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公开(公告)号:JP2000189064A
公开(公告)日:2000-07-11
申请号:JP25061799
申请日:1999-09-03
Applicant: BASF AG
Inventor: FRIEDRICH THOMAS DR , BEWERT WOLFGANG DR , LUEDDECKE ERIK DR , KLINGLER JUERGEN DR , HEGER ROBERT DR
IPC: A23B5/00 , A23J3/00 , A23J3/04 , A23J3/06 , A23J3/10 , A23J3/16 , A23J3/18 , A23K1/00 , A23K1/16 , A23K1/165 , A23L1/00 , A23L33/15 , A23P1/04 , A61K9/16 , A61K38/00 , C12N9/06
Abstract: PROBLEM TO BE SOLVED: To obtain an active component compound that is convenient, economic and applicable over a wide range, has excellent sustained release properties, efficacy persistency, and is useful in medicinal compositions, foods, feeds for animals, and the like by surrounding active components with a coating layer made of a protein crosslinked with a specific enzyme. SOLUTION: One or more kinds of vitamins, enzymes, additives for foods, additives for feeds and other active components are surrounded with a part of a coating layer made of a protein crosslinked with one or more kinds of enzymes selected from lipoxygenase, protein disulfide isomerase, phenol oxidase, phenol peroxidase, lysyl oxidase, protein disulfide reductase, tyrosine oxidase, or sulfhydryl oxidase to give an active component compound. It is preferable that the mass ratio of the active components to the protein is in the range of from 1/100 to 5/1 and the active ingredients are hydrophobic.
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公开(公告)号:JPH1096698A
公开(公告)日:1998-04-14
申请号:JP20305097
申请日:1997-07-29
Applicant: BASF AG
Inventor: SCHROF WOLFGANG DR , KLINGLER JUERGEN DR , HORN DIETER DR
Abstract: PROBLEM TO BE SOLVED: To provide a method with good selectivity for measuring a diffusion parameter of particles, e.g. a diffusion speed, a diffusion coefficient, local concentration, size and the flow behavior of particles, which eliminates marking to particles to be observed. SOLUTION: An excitation light of a light source, particularly a laser is directed to a sample 10, and a Raman scattering light from the observed capacity sample is collected and guided to a spectrometer, particularly a grating spectrograph 6. The light is developed to spectral lines. A luminance of at least one spectral line is measured at least ten times for every second by a photodetector 8, particularly a photoelectric multiplier or a photodiode. Based on the measured luminance value of the spectral line, a diffusion parameter, concentration, size or the flow behavior of particles in the sample corresponding to the spectral line is calculated by analyzing a change in luminance value, particularly a self correlation or a frequency.
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公开(公告)号:JP2000314703A
公开(公告)日:2000-11-14
申请号:JP2000050820
申请日:2000-02-28
Applicant: BASF AG
Inventor: SCHROFF WOLFGANG , KLINGLER JUERGEN DR , HORN DIETER DR
Abstract: PROBLEM TO BE SOLVED: To quickly measure bonding of an active compound to a substrate of substance with high accuracy by measuring the transition of a reference active compound from a bonded state to the substrate in a sample to a free diffused state by a Raman correlation spectrometry. SOLUTION: The transition of at least one kind of reference active compound in a sample from a bonded state to a substrate disposed in the sample, to a free diffused state is measured by a Raman correlation spectrometry, that is, a laser 3 is coupled in the form of converging on extremely small volume in the sample by an image focusing optical system of a microscope 1. Obtained Raman light is optically separated from laser beams by a filter 5. A diffraction grating spectrometer 8 of high light transmittance spectrally separates Raman light, and an optical image focusing system 9 guarantees detection in a high sensitive detector 10 of a selected Raman band. An electric signal from the detector 10 is sent to a collimator 11 and signal-processed to determine the autocorrelation function.
