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    SCAFFOLDS FOR THE REGENERATION OF CARTILAGE
    1.
    发明申请
    SCAFFOLDS FOR THE REGENERATION OF CARTILAGE 审中-公开
    用于再生卡片的药物

    公开(公告)号：WO2008107482A1

    公开(公告)日：2008-09-12

    申请号：PCT/EP2008/052781

    申请日：2008-03-07

    Applicant: COLOPLAST A/S ,  EVERLAND, Hanne ,  VANGE, Jacob ,  CLAUSEN, Christian ,  NIELSEN, Lene Feldskov

    Inventor： EVERLAND, Hanne ,  VANGE, Jacob ,  CLAUSEN, Christian ,  NIELSEN, Lene Feldskov

    IPC: A61L27/48 ,  A61L27/56 ,  A61L27/58

    CPC classification number: A61L27/56 ,  A61L27/48 ,  A61L27/58 ,  A61L2430/06 ,  C08L5/08 ,  C08L71/02 ,  C08L67/04

    Abstract: The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form.

    Abstract translation: 本申请公开了在某些聚合物的复合支架中掺入硫酸皮肤素和/或HA导致对软骨细胞的软骨形成作用，导致形成类似于天然ECM的软骨。 以前没有看到这种硫酸皮肤素作为主要添加剂的效果。 通过将硫酸皮肤素精细分散的颗粒任选地纳入纳米颗粒或作为分子溶解在聚合物基质中，在DS和基质之间没有结合形成复合物，以可接近的非交联形式向软骨细胞提供DS。

    BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION
    2.
    发明申请
    BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION 审中-公开
    生物活性基质及其生产方法

    公开(公告)号：WO2009106642A1

    公开(公告)日：2009-09-03

    申请号：PCT/EP2009/052432

    申请日：2009-03-02

    Applicant: COLOPLAST A/S ,  EVERLAND, Hanne ,  SAMUELSEN, Peter ,  VANGE, Jakob ,  CLAUSEN, Christian ,  INTERFACE BIOTECH A/S

    Inventor： EVERLAND, Hanne ,  SAMUELSEN, Peter ,  VANGE, Jakob ,  CLAUSEN, Christian

    IPC: A61L27/38 ,  A61L27/54 ,  A61L27/58

    CPC classification number: A61L27/58 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414

    Abstract: An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained.

    Abstract translation: 提供了一种基本上没有合成可生物降解的脚手架结构的分离的，无细胞的生物合成软骨基质。 通过以下步骤的方法：a）将体细胞群体的软骨细胞与合成的生物可降解支架接触; b）在体外培养所述合成可生物降解的支架内的所述软骨形成细胞的一段时间，使得软骨形成细胞产生生物合成的软骨基质; c）基本上除去源自所述软骨形成细胞的任何抗原，获得适合植入活体个体哺乳动物（例如人）的基质。

    SCAFFOLDS FOR THE REGENERATION OF CARTILAGE
    4.
    发明公开
    SCAFFOLDS FOR THE REGENERATION OF CARTILAGE 有权
    GERÜSTEZUR REGENERATION VON KNORPEL

    公开(公告)号：EP2131881A1

    公开(公告)日：2009-12-16

    申请号：EP08717528.7

    申请日：2008-03-07

    Applicant: Coloplast A/S

    Inventor： EVERLAND, Hanne ,  VANGE, Jacob ,  CLAUSEN, Christian ,  NIELSEN, Lene Feldskov

    IPC: A61L27/48 ,  A61L27/56 ,  A61L27/58

    CPC classification number: A61L27/56 ,  A61L27/48 ,  A61L27/58 ,  A61L2430/06 ,  C08L5/08 ,  C08L71/02 ,  C08L67/04

    Abstract: The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form.

    Abstract translation: 本申请公开了在某些聚合物的复合支架中掺入硫酸皮肤素和/或HA导致对软骨细胞的软骨形成作用，导致形成类似于天然ECM的软骨。 以硫酸皮肤素为主要添加剂的这种作用以前从未见过。 通过将硫酸皮肤素精细分散的颗粒任选地纳入纳米颗粒或作为分子溶解于DS和基质之间没有结合的聚合物基质中形成复合物，以可接近的非交联形式向软骨细胞提供DS。

    BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION
    5.
    发明公开
    BIOSYNTHETIC CARTILAGINOUS MATRIX AND METHODS FOR THEIR PRODUCTION 审中-公开
    VERFAHREN ZU IHRER HERSTELLUNG的BIOSYNTHETISCHE KNORPELMATRIX

    公开(公告)号：EP2259806A1

    公开(公告)日：2010-12-15

    申请号：EP09714829.0

    申请日：2009-03-02

    Applicant: Coloplast A/S ,  Interface Biotech A/S

    Inventor： EVERLAND, Hanne ,  SAMUELSEN, Peter ,  VANGE, Jakob ,  CLAUSEN, Christian

    IPC: A61L27/38 ,  A61L27/54 ,  A61L27/58

    CPC classification number: A61L27/58 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414

    Abstract: An isolated, acellular biosynthetic cartilaginous matrix substantially devoid of synthetic biodegradable scaffold structure is provided. Through a method with the steps of a) contacting
    in vitro a population of chondrogenic cells with a synthetic biodegradable scaffold; b) culturing
    in vitro for a period of time said chondrogenic cells within said synthetic biodegradable scaffold so that the chondrogenic cells produce a biosynthetic cartilaginous matrix; c) substantially removing any antigen derived from said chondrogenic cells a matrix suitable of implantation into a living individual mammal, such as a human being is obtained.

    Abstract translation: 提供了一种基本上没有合成可生物降解的脚手架结构的分离的，无细胞的生物合成软骨基质。 通过以下步骤的方法：a）将体细胞群体的软骨细胞与合成的可生物降解的支架接触; b）在体外培养所述合成可生物降解的支架内所述软骨形成细胞的一段时间，使得软骨形成细胞产生生物合成软骨基质; c）基本上除去源自所述软骨形成细胞的任何抗原，获得适合植入活体个体哺乳动物（例如人）的基质。

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