公开(公告)号：WO2013072830A1

公开(公告)日：2013-05-23

申请号：PCT/IB2012056340

申请日：2012-11-12

Applicant: COUNCIL SCIENT IND RES

Inventor： REDDY REKULA SANTOSH ,  NAGA CHITHANYA KIRAN INDUKURU ,  ARUMUGAM SUDALAI

IPC: C07B53/00 ,  C07D307/88

CPC classification number: C07D307/88 ,  C07B53/00 ,  C07D307/92 ,  C07D493/04

Abstract: The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phthalides via synergetic nitrile accelerated oxidative cyclization of o-cyano substituted aryl alkenes in high yield and enantiomeric excess (ee) in short reaction time. Also, disclosed herein is "one -pot" asymmetric synthesis of biologically important natural compounds having 3-substituted chiral phthalide structural framework in the molecule.

Abstract translation: 本发明公开了用于合成3-取代的手性苯酞的单步高度对映选择性催化氧化环化方法。 特别地，本发明公开了通过在短反应时间内以高收率和对映体过量（ee）协同腈促进氧化环化邻氰基取代的芳基烯烃来手性苯酞的不对称合成。 此外，本文公开的是分子中具有3-取代的手性苯酞结构骨架的生物学上重要的天然化合物的“一锅法”不对称合成。

公开(公告)号：WO2013072830A4

公开(公告)日：2013-08-22

申请号：PCT/IB2012056340

申请日：2012-11-12

Applicant: COUNCIL SCIENT IND RES

Inventor： REDDY REKULA SANTOSH ,  NAGA CHITHANYA KIRAN INDUKURU ,  ARUMUGAM SUDALAI

IPC: C07B53/00 ,  C07D307/88

CPC classification number: C07D307/88 ,  C07B53/00 ,  C07D307/92 ,  C07D493/04

Abstract: The present invention discloses single step, highly enantioselective catalytic oxidative cyclization process for the synthesis of 3-substituted chiral phthalides. In particular, the invention discloses asymmetric synthesis of chiral phthalides via synergetic nitrile accelerated oxidative cyclization of o-cyano substituted aryl alkenes in high yield and enantiomeric excess (ee) in short reaction time. Also, disclosed herein is "one -pot" asymmetric synthesis of biologically important natural compounds having 3-substituted chiral phthalide structural framework in the molecule.

Abstract translation: 本发明公开了用于合成3-取代的手性苯并二氮杂环酮的单步高度对映选择性催化氧化环化方法。 特别地，本发明公开了通过协同腈在低反应时间内以高收率和对映异构体过量（ee）加速氧化环化邻氰基取代的芳族烯烃的不对称合成方法。 此外，本文公开了在分子中具有3-取代的手性苯并二氮苯结构框架的生物重要天然化合物的“一 - ”不对称合成。

公开(公告)号：IN1661DE2013A

公开(公告)日：2015-07-10

申请号：IN1661DE2013

申请日：2013-06-03

Applicant: COUNCIL SCIENT IND RES

Inventor： ARUMUGAM SUDALAI ,  RAMBABU REDDI ,  PUSHPA MALEKAR

IPC: C07D20060101 ,  C07J20060101

Abstract: A regioselective N-Heterocyclic Carbene (NHC) catalyzed one step process for high yield synthesis of a-acyloxy carbonyl compounds is disclosed.

公开(公告)号：IN83DE2012A

公开(公告)日：2015-05-01

申请号：IN83DE2012

申请日：2012-01-10

Applicant: COUNCIL SCIENT IND RES

Inventor： REDDY SANTHOSH REKULA ,  PRAGATI KISHORE PRASAD ,  BRIJ BHUSHAN AHUJA ,  ARUMUGAM SUDALAI

IPC: C07C20060101

Abstract: This invention relates to cheaper and practical protocol for the construction of a wide variety of 1-Amino-2-naphthalenecarboxylic acid derivatives and their structural analogues that proceeds with high yields in a single step via intramolecular cascade cyano ene reaction.

