公开(公告)号：BG62998B1

公开(公告)日：2001-01-31

申请号：BG10300598

申请日：1998-12-09

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMUELLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF ,  THOMAS KLAUS-PETER

IPC: A61K8/21 ,  A61K8/25 ,  A61Q11/00 ,  A61K7/16 ,  A61K7/18

Abstract: The acids can be applied by adding them to substances for maintaining oral hygiene - in tooth pastes, topic fluoride preparation, dental materials or medical chewing gums. They have specific, delayed release of the active substance. They are produced by adding the active substance in the preparation of the sedimental silicic acid in the known manner. 4 claims, 2 figures

公开(公告)号：BR9805265A

公开(公告)日：2000-04-11

申请号：BR9805265

申请日：1998-12-10

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMUELLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF ,  THOMAS KLAUS-PETER

IPC: A61K8/21 ,  A61K8/25 ,  A61Q11/00 ,  A61K7/18 ,  A61P1/02

Abstract: A precipitated silica which contains an active substance with a characteristic, delayed release of active substance is prepared by adding the active substance during preparation of the precipitated silica. The precipitated silica containing the active substance may be added to oral hygiene agents such as toothpastes, topical fluoride preparations, dental materials or medicinal chewing gums.

公开(公告)号：BG103005A

公开(公告)日：1999-07-30

申请号：BG10300598

申请日：1998-12-09

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMUELLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF ,  THOMAS KLAUS-PETER

IPC: A61K8/21 ,  A61K8/25 ,  A61Q11/00 ,  A61K7/18

Abstract: The acids can be applied by adding them to substances formaintaining oral hygiene - in toothpastes, topic fluoridepreparation, dental materials or medical chewing gums. They havespecific, delayed release of the active substance. They areproduced by adding the active substance in the preparation of thesedimented silicic acid in the known manner.4 claims

公开(公告)号：DE19803066A1

公开(公告)日：1999-06-24

申请号：DE19803066

申请日：1998-01-28

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMUELLER MATTHIAS ,  OTTO KARIN DR ,  RAUSCH RALF DR ,  THOMAS KLAUS-PETER

IPC: A61K8/25 ,  A61Q11/00 ,  A61K7/18

Abstract: Precipitated silica that contains an active agent and provides delayed release of the active agent is new. Also claimed is a process for preparing a product as above, in which precipitated silica is produced in known manner and a moderately to sparingly water-soluble active agent is added to the precipitation medium or the precipitate suspension or is dried together with the washed and optionally redispersed silica paste or is ground together with the dried material.

公开(公告)号：BG61063B1

公开(公告)日：1996-10-31

申请号：BG9528391

申请日：1991-10-08

Applicant: DEGUSSA

Inventor： AGAIN IVAN A ,  BOJANOVA VERA I ,  OTTO KARIN ,  NEUMUELLER MATTHIAS ,  DIPPMANN HARALD

IPC: A61K8/73 ,  A61Q11/00 ,  A61K7/16

Abstract: The preparation for the care of the teeth consists of the customary known ingredients of a preparation for the care of the teeth and contains as abrasive component cellulose powder in place of customary known polishing particles.

公开(公告)号：NO315645B1

公开(公告)日：2003-10-06

申请号：NO942882

申请日：1994-08-03

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMUELLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF

IPC: A61K8/00 ,  A61K8/25 ,  A61Q11/00 ,  C01B33/193

Abstract: Precipitated silica having a BET surface area of 10-130 m /g, a CTAB surface area of 10-70 m /g, a mean particle diameter of 5-20 mu m, a Cu abrasion in 10% strength glycerol (glycerine) dispersion of 4-50 mg and a thickening behaviour in CMC solution (20% strength dispersion) of 300-3500 mPa.s is prepared by simultaneously adding alkali metal silicate (weight ratio SiO2: alkali metal oxide = 2.5-3.9:1) and a mineral acid to an initial charge of water which has been adjusted to a pH of from 7.0 to 9.9 or from 10.0 to 10.7 by addition of water, keeping the pH constant between 7.0 and 9.9 or 10.0 and 10.7, with the initial precipitation temperature being 50-90 DEG C and a viscosity increase commencing at the latest after 25% of the precipitation time, setting the pH to /= 160 g/l to 240 g/l, separating off the solid by filtration and washing, drying and milling it. The precipitated silica can be used as abrasive and/or thickening component in toothpastes.

