Abstract:
Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
Abstract:
Un sorbente para un mediador inflamatorio para su uso en un método para tratar la inflamación sistémica, regional o local de un paciente que padece o está en riesgo de inflamación, en el que dicho método comprende la etapa de administrar a dicho paciente el sorbente y en el que dicho sorbente es un polímero biocompatible que es: un polímero que comprende restos de monómeros divinilbenceno y etilvinilbenceno; o un copolímero de estireno o divinilbenceno poroso altamente reticulado, en el que dicho copolímero de estireno o divinilbenceno poroso altamente reticulado es: a) un copolímero de estireno-divinilbenceno-etilestireno macroporoso o mesoporoso sometido a una clorometilación parcial a un contenido de cloro de hasta 7 % de peso molecular; o b) un poliestireno hiperreticulado producido a partir de copolímeros de estireno reticulado mediante una clorometilación extensa y una posterior posreticulación mediante tratamiento con un catalizador de Friedel- Crafts en un estado hinchado; o c) un poliestireno hiperreticulado producido a partir de copolímeros de estireno reticulados mediante una reticulación posterior adicional extensa en un estado hinchado con agentes de reticulación bifuncionales seleccionados del grupo que comprende éter de monoclorodimetilo y dicloruro de p-xilileno.
Abstract:
Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
Abstract:
Connector assemblies and methods of replacing components in an extra-corporeal circuit (ECC) system are disclosed. A connector assembly for use in an ECC system includes a tubular body having an inner surface defining a lumen extending through the tubular body with the lumen extending along a longitudinal axis, a first connection interface in fluid communication with the lumen, a second connection interface in fluid communication with the lumen, and a plurality of closure mechanisms, each closure mechanism being configured to occlude the lumen.
Abstract:
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
Abstract:
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
Abstract:
This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
Abstract:
The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
Abstract:
La presente invención es concerniente con métodos de tratamiento de inflamación sistémica, regional o local de un paciente que sufre o está en riesgo de inflamación que comprende la administración de una dosis terapéuticamente efectiva de un sorbente que absorbe un mediador inflamatorio en dicho paciente. En algunas modalidades preferidas, el sorbente es un polímero orgánico biocompartible.