公开(公告)号：CA2138287C

公开(公告)日：2005-03-01

申请号：CA2138287

申请日：1993-06-08

Applicant: BASF AG

Inventor： STEINER GERD ,  UNGER LILIANE ,  BEHL BERTHOLD ,  TESCHENDORF HANS-JUERGEN

IPC: C07D401/04 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/445 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  A61P43/00 ,  C07D209/52 ,  C07D409/04 ,  A61K31/44 ,  C07D403/04

Abstract: Compounds of the formula I: (See formula I) in which the substituents have the meanings stated in the description, and their preparation are described. These novel compounds are suitable as neuroleptics, antidepressants, sedatives, hypnotics, CNS protectives or muscle relaxants.

公开(公告)号：DE59510596D1

公开(公告)日：2003-04-24

申请号：DE59510596

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MUELLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: C07D277/22 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/496 ,  A61K31/54 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12

Abstract: PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.

公开(公告)号：SI1025100T1

公开(公告)日：2002-10-31

申请号：SI9830101

申请日：1998-10-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: C07D471/00

公开(公告)号：PT994865E

公开(公告)日：2002-08-30

申请号：PT98938687

申请日：1998-07-03

Applicant: BASF AG

Inventor： UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  TREIBER HANS-JORG ,  WICKE KARSTEN ,  STARCK DOROTHEA ,  BLANK STEFAN ,  NEUMANN-SCHULTZ BARBARA ,  BRIS THEOPHILE-MARIE LE

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/506 ,  A61K31/53 ,  A61K31/551 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/08 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.

公开(公告)号：DK0772603T3

公开(公告)日：2002-07-15

申请号：DK95926898

申请日：1995-07-14

Applicant: BASF AG

Inventor： UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  BIALOJAN SIEGFRIED ,  HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D401/00 ,  C07D401/12

Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：AT219063T

公开(公告)日：2002-06-15

申请号：AT95926898

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D401/00 ,  C07D401/12

Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：NO312243B1

公开(公告)日：2002-04-15

申请号：NO970473

申请日：1997-02-03

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  HOEGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN

IPC: C07D401/06 ,  A61K31/40 ,  A61K31/415 ,  A61K31/47 ,  A61K31/505 ,  A61P25/18 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D513/04 ,  A61K31/506

Abstract: PCT No. PCT/EP95/02893 Sec. 371 Date Sep. 18, 1997 Sec. 102(e) Date Sep. 18, 1997 PCT Filed Jul. 21, 1995 PCT Pub. No. WO96/04272 PCT Pub. Date Feb. 15, 1996N-substitued 3-azabicyclo[3.2.0]heptane derivatives of formula (I) in which R1, R2, A, X, Y and Z have the meanings given in the description, their method of preparation and their use as pharmacological agents.

公开(公告)号：BG63500B1

公开(公告)日：2002-03-29

申请号：BG10111397

申请日：1997-01-06

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D249/12 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: The invention relates to triazole compounds with the formula where R1 & R2 mean hydrogen or different substituents, A is a two-valent group, B is residue with formula a, b or c and Ar in a given case means substituted phenyl, pyridyl, pyrimidyl or triazinyl. The compounds have higher affinity to dopamine-D3-receptors and can be used for the treatment of diseases which react to dopamine-D3-ligands. 13 claims

公开(公告)号：DE59802922D1

公开(公告)日：2002-03-14

申请号：DE59802922

申请日：1998-10-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: 3-substituted tetrahydropyridopyrimidinone derivatives of the formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives and, to their use for producing active ingredients for drugs.

公开(公告)号：ZA200101976B

公开(公告)日：2002-03-11

申请号：ZA200101976

申请日：2001-03-09

Applicant: BASF AG

Inventor： STEINER GERD ,  HOEGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  JUCHELKA FRIEDER

IPC: A61K31/425 ,  A61K31/428 ,  A61P25/00 ,  C07D417/06 ,  C07D ,  A61K

Abstract: Compounds of the formula I:in which R1, R2, R3 and R4 have the meanings stated in the description, are described.The novel compounds are suitable for controlling diseases.