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公开(公告)号：MY132474A
公开(公告)日：2007-10-31
申请号：MYPI19972614
申请日：1997-06-12
Applicant: BAXTER INT
Inventor： NORMA J OFSTHUN , PAUL J SOLTYS , GRETCHEN A KUNAS
Abstract: THE PRESENT INVENTION PROVIDES AN IMPROVED AFFINITY MEMBRANE DEVICE AND METHOD FOR THE EFFECTIVE REMOVAL OF TARGET MOLECULES IN PLASMA. THE AFFINITY MEMBRANE DEVICE IS DESIGNED FOR USE IN AN EXTRACORPOREAL BLOOD CIRCUIT AND CAN BE EMPLOYED CONCURENTLY WITH OTHER THERAPEUTIC PROCESSES FOR THE PURIFICATION OF BLOOD. THE DEVICE OF THE PRESENT INVENTION CONSISTS OF HOLLOW FIBER MEMBRANES HAVING SPECIFIED DIMENSIONS AND TRANSFER PROPERTIES, LIGAND IMMOBILIZED TO THE PORE SURFACE OF THE HOLLOW FIBERS AND ALLOW APPROPRIATE ENTRY AND EXIT OF THE BLOOD. IN A PREFERRED EMBODIMENT, SPECIFIC IMMOBILIZATION CHEMISTRIES ARE UTILIZED TO ATTACH THE LIGANDS TO THE HOLLOW FIBERS FOR OPTIMAL FUNCTION.
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公开(公告)号：AU729964B2
公开(公告)日：2001-02-15
申请号：AU3490497
申请日：1997-06-16
Applicant: BAXTER INT
Inventor： OFSTHUN NORMA J , SOLTYS PAUL J , GRETCHEN A KUNAS
IPC: A61M1/36 , B01D61/00 , B01D63/02 , B01D67/00 , B01D69/14 , B01J20/28 , B01J20/32 , B01D69/08 , B01D15/08
Abstract: The present invention provides an improved affinity membrane device and method for the effective removal of target molecules in plasma. The affinity membrane device is designed for use in an extracorporeal blood circuit and can be employed concurrently with other therapeutic processes for the purification of blood. The device of the present invention consists of hollow fiber membranes having specified dimensions and transfer properties, ligand immobilized to the pore surface of the hollow fibers, and a housing to encase the hollow fibers and allow appropriate entry and exit of the blood. In a preferred embodiment, specific immobilization chemistries are utilized to attach the ligands to the hollow fibers for optimal function.
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公开(公告)号：AU3490497A
公开(公告)日：1998-01-07
申请号：AU3490497
申请日：1997-06-16
Applicant: BAXTER INT
Inventor： OFSTHUN NORMA J , SOLTYS PAUL J , GRETCHEN A KUNAS
IPC: A61M1/36 , B01D61/00 , B01D63/02 , B01D67/00 , B01D69/14 , B01J20/28 , B01J20/32 , B01D69/08 , B01D15/08
Abstract: The present invention provides an improved affinity membrane device and method for the effective removal of target molecules in plasma. The affinity membrane device is designed for use in an extracorporeal blood circuit and can be employed concurrently with other therapeutic processes for the purification of blood. The device of the present invention consists of hollow fiber membranes having specified dimensions and transfer properties, ligand immobilized to the pore surface of the hollow fibers, and a housing to encase the hollow fibers and allow appropriate entry and exit of the blood. In a preferred embodiment, specific immobilization chemistries are utilized to attach the ligands to the hollow fibers for optimal function.
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公开(公告)号：AT238095T
公开(公告)日：2003-05-15
申请号：AT97931211
申请日：1997-06-16
Applicant: BAXTER INT
Inventor： OFSTHUN NORMA J , SOLTYS PAUL J , GRETCHEN A KUNAS
IPC: A61M1/36 , B01D61/00 , B01D63/02 , B01D67/00 , B01D69/14 , B01J20/28 , B01J20/32 , B01D69/08 , B01D15/08
Abstract: The present invention provides an improved affinity membrane device and method for the effective removal of target molecules in plasma. The affinity membrane device is designed for use in an extracorporeal blood circuit and can be employed concurrently with other therapeutic processes for the purification of blood. The device of the present invention consists of hollow fiber membranes having specified dimensions and transfer properties, ligand immobilized to the pore surface of the hollow fibers, and a housing to encase the hollow fibers and allow appropriate entry and exit of the blood. In a preferred embodiment, specific immobilization chemistries are utilized to attach the ligands to the hollow fibers for optimal function.
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