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公开(公告)号：JPH11236325A
公开(公告)日：1999-08-31
申请号：JP34721498
申请日：1998-12-07
Applicant: DEGUSSA
Inventor： ESCH HEINZ , KUHLMANN ROBERT , NEUMUELLER MATTIAS , OTTO KARIN , RAUSCH RALF DR , THOMAS KLAUS-PETER
Abstract: PROBLEM TO BE SOLVED: To prepare the subject silicic acid capable of satisfying requirements for a medicine concerning compatibility, rheology characteristics, sensory irritation and the like, capable of fixing an active material in an oral cavity and allowing the active material to be controllably released, and useful as an oral hygienic good such as a toothpaste by allowing the active material to be carried. SOLUTION: This precipitated silicic acid containing an active material can carry out the sustained lease of the active material [e.g. a fluoride ion-containing material such as an alkali (alkaline earth) metal fluoride and fluoroapatite], and is prepared, for example, by previously inserting water and the active material in a precipitation vessel, heating the obtained mixture at 50-100 deg.C, adding (Z) a sodium silicate solution to the heated mixture while keeping the temperature to regulate the pH or the alkali metal content of the mixture, further adding the component Z and sulfuric acid while keeping the pH or the content of the alkali metal constant, further adding the sulfuric acid to acidify the obtained mixture so as to have pH 7, optionally carrying out an after-stirring of the resultant mixture, filtering and washing the resultant mixture, redispersing the obtained filtration cake, drying the redispersed filtration cake by a spray drier, and pulverizing the obtained dried silicic acid granule.
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公开(公告)号：NZ333198A
公开(公告)日：2000-04-28
申请号：NZ33319898
申请日：1998-12-07
Applicant: DEGUSSA
Inventor： ESCH HEINZ , KUHLMANN ROBERT , NEUMULLER MATTHIAS , OTTO KARIN , RAUSCH RALF , THOMAS KLAUS-PETER
Abstract: Oral hygiene compositions, particularly toothpastes, comprise precipitated silica which contains an active substance in delayed release form. The active substance can contain fluoride ions.
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公开(公告)号：CA2255398A1
公开(公告)日：1999-06-10
申请号：CA2255398
申请日：1998-12-09
Applicant: DEGUSSA
Inventor： ESCH HEINZ , THOMAS KLAUS-PETER , RAUSCH RALF , OTTO KARIN , NEUMUELLER MATTHIAS , KUHLMANN ROBERT
Abstract: A precipitated silica which contains an active substance having a delayed, release of active substance is prepared by adding the active substance during preparation of the precipitated silica. The precipitated silica may be added to oral hygiene agents such as toothpastes, topical fluoride preparations, dental materials or medicinal chewing gums.
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公开(公告)号：ZA9811286B
公开(公告)日：1999-06-09
申请号：ZA9811286
申请日：1998-12-09
Applicant: DEGUSSA
Inventor： ESCH HEINZ , KUHLMANN ROBERT , NEUMUELLER MATTHIAS , OTTO KARIN , RAUSCH RALF , THOMAS KLAUS-PETER
Abstract: Precipitated silica that contains an active agent and provides delayed release of the active agent is new. Also claimed is a process for preparing a product as above, in which precipitated silica is produced in known manner and a moderately to sparingly water-soluble active agent is added to the precipitation medium or the precipitate suspension or is dried together with the washed and optionally redispersed silica paste or is ground together with the dried material.
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公开(公告)号：PL330178A1
公开(公告)日：1999-06-21
申请号：PL33017898
申请日：1998-12-09
Applicant: DEGUSSA
Inventor： ESCH HEINZ , KUHLMANN ROBERT , NEUMUELLER MATTHIAS , OTTO KARIN , RAUSCH RALF , THOMAS KLAUS-PETER
Abstract: A precipitated silica which contains an active substance with a characteristic, delayed release of active substance is prepared by adding the active substance during preparation of the precipitated silica. The precipitated silica containing the active substance may be added to oral hygiene agents such as toothpastes, topical fluoride preparations, dental materials or medicinal chewing gums.
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Patent Agency Ranking
公开(公告)号：BG62998B1
公开(公告)日：2001-01-31
申请号：BG10300598
申请日：1998-12-09
Applicant: DEGUSSA
Inventor： ESCH HEINZ , KUHLMANN ROBERT , NEUMUELLER MATTHIAS , OTTO KARIN , RAUSCH RALF , THOMAS KLAUS-PETER
Abstract: The acids can be applied by adding them to substances for maintaining oral hygiene - in tooth pastes, topic fluoride preparation, dental materials or medical chewing gums. They have specific, delayed release of the active substance. They are produced by adding the active substance in the preparation of the sedimental silicic acid in the known manner. 4 claims, 2 figures
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公开(公告)号：BR9805265A
公开(公告)日：2000-04-11
申请号：BR9805265
申请日：1998-12-10
Applicant: DEGUSSA
Inventor： ESCH HEINZ , KUHLMANN ROBERT , NEUMUELLER MATTHIAS , OTTO KARIN , RAUSCH RALF , THOMAS KLAUS-PETER
Abstract: A precipitated silica which contains an active substance with a characteristic, delayed release of active substance is prepared by adding the active substance during preparation of the precipitated silica. The precipitated silica containing the active substance may be added to oral hygiene agents such as toothpastes, topical fluoride preparations, dental materials or medicinal chewing gums.
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公开(公告)号：BG103005A
公开(公告)日：1999-07-30
申请号：BG10300598
申请日：1998-12-09
Applicant: DEGUSSA
Inventor： ESCH HEINZ , KUHLMANN ROBERT , NEUMUELLER MATTHIAS , OTTO KARIN , RAUSCH RALF , THOMAS KLAUS-PETER
Abstract: The acids can be applied by adding them to substances formaintaining oral hygiene - in toothpastes, topic fluoridepreparation, dental materials or medical chewing gums. They havespecific, delayed release of the active substance. They areproduced by adding the active substance in the preparation of thesedimented silicic acid in the known manner.4 claims
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公开(公告)号：DE19803066A1
公开(公告)日：1999-06-24
申请号：DE19803066
申请日：1998-01-28
Applicant: DEGUSSA
Inventor： ESCH HEINZ , KUHLMANN ROBERT , NEUMUELLER MATTHIAS , OTTO KARIN DR , RAUSCH RALF DR , THOMAS KLAUS-PETER
Abstract: Precipitated silica that contains an active agent and provides delayed release of the active agent is new. Also claimed is a process for preparing a product as above, in which precipitated silica is produced in known manner and a moderately to sparingly water-soluble active agent is added to the precipitation medium or the precipitate suspension or is dried together with the washed and optionally redispersed silica paste or is ground together with the dried material.
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公开(公告)号：TR9802573A2
公开(公告)日：1999-06-21
申请号：TR9802573
申请日：1998-12-10
Applicant: DEGUSSA
Inventor： ESCH HEINZ , KUHLMANN ROBERT , NEUMULLER MATTHIAS , OTTO DR KARIN , RAUSCH DR RALF , THOMAS KLAUS-PETER
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