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公开(公告)号:JPH1183464A
公开(公告)日:1999-03-26
申请号:JP16069198
申请日:1998-06-09
Applicant: BASF AG
Inventor: SCHROF WOLFGANG DR , RUNGE FRANK DR , KLINGLER JUERGEN DR
Abstract: PROBLEM TO BE SOLVED: To observe dynamic interface development by generating droplet flow containing a first liquid phase, moving the droplets in a specified track, and measuring the coverage of the interface coated with at least one of molecular species at a plurality of points in the track in non-contact manner. SOLUTION: A dropletor 1 generates and releases uniform droplets 2 at regular intervals. The liquid drops 2 move along a droplet trajectory shown by an arrow 3. A laser 4 radiates laser beam to the droplets in the track through a semisilvered mirror 5 and a lens 6. The light rays reflected by the droplets 2, especially the surface of the molecules, enter a detector 7 through the lens 6 and the semi-transparent mirror 5. The detector 7 enables the droplets to move in the track in the direction shown by an arrow 8 to observe the droplets 2 having the coverage in different generation steps. The detection signals are analyzed by an analysis unit. By this method, the interfacial adsorption of a substance can quickly and continuously be measured in non-contact manner.
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公开(公告)号:DE19630956A1
公开(公告)日:1998-02-05
申请号:DE19630956
申请日:1996-07-31
Applicant: BASF AG
Inventor: SCHROF WOLFGANG DR , KLINGLER JUERGEN DR , HORN DIETER DR
Abstract: The method uses a laser light source (1) for illuminating the sample (10), with detection of the Raman dispersed light and division into its spectral lines via a grid spectrograph (6). The intensity of at least one spectral line is measured at least 10 times per second using a photodetector (8), with fluctuation analysis, autocorrelation, or frequency analysis of the measured intensity values.
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公开(公告)号:DE19724238A1
公开(公告)日:1998-12-10
申请号:DE19724238
申请日:1997-06-09
Applicant: BASF AG
Inventor: SCHROF WOLFGANG DR , RUNGE FRANK DR , KLINGLER JUERGEN DR
Abstract: Determination of the deposition of at least one type of molecule at the boundary layer between two liquid phases or a liquid and a gaseous phase. A stream of droplets is generated and directed along a path and the measurement is then made without contact at at least two positions on the drop path. Also claimed is the equipment required for this method.
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公开(公告)号:DE4429239A1
公开(公告)日:1996-02-22
申请号:DE4429239
申请日:1994-08-18
Applicant: BASF AG
Inventor: FRIEDRICH THOMAS DR , HORN DIETER DR , KLINGLER JUERGEN DR , WIESE HARM DR
Abstract: The spectroscopy method involves feeding light from a stimulation light source (1) via a first optical fibre (2) to a fibre coupler (3) and from there via a second optical fibre (4) to a specimen (6). Fluorescent light emitted from particles in the specimen are fed via the second optical fibre back to the coupler and from there via a third optical fibre (8) to a detector (10). Alternatively, the light from the source can be fed to the specimen via a first optical fibre and fluorescent light from particles in the specimen passed via a second fibre to a detector, whereby the ends of the fibres facing the specimen are oriented w.r.t. each other so that emitted stimulation light passes to a specimen region from which fluorescent light will be detected.
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公开(公告)号:AT235674T
公开(公告)日:2003-04-15
申请号:AT97113097
申请日:1997-07-30
Applicant: BASF AG
Inventor: SCHROF WOLFGANG DR , KLINGLER JUERGEN DR , HORN DIETER DR
Abstract: The method uses a laser light source (1) for illuminating the sample (10), with detection of the Raman dispersed light and division into its spectral lines via a grid spectrograph (6). The intensity of at least one spectral line is measured at least 10 times per second using a photodetector (8), with fluctuation analysis, autocorrelation, or frequency analysis of the measured intensity values.
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公开(公告)号:DE19533092A1
公开(公告)日:1997-03-13
申请号:DE19533092
申请日:1995-09-07
Applicant: BASF AG
Inventor: SCHROF WOLFGANG DR , KLINGLER JUERGEN DR , HORN DIETER DR , MAYER ELMAR DR
IPC: G01N21/64 , G01N33/533
Abstract: Assembly applies a laser-induced two-photon fluorescence correlation spectroscopy (TPA-FCS) process to a sample. The novelty is that a number of volumes (6) are defined within the assembly, into which samples (3) are introduced and which are agitated by a single laser (1) and simultaneously observed. Also claimed is that the laser beam (1) is modified to incorporate several focus ranges, esp. ≥ 1 of
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