公开(公告)号：PL330178A1

公开(公告)日：1999-06-21

申请号：PL33017898

申请日：1998-12-09

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMUELLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF ,  THOMAS KLAUS-PETER

IPC: A61K8/21 ,  A61K8/25 ,  A61Q11/00 ,  C01B33/00 ,  A61K7/18

Abstract: A precipitated silica which contains an active substance with a characteristic, delayed release of active substance is prepared by adding the active substance during preparation of the precipitated silica. The precipitated silica containing the active substance may be added to oral hygiene agents such as toothpastes, topical fluoride preparations, dental materials or medicinal chewing gums.

公开(公告)号：CA2129607A1

公开(公告)日：1995-02-08

申请号：CA2129607

申请日：1994-08-05

Applicant: ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMUELLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF ,  DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMUELLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF

IPC: A61K8/00 ,  A61K8/25 ,  A61Q11/00 ,  C01B33/193 ,  C01B33/12 ,  A61K7/16

Abstract: Precipitated silica having a BET surface area of 10-130 m /g, a CTAB surface area of 10-70 m /g, a mean particle diameter of 5-20 mu m, a Cu abrasion in 10% strength glycerol (glycerine) dispersion of 4-50 mg and a thickening behaviour in CMC solution (20% strength dispersion) of 300-3500 mPa.s is prepared by simultaneously adding alkali metal silicate (weight ratio SiO2: alkali metal oxide = 2.5-3.9:1) and a mineral acid to an initial charge of water which has been adjusted to a pH of from 7.0 to 9.9 or from 10.0 to 10.7 by addition of water, keeping the pH constant between 7.0 and 9.9 or 10.0 and 10.7, with the initial precipitation temperature being 50-90 DEG C and a viscosity increase commencing at the latest after 25% of the precipitation time, setting the pH to /= 160 g/l to 240 g/l, separating off the solid by filtration and washing, drying and milling it. The precipitated silica can be used as abrasive and/or thickening component in toothpastes.

公开(公告)号：FI943648A0

公开(公告)日：1994-08-05

申请号：FI943648

申请日：1994-08-05

Applicant: DEGUSSA

Inventor： ESCH HEINZ ,  KUHLMANN ROBERT ,  NEUMUELLER MATTHIAS ,  OTTO KARIN ,  RAUSCH RALF

IPC: A61K8/00 ,  A61K8/25 ,  A61Q11/00 ,  C01B33/193 ,  C09C ,  A61K

Abstract: Precipitated silica having a BET surface area of 10-130 m /g, a CTAB surface area of 10-70 m /g, a mean particle diameter of 5-20 mu m, a Cu abrasion in 10% strength glycerol (glycerine) dispersion of 4-50 mg and a thickening behaviour in CMC solution (20% strength dispersion) of 300-3500 mPa.s is prepared by simultaneously adding alkali metal silicate (weight ratio SiO2: alkali metal oxide = 2.5-3.9:1) and a mineral acid to an initial charge of water which has been adjusted to a pH of from 7.0 to 9.9 or from 10.0 to 10.7 by addition of water, keeping the pH constant between 7.0 and 9.9 or 10.0 and 10.7, with the initial precipitation temperature being 50-90 DEG C and a viscosity increase commencing at the latest after 25% of the precipitation time, setting the pH to /= 160 g/l to 240 g/l, separating off the solid by filtration and washing, drying and milling it. The precipitated silica can be used as abrasive and/or thickening component in toothpastes.

公开(公告)号：DE4113044A1

公开(公告)日：1992-05-21

申请号：DE4113044

申请日：1991-04-22

Applicant: DEGUSSA

Inventor： AGAIN IVAN PROF ,  BOYANOVA VERA PROF ,  OTTO KARIN DR ,  NEUMUELLER MATTHIAS ,  DIPPMANN HARALD

IPC: A61K8/73 ,  A61Q11/00

Abstract: The preparation for the care of the teeth consists of the customary known ingredients of a preparation for the care of the teeth and contains as abrasive component cellulose powder in place of customary known polishing particles.