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    SEARCH FOR ACTIVE COMPOUND AND EQUIPMENT USED THEREFOR
    2.
    发明专利
    SEARCH FOR ACTIVE COMPOUND AND EQUIPMENT USED THEREFOR 失效

    公开(公告)号：JP2000314703A

    公开(公告)日：2000-11-14

    申请号：JP2000050820

    申请日：2000-02-28

    Applicant: BASF AG

    Inventor： SCHROFF WOLFGANG ,  KLINGLER JUERGEN DR ,  HORN DIETER DR

    IPC: G01J3/28 ,  G01J3/44 ,  G01J3/457 ,  G01N21/65

    Abstract: PROBLEM TO BE SOLVED: To quickly measure bonding of an active compound to a substrate of substance with high accuracy by measuring the transition of a reference active compound from a bonded state to the substrate in a sample to a free diffused state by a Raman correlation spectrometry. SOLUTION: The transition of at least one kind of reference active compound in a sample from a bonded state to a substrate disposed in the sample, to a free diffused state is measured by a Raman correlation spectrometry, that is, a laser 3 is coupled in the form of converging on extremely small volume in the sample by an image focusing optical system of a microscope 1. Obtained Raman light is optically separated from laser beams by a filter 5. A diffraction grating spectrometer 8 of high light transmittance spectrally separates Raman light, and an optical image focusing system 9 guarantees detection in a high sensitive detector 10 of a selected Raman band. An electric signal from the detector 10 is sent to a collimator 11 and signal-processed to determine the autocorrelation function.

    METHOD AND APPARATUS FOR PRODUCING STABLE FINE PARTICLE
    4.
    发明专利
    METHOD AND APPARATUS FOR PRODUCING STABLE FINE PARTICLE 失效

    公开(公告)号：JP2000225333A

    公开(公告)日：2000-08-15

    申请号：JP37697699

    申请日：1999-12-22

    Applicant: BASF AG

    Inventor： LOCKEMANN CHRISTIAN ,  LUEDDECKE ERIK ,  HORN DIETER DR

    IPC: A61J3/02 ,  B01J2/00 ,  B01J2/04 ,  B01J3/00 ,  B01J13/06 ,  B01J19/00

    Abstract: PROBLEM TO BE SOLVED: To eliminate the generation of aggregation, precipitation, and diffusion and to produce stable fine particles efficiently by dissolving two kinds of substances in different compressible supercritical fluids, making the substances penetrate into each other in conditions in which the dissolution limit of one substance exceeds earlier than that of the other substance. SOLUTION: When substances A, B are dissolved in a supercritical fluid, and the pressure of the solution is reduced along a pressure holding section to produce stable fine particles, the substances A, B are dissolved in different compressible supercritical fluids. In conditions in which the dissolution limit of the substance A exceeds earlier than that of the substance B, the substances are made to penetrate into each other. For example, fluids are passed from both supply lines 1, 5 through both high pressure autoclaves 2, 6, where the substances A, B are taken out. Both supply lines 3, 7 are connected to both pressure reducing apparatuses 4, 8, and the mixing of the fluids before pressure reduction is prevented. Moreover, the particles 10 of the substance A are coated with the substance B.

    RAMAN CORRELATION SPECTROSCOPIC ANALYSIS METHOD AND ANALYZER THEREFOR
    5.
    发明专利
    RAMAN CORRELATION SPECTROSCOPIC ANALYSIS METHOD AND ANALYZER THEREFOR 失效

    公开(公告)号：JPH1096698A

    公开(公告)日：1998-04-14

    申请号：JP20305097

    申请日：1997-07-29

    Applicant: BASF AG

    Inventor： SCHROF WOLFGANG DR ,  KLINGLER JUERGEN DR ,  HORN DIETER DR

    IPC: G01N21/65 ,  G01J3/28 ,  G01J3/44 ,  G01J3/457 ,  G01N15/02

    Abstract: PROBLEM TO BE SOLVED: To provide a method with good selectivity for measuring a diffusion parameter of particles, e.g. a diffusion speed, a diffusion coefficient, local concentration, size and the flow behavior of particles, which eliminates marking to particles to be observed. SOLUTION: An excitation light of a light source, particularly a laser is directed to a sample 10, and a Raman scattering light from the observed capacity sample is collected and guided to a spectrometer, particularly a grating spectrograph 6. The light is developed to spectral lines. A luminance of at least one spectral line is measured at least ten times for every second by a photodetector 8, particularly a photoelectric multiplier or a photodiode. Based on the measured luminance value of the spectral line, a diffusion parameter, concentration, size or the flow behavior of particles in the sample corresponding to the spectral line is calculated by analyzing a change in luminance value, particularly a self correlation or a frequency.