公开(公告)号：IN82DE2012A

公开(公告)日：2015-05-01

申请号：IN82DE2012

申请日：2012-01-10

Applicant: COUNCIL SCIENT IND RES

Inventor： SUNITA KHANDERAO GADAKH ,  REDDY SANTHOSH REKULA ,  ARUMUGAM SUDALAI

IPC: C12N20060101

Abstract: The invention relates to a novel process for the synthesis of HIV protease inhibitors. More particularly, the invention relates to the synthesis of HIV protease inhibitorssuch as AmprenavirFosamprenavir,Darunavir and sequinavirvia synazido epoxide with high enantiomeric excessas a common intermediateobtained by Co-catalyzed hydrolytic kinetic resolution of anti-(2SR, 3SR)-3-azido-4-phenyl-l, 2-epoxybutane.

公开(公告)号：ES2351400T3

公开(公告)日：2011-02-04

申请号：ES04798842

申请日：2004-11-09

Applicant: COUNCIL SCIENT IND RES

Inventor： BAVIKAR SUDHIR ,  MANER ASIF ,  ARUMUGAM SUDALAI ,  SWAMINATHAN SIVARAM ,  CHIDAMBARAM RAMESH

IPC: C07C231/12 ,  C07C209/36 ,  C07C209/50 ,  C07C211/50 ,  C07C211/52 ,  C07C233/43 ,  C07C237/32

Abstract: Un procedimiento para la producción de 3,3',4,4'-tetraaminobifenilo (TAB) de fórmula 1, a partir de 2-nitro-4-bromoacetanilida (NBA) de fórmula 2, dicho procedimiento que comprende las etapas de: (a) reacción de un compuesto de fórmula 2, con ácido nitroacetamidofenilborónico (NABP) de fórmula 3, en presencia de un catalizador, un disolvente y una base para obtener 3,3'dinitro-4,4'-diacetamidobifenilo (DNDAcB) de fórmula 4, (b) hidrólisis de dicho 3,3'-dinitro-4,4'-diacetamidobifenilo (DNDAcB) de fórmula 4 para obtener 3,3'-dinitro-4,4'-diaminobifenilo (DNDAB) de fórmula 5, y (c) reducción de dicho 3,3'-dinitro-4,4'-diaminobifenilo (DNDAB) de fórmula 5 para obtener 3,3',4,4'-tetraaminobifenilo (TAB) de fórmula 1.

公开(公告)号：DE602004029286D1

公开(公告)日：2010-11-04

申请号：DE602004029286

申请日：2004-11-09

Applicant: COUNCIL SCIENT IND RES

Inventor： BAVIKAR SUDHIR ,  MANER ASIF ,  CHIDAMBARAM RAMESH KUMAR ,  ARUMUGAM SUDALAI ,  SWAMINATHAN SIVARAM

IPC: C07C231/12 ,  C07C209/36 ,  C07C209/50 ,  C07C211/50 ,  C07C211/52 ,  C07C233/43 ,  C07C237/32

公开(公告)号：IN1685DE2012A

公开(公告)日：2015-10-02

申请号：IN1685DE2012

申请日：2012-06-01

Applicant: COUNCIL SCIENT IND RES

Inventor： CHAITHANYA KIRAN INDUKURU NAGA ,  KOMAL GIRDHARILAL LALWANI ,  SANTHOSH REDDY REKULA ,  ARUMUGAM SUDALAI

IPC: C07C20060101

Abstract: This invention relates to an efficient, cheaper, practical and ambient protocol for the synthesis of wide variety of esters that proceeds with high yields in single step. More particularly, the invention relates to preparation of variety of esters by activating both aldehyde and alcohol with the help of catalytic amount of N-Heterocyclic carbine during the esterification.

公开(公告)号：IN664DE2012A

公开(公告)日：2015-08-21

申请号：IN664DE2012

申请日：2012-03-07

Applicant: COUNCIL SCIENT IND RES

Inventor： BRIJ BHUSHAN AHUJA ,  REDDY SANTOSH REKULA ,  ARUMUGAM SUDALAI

IPC: C07C20060101

Abstract: The present invention discloses a cheaper and practical protocol for the construction of a wide variety of o-cyanocinnamonitrile and their structural analogues that proceeds with good yields in a single step using CuCN as the only reagent.