公开(公告)号：JP2000314703A

公开(公告)日：2000-11-14

申请号：JP2000050820

申请日：2000-02-28

Applicant: BASF AG

Inventor： SCHROFF WOLFGANG ,  KLINGLER JUERGEN DR ,  HORN DIETER DR

IPC: G01J3/28 ,  G01J3/44 ,  G01J3/457 ,  G01N21/65

Abstract: PROBLEM TO BE SOLVED: To quickly measure bonding of an active compound to a substrate of substance with high accuracy by measuring the transition of a reference active compound from a bonded state to the substrate in a sample to a free diffused state by a Raman correlation spectrometry. SOLUTION: The transition of at least one kind of reference active compound in a sample from a bonded state to a substrate disposed in the sample, to a free diffused state is measured by a Raman correlation spectrometry, that is, a laser 3 is coupled in the form of converging on extremely small volume in the sample by an image focusing optical system of a microscope 1. Obtained Raman light is optically separated from laser beams by a filter 5. A diffraction grating spectrometer 8 of high light transmittance spectrally separates Raman light, and an optical image focusing system 9 guarantees detection in a high sensitive detector 10 of a selected Raman band. An electric signal from the detector 10 is sent to a collimator 11 and signal-processed to determine the autocorrelation function.