    8.
    发明专利
    未知

    公开(公告)号：DE19630956A1

    公开(公告)日：1998-02-05

    申请号：DE19630956

    申请日：1996-07-31

    Applicant: BASF AG

    Inventor： SCHROF WOLFGANG DR ,  KLINGLER JUERGEN DR ,  HORN DIETER DR

    IPC: G01N21/65 ,  G01J3/28 ,  G01J3/44 ,  G01J3/457 ,  G01N15/02 ,  G01J3/453

    Abstract: The method uses a laser light source (1) for illuminating the sample (10), with detection of the Raman dispersed light and division into its spectral lines via a grid spectrograph (6). The intensity of at least one spectral line is measured at least 10 times per second using a photodetector (8), with fluctuation analysis, autocorrelation, or frequency analysis of the measured intensity values.

    9.
    发明专利
    未知

    公开(公告)号：ES2066306T3

    公开(公告)日：1995-03-01

    申请号：ES91116027

    申请日：1991-09-20

    Applicant: BASF AG

    Inventor： END LUTZ DR ,  HORN DIETER DR ,  LUEDDECKE ERIK DR ,  SCHNEIDER JOACHIM U DR ,  HOPPE PETER PAUL DR ,  RENSMANN FRIEDRICH-WILHELM DR

    IPC: A61K9/00 ,  A61K9/107 ,  A61K9/08 ,  A61K31/015 ,  A61K31/07 ,  A61K47/14 ,  A61P15/00 ,  C07B63/04 ,  C07C403/24 ,  C09K23/00

    Abstract: Method for the continuous preparation of beta -carotene solubilisates by brief heating of beta -carotene together with an emulsifier until solution takes place, rapid cooling of the homogeneous solution to below 100 DEG C by addition of water and subsequent adjustment of the required final concentrations of beta -carotene, which is characterised in that a suspension, which has been preheated to 20 to 80 DEG C, of 1 to 40% by weight beta -carotene in an emulsifier is pumped through a heating coil located in a heat-transfer oil, where the temperature in the solubilisation mixture is 120 to 180 DEG C and the residence time is 10 to 300 seconds, and the homogeneous solution is turbulently mixed in a mixing chamber with such quantities of water at 10 to 80 DEG C that a solubilisate containing 0.5 to 6% by weight beta -carotene is produced and is, where appropriate, further diluted to the required final concentration.

    10.
    发明专利
    未知

    公开(公告)号：DE3784534D1

    公开(公告)日：1993-04-15

    申请号：DE3784534

    申请日：1987-03-27

    Applicant: BASF AG

    Inventor： HORN DIETER DR ,  QUADBECK-SEEGER HANS-JUERGEN P ,  SCHAEFER PETER DR ,  HAEHNLEIN WOLFGANG DR

    IPC: A23L5/44 ,  B01J13/02 ,  C09B61/00 ,  C09B67/02 ,  C09B67/42

    Abstract: Prepn. of finely divided,powdery carotenoid compsns., in which the particle size of the carotenoid is less than 0.5 microns, involves (a) dissolving a carotenoid in a volatile, water-miscible organic solvent at 50-240 deg. C, opt. under increased pressure, within less than 10 secs., (b) immediate pptn. of the carotenoid in colloidal dispersed form, from the molecular dispersed soln., by rapid mixing, at 0-50 deg. C, with milk, skimmed milk, or an aq. soln. of dried milk, as a colloid, and (c) freeing the dispersion from solvent and dispersant. The solvent is an alcohol, ketone, ester, acetal or ether, partic. acetone, 1,2-butane diol-1-methyl ether, 1,2-propane diol 1-n-propyl ether, ethanol, n- or iso-propanol or mixts. Prepn. of the molecular dispersed soln., and pptn. of the carotenoid, are pref. carried out continuously in 2 mixers connected in series.

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