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公开(公告)号：IN82DE2012A
公开(公告)日：2015-05-01
申请号：IN82DE2012
申请日：2012-01-10
Applicant: COUNCIL SCIENT IND RES
Inventor： SUNITA KHANDERAO GADAKH , REDDY SANTHOSH REKULA , ARUMUGAM SUDALAI
IPC: C12N20060101
Abstract: The invention relates to a novel process for the synthesis of HIV protease inhibitors. More particularly, the invention relates to the synthesis of HIV protease inhibitorssuch as AmprenavirFosamprenavir,Darunavir and sequinavirvia synazido epoxide with high enantiomeric excessas a common intermediateobtained by Co-catalyzed hydrolytic kinetic resolution of anti-(2SR, 3SR)-3-azido-4-phenyl-l, 2-epoxybutane.
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