公开(公告)号：JP2012085659A

公开(公告)日：2012-05-10

申请号：JP2012020787

申请日：2012-02-02

Applicant: Fluidigm Corp ,  フルイディグム コーポレイション

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

IPC: C12N15/09 ,  C12M1/00 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide devices that can be utilized to conduct a variety of nucleic acid amplification reactions, while having sufficient versatility for use in other types of analyses as well.SOLUTION: An M×N matrix microfluidic device for performing a matrix of reactions is disclosed. This device (100) has a plurality of reaction cells (106) in communication with one of either a sample inlet (120) or a reagent inlet (124) through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of the microfluidic device. The method includes a step of using patterned photoresist masks and a step of etching regions or portions of an elastomeric layer of the elastomeric block.

Abstract translation: 要解决的问题：提供可用于进行各种核酸扩增反应的装置，同时具有用于其它类型分析的足够多功能性。 解决方案：公开了一种用于执行反应矩阵的M×N矩阵微流体装置。 该装置（100）具有通过形成在装置的弹性体块内的通孔与样品入口（120）或试剂入口（124）中的一个连通的多个反应池（106）。 提供的方法包括在微流体装置的弹性体层中平行地形成通孔的方法。 该方法包括使用图案化的光致抗蚀剂掩模和蚀刻弹性体块的弹性层的区域或部分的步骤。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：WO2005107938A3

公开(公告)日：2006-01-12

申请号：PCT/US2005015352

申请日：2005-05-02

Applicant: FLUIDIGM CORP ,  GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

IPC: B01J3/00 ,  B01J4/00 ,  B01J10/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  B01L3/02 ,  G01N15/06 ,  G01N21/00 ,  G01N31/22

CPC classification number: B01L7/52 ,  B01J19/0046 ,  B01J2219/00353 ,  B01J2219/004 ,  B01J2219/00403 ,  B01J2219/00495 ,  B01J2219/00576 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/502738 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1805 ,  B01L2400/0481 ,  B01L2400/0638

Abstract: An M x N matrix microfluidic device for performing a matrix of reactions, the device (100) having a plurality of reaction cells (106) in communication with one of either a sample inlet (120) or a reagent t inlet (124) through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method includes using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.

Abstract translation: 一种用于执行反应矩阵的M×N矩阵微流体装置，所述装置（100）具有多个反应池（106），其通过样品入口（120）或试剂t入口（124）中的一个通过 通过形成在装置的弹性体块内。 提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。

公开(公告)号：SG166024A1

公开(公告)日：2010-11-29

申请号：SG2009028630

申请日：2005-05-02

Applicant: FLUIDIGM CORP

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

Abstract: An M x N matrix microfluidic device for performing a matrix of reactions, the device (100) having a plurality of reaction cells (106) in communication with one of either a sample inlet (120) or a reagent t inlet (124) through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method includes using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block. Fig. 1A

公开(公告)号：SG2013006333A

公开(公告)日：2014-08-28

申请号：SG2013006333

申请日：2005-05-02

Applicant: FLUIDIGM CORP

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

公开(公告)号：EP1796824A4

公开(公告)日：2016-10-19

申请号：EP05766055

申请日：2005-05-02

Applicant: FLUIDIGM CORP

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

IPC: G01N21/00 ,  B01J3/00 ,  B01J4/00 ,  B01J10/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N15/06 ,  G01N31/22

CPC classification number: B01L7/52 ,  B01J19/0046 ,  B01J2219/00353 ,  B01J2219/004 ,  B01J2219/00403 ,  B01J2219/00495 ,  B01J2219/00576 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/502738 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1805 ,  B01L2400/0481 ,  B01L2400/0638