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公开(公告)号：WO2008128546A1
公开(公告)日：2008-10-30
申请号：PCT/DK2008/050090
申请日：2008-04-17
Applicant: COLOPLAST A/S , HASSINGBOE, Jens , VANGE, Jacob , EVERLAND, Hanne , WEIMIN, Rong
Inventor： HASSINGBOE, Jens , VANGE, Jacob , EVERLAND, Hanne , WEIMIN, Rong
IPC: A61L15/32
CPC classification number: A61F13/00987 , A61L15/32
Abstract: The formation of a non-woven, free from organic solvent, formed through parallel formation of fibers on a collection device is disclosed. As the individual fibers are dry prior to contact with other fibers, the different contents of the various fiber types do not interact. However, when wetted, the fibers will start to be dissolved, or swell, and the different contents will be released and then interact. For the example of thrombin and fibrinogen, the interaction will initiate the formation of a fibrin coagulum by the cleavage of fibrinogen through the action of thrombin to form fibrin monomers that spontaneously polymerize to form a three dimensional network of fibrin.
Abstract translation: 公开了通过在收集装置上平行形成纤维而形成无机织物，无机溶剂。 由于单个纤维在与其他纤维接触之前是干燥的，所以各种纤维类型的不同内容不相互作用。 然而，当润湿时，纤维将开始溶解或膨胀，并且不同的内容物将被释放并且然后相互作用。 对于凝血酶和纤维蛋白原的实例，相互作用将通过凝血酶的作用通过纤维蛋白原的切割引发纤维蛋白凝结物的形成，从而形成自发聚合以形成纤维蛋白的三维网络的纤维蛋白单体。
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Patent Agency Ranking
公开(公告)号：WO2008107482A1
公开(公告)日：2008-09-12
申请号：PCT/EP2008/052781
申请日：2008-03-07
Applicant: COLOPLAST A/S , EVERLAND, Hanne , VANGE, Jacob , CLAUSEN, Christian , NIELSEN, Lene Feldskov
Inventor： EVERLAND, Hanne , VANGE, Jacob , CLAUSEN, Christian , NIELSEN, Lene Feldskov
CPC classification number: A61L27/56 , A61L27/48 , A61L27/58 , A61L2430/06 , C08L5/08 , C08L71/02 , C08L67/04
Abstract: The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form.
Abstract translation: 本申请公开了在某些聚合物的复合支架中掺入硫酸皮肤素和/或HA导致对软骨细胞的软骨形成作用，导致形成类似于天然ECM的软骨。 以前没有看到这种硫酸皮肤素作为主要添加剂的效果。 通过将硫酸皮肤素精细分散的颗粒任选地纳入纳米颗粒或作为分子溶解在聚合物基质中，在DS和基质之间没有结合形成复合物，以可接近的非交联形式向软骨细胞提供DS。
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公开(公告)号：EP2131881A1
公开(公告)日：2009-12-16
申请号：EP08717528.7
申请日：2008-03-07
Applicant: Coloplast A/S
Inventor： EVERLAND, Hanne , VANGE, Jacob , CLAUSEN, Christian , NIELSEN, Lene Feldskov
CPC classification number: A61L27/56 , A61L27/48 , A61L27/58 , A61L2430/06 , C08L5/08 , C08L71/02 , C08L67/04
Abstract: The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form.
Abstract translation: 本申请公开了在某些聚合物的复合支架中掺入硫酸皮肤素和/或HA导致对软骨细胞的软骨形成作用，导致形成类似于天然ECM的软骨。 以硫酸皮肤素为主要添加剂的这种作用以前从未见过。 通过将硫酸皮肤素精细分散的颗粒任选地纳入纳米颗粒或作为分子溶解于DS和基质之间没有结合的聚合物基质中形成复合物，以可接近的非交联形式向软骨细胞提供DS。
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公开(公告)号：EP2131881B1
公开(公告)日：2010-11-17
申请号：EP08717528.7
申请日：2008-03-07
Applicant: Coloplast A/S
Inventor： EVERLAND, Hanne , VANGE, Jacob , CLAUSEN, Christian , NIELSEN, Lene Feldskov
CPC classification number: A61L27/56 , A61L27/48 , A61L27/58 , A61L2430/06 , C08L5/08 , C08L71/02 , C08L67/04
Abstract: The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form.
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公开(公告)号：EP2148704A1
公开(公告)日：2010-02-03
申请号：EP08734545.0
申请日：2008-04-17
Applicant: Coloplast A/S
Inventor： HASSINGBOE, Jens , VANGE, Jacob , EVERLAND, Hanne , WEIMIN, Rong
IPC: A61L15/32
CPC classification number: A61F13/00987 , A61L15/32
Abstract: The formation of a non-woven, free from organic solvent, formed through parallel formation of fibers on a collection device is disclosed. As the individual fibers are dry prior to contact with other fibers, the different contents of the various fiber types do not interact. However, when wetted, the fibers will start to be dissolved, or swell, and the different contents will be released and then interact. For the example of thrombin and fibrinogen, the interaction will initiate the formation of a fibrin coagulum by the cleavage of fibrinogen through the action of thrombin to form fibrin monomers that spontaneously polymerize to form a three dimensional network of fibrin.
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公开(公告)号：EP2148704B1
公开(公告)日：2017-06-21
申请号：EP08734545.0
申请日：2008-04-17
Applicant: Coloplast A/S
Inventor： HASSINGBOE, Jens , VANGE, Jacob , EVERLAND, Hanne , WEIMIN, Rong
CPC classification number: A61F13/00987 , A61L15/32
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