公开(公告)号：CA2826748C

公开(公告)日：2020-08-04

申请号：CA2826748

申请日：2012-02-09

Applicant: BIO-RAD LABORATORIES INC

Inventor： REGAN JOHN FREDERICK ,  SAXONOV SERGE ,  LUCERO MIKE ,  HINDSON BEN ,  BELGRADER PHIL ,  DUBE SIMANT ,  SO AUSTIN ,  MELLEN JEFFREY CLARK ,  HEREDIA NICHOLAS JACK ,  NESS KEVIN ,  COLSTON BILL

IPC: C12Q1/68 ,  C12Q1/6809 ,  C12Q1/683 ,  C12Q1/686 ,  C40B30/00

Abstract: Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.

公开(公告)号：EP2971160A4

公开(公告)日：2016-12-07

申请号：EP14770183

申请日：2014-03-13

Applicant: BIO-RAD LABORATORIES INC

Inventor： REGAN JOHN ,  COOPER SAMANTHA ,  SO AUSTIN ,  KOEHLER RYAN ,  MONTESCLAROS LUZ

IPC: C12Q1/68

CPC classification number: C12Q1/6858 ,  C12Q2545/114 ,  C12Q2561/101 ,  C12Q2563/159

Abstract: Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate.