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公开(公告)号：AU749575B2
公开(公告)日：2002-06-27
申请号：AU9342698
申请日：1998-08-14
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JORG , KOSER STEFAN , SCHAFER BERND , THYES MARCO , HOGER THOMAS
IPC: C07D239/56 , A61K20060101 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14
Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.
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公开(公告)号：SI0994865T1
公开(公告)日：2002-04-30
申请号：SI9830098
申请日：1998-07-03
Applicant: BASF AG
Inventor： STARCK DOROTHEA , BLANK STEFAN , TREIBER HANS-JOERG , UNGER LILIANE , NEUMANN-SCHULTZ BARBARA , LE BRIS THEOPHILE-MARIE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.
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公开(公告)号：TR200000406T2
公开(公告)日：2000-05-22
申请号：TR200000406
申请日：1998-08-14
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JORG , KOSER STEFAN , SCHAFER BERND , THYES MARCO , HOEGER THOMAS
IPC: A61K20060101 , C07D239/56 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14
Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.
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公开(公告)号：NO20000665D0
公开(公告)日：2000-02-10
申请号：NO20000665
申请日：2000-02-10
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JOERG , KOSER STEFAN , SCHOFER BERND , THYES MARCO , HOEGER THOMAS
IPC: A61K20060101 , C07D239/56 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14 , C07D
Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.
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公开(公告)号：NO20000665A
公开(公告)日：2000-02-10
申请号：NO20000665
申请日：2000-02-10
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JOERG , KOSER STEFAN , SCHOFER BERND , THYES MARCO , HOEGER THOMAS
IPC: C07D239/56 , A61K20060101 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14
CPC classification number: C07D239/56
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Patent Agency Ranking
公开(公告)号：BG102616A
公开(公告)日：1999-04-30
申请号：BG10261698
申请日：1998-07-09
Applicant: BASF AG
Inventor： TREIBER HANS-JOERG , BLANK STEFAN , STARCK DOROTHEA , UNGER LILIANE , TESCHEDORF HANS-JUERGEN , WICKE KARSTEN
IPC: C07D243/08 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/18 , A61P43/00 , C07D213/73 , C07D223/04 , C07D245/02 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
Abstract: The compounds have affinity to dopamin-D3-receptors and canbe used for the treatment of diseases caused bydopamin-D3-ligands. Aza- and diazacycloheptane and cyclooctanederivatives have the formulaAr1 - A - B - Ar2where Ar1, A, B & Ar2 have the meanings listed in the description16 claims
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公开(公告)号：CA2296102A1
公开(公告)日：1999-01-21
申请号：CA2296102
申请日：1998-07-03
Applicant: BASF AG
Inventor： NEUMANN-SCHULTZ BARBARA , BLANK STEFAN , TESCHENDORF HANS-JUERGEN , TREIBER HANS-JOERG , STARCK DOROTHEA , LE BRIS THEOPHILE-MARIE , WICKE KARSTEN , UNGER LILIANE
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to triazole compounds of formula (I), wherein Ar1, A, B and Ar2 have the meanings cited in the description. The inventive compounds exhibit high dopamine-D3-receptor affinity and can thus be used in the treatment of diseases responding to dopamine-D3-ligands.
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公开(公告)号：DE19600934A1
公开(公告)日：1997-07-17
申请号：DE19600934
申请日：1996-01-12
Applicant: BASF AG
Inventor： TREIBER HANS-JOERG , BLANK STEFAN , STARCK DOROTHEA , UNGER LILIANE , TESCHEDORF HANS-JUERGEN , WICKE KARSTEN
IPC: C07D243/08 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/18 , A61P43/00 , C07D213/73 , C07D223/04 , C07D245/02 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07C403/12 , C07D225/02 , C07D227/04 , C07D247/00 , C07D243/06 , A61K31/495
Abstract: The present invention concerns aza- and diazacycloheptane and cyclooctane compounds from the following formula (I) Ar -A-B-Ar wherein Ar , A, B, and Ar have the meanings given in the description. The compounds according to the invention possess a high affinity with the dopamine-D3-receptors and can therefore be used for the treatment of illness, which react to dopamine-D3-ligands.
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公开(公告)号：CA2241787C
公开(公告)日：2006-04-04
申请号：CA2241787
申请日：1997-01-10
Applicant: BASF AG
Inventor： TESCHENDORF HANS-JURGEN , WICKE KARSTEN , TREIBER HANS-JORG , STARCK DOROTHEA , BLANK STEFAN , UNGER LILIANE
IPC: C07D243/08 , C07D403/14 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/18 , A61P43/00 , C07D213/73 , C07D223/04 , C07D245/02 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
Abstract: The present invention concerns aza- and diazacycloheptane and cyclooctane compounds from the following formula (I) Ar1-A-B-Ar2 wherein Ar1, A, B, and Ar2 have the meanings given in the description. The compounds according to the invention possess a high affinity with the dopamine-D3-receptors and can therefore be used for the treatment o f illness, which react to dopamine-D3-ligands.
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公开(公告)号：PT994865E
公开(公告)日：2002-08-30
申请号：PT98938687
申请日：1998-07-03
Applicant: BASF AG
Inventor： UNGER LILIANE , TESCHENDORF HANS-JUERGEN , TREIBER HANS-JORG , WICKE KARSTEN , STARCK DOROTHEA , BLANK STEFAN , NEUMANN-SCHULTZ BARBARA , BRIS THEOPHILE-MARIE LE
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.
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