3,5-diarylpyrazoles of the general formula I I where the substituents have the following meanings: R1 and R3 are unsubstituted or substituted aryl radicals, R2 is hydrogen, C1-C8-alkyl or unsubstituted or substituted aryl, in which hydrazine hydrate is reacted with a 1,3-diarylpropenone of the general formula II II where the substituents R1, R2 and R3 have the abovementioned meanings, in sulfuric acid in the presence of iodine or an iodine compound, is described.

公开(公告)号：DE59811432D1

公开(公告)日：2004-06-24

申请号：DE59811432

申请日：1998-06-22

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH

IPC: C07D231/12 ,  C07D20060101 ,  C07D231/10

Abstract: Pyrazole derivatives are prepared by reacting carbonyl compounds R1-C(O)-CH(R2)-CH2R3 with hydrazine, its hydrate or its salts in 30 to 100% by weight sulfuric acid in the presence of catalytic amounts of iodine or of an iodine compound.

公开(公告)号：SK13172001A3

公开(公告)日：2002-05-09

申请号：SK13172001

申请日：2000-03-30

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  HERBIG KLAUS ,  FRETSCHNER ERICH ,  FROHLICH HELMUT

IPC: C07D237/22

Abstract: In a process for preparing 4-amino-5-chloro-1-phenylpyridazin-6-one by reacting 4,5-dichloro-1-phenylpyridazin-6-one with aqueous ammonia in the presence of a catalyst, the catalyst used is soluble in the aqueous alkaline reaction medium but is essentially insoluble in the reaction medium which has been acidified after removal of the 4-amino-5-chloro-1-phenylpyridazin-6-one.The process of the present invention makes it possible for the catalyst to be recovered and reused in a simple manner.

公开(公告)号：AU1702601A

公开(公告)日：2001-05-30

申请号：AU1702601

申请日：2000-11-17

Applicant: BASF AG

Inventor： MERKLE HANS RUPERT ,  FRETSCHNER ERICH ,  KOOB KNUT

IPC: C07D231/20 ,  C07D231/22