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    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION
    4.
    发明申请
    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION 审中-公开
    具有可拆卸盖的微流体装置以及制造和应用方法

    公开(公告)号：WO2011040884A2

    公开(公告)日：2011-04-07

    申请号：PCT/SG2010/000369

    申请日：2010-09-29

    Applicant: FLUIDIGM CORPORATION ,  COHEN, David ,  MAY, Andrew ,  PIEPRZYK, Martin ,  FOWLER, Brian ,  LEE, Kim Huat ,  YAN, Jun ,  ZHOU, Ming Fang ,  NG, Seng Beng

    Inventor： COHEN, David ,  MAY, Andrew ,  PIEPRZYK, Martin ,  FOWLER, Brian ,  LEE, Kim Huat ,  YAN, Jun ,  ZHOU, Ming Fang ,  NG, Seng Beng

    IPC: G01N35/08 ,  G01N33/48

    CPC classification number: B01L3/5027 ,  B01L3/502738 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/12 ,  B01L2300/045 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  G01N1/405

    Abstract: The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.

    Abstract translation: 本发明包括具有微型空腔的​​微流体系统，其可以被可移除的盖覆盖，其中可移除的盖允许微加工腔的至少一部分开口被操作者暴露或直接访问。 微流体系统包括在可包括PDMS的弹性体层中形成的腔室，流动和控制通道。 可移除的盖包括通过粘合剂层结合到弹性体层的热塑性基底膜。 当可移除的盖被剥离时，室至少部分地打开以允许从室中取样。 该室可能在PCR反应内部形成大分子晶体或产生内含物。 本发明还包括通过使用可移除盖制造弹性体层中的通孔的方法。 本发明还包括用于剥离可剥离盖或诸如集成式加热器撒布机的可移除部件的方法和装置。

    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION
    8.
    发明申请
    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION 审中-公开
    具有可移除覆盖层的微流体器件以及制造和应用方法

    公开(公告)号：WO2011040884A3

    公开(公告)日：2011-06-03

    申请号：PCT/SG2010000369

    申请日：2010-09-29

    Applicant: FLUIDIGM CORP ,  COHEN DAVID ,  MAY ANDREW ,  PIEPRZYK MARTIN ,  FOWLER BRIAN ,  LEE KIM HUAT ,  YAN JUN ,  ZHOU MING FANG ,  NG SENG BENG

    Inventor： COHEN DAVID ,  MAY ANDREW ,  PIEPRZYK MARTIN ,  FOWLER BRIAN ,  LEE KIM HUAT ,  YAN JUN ,  ZHOU MING FANG ,  NG SENG BENG

    IPC: G01N35/08 ,  G01N33/48

    CPC classification number: B01L3/5027 ,  B01L3/502738 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/12 ,  B01L2300/045 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0655 ,  G01N1/405

    Abstract: The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.

    Abstract translation: 本发明包括具有可用可移除覆盖物覆盖的微制造腔体的微流体系统，其中可移除覆盖物允许微制造腔体的至少部分开口被操作员暴露或直接存取。 微流体系统包括腔室，形成在可包含PDMS的弹性体层中的流动和控制通道。 可移除的盖子包括通过粘合层粘合到弹性体层的热塑基膜。 当可移除盖子被剥离时，腔室至少部分打开以允许从腔室抽取样品。 室内可能形成大分子晶体或由PCR反应产生内容物。 本发明还包括一种通过使用可移除盖子来制造弹性体层中的通孔的方法。 本发明进一步包括用于剥离可剥离盖或诸如集成式加热器分散器的可移除部件的方法和装置。

    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME
    10.
    发明申请
    CRYSTAL FORMING DEVICES AND SYSTEMS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
    晶体形成装置和系统及其制造和使用方法

    公开(公告)号：WO2005072353A2

    公开(公告)日：2005-08-11

    申请号：PCT/US2005/002408

    申请日：2005-01-25

    Applicant: FLUIDIGM CORPORATION ,  GROSSMAN, Robert ,  UNGER, Marc ,  LAM, Phillip ,  CHOU, Hou-Pu ,  KIMBALL, Jake ,  PIEPRZYK, Martin

    Inventor： GROSSMAN, Robert ,  UNGER, Marc ,  LAM, Phillip ,  CHOU, Hou-Pu ,  KIMBALL, Jake ,  PIEPRZYK, Martin

    IPC: B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58

    CPC classification number: C12Q1/68 ,  B01L3/0293 ,  B01L3/06 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/5635 ,  B01L3/565 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0655 ,  C30B7/00 ,  C30B29/58 ,  Y10T436/11

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.

    Abstract translation: 本发明提供了微流体装置及其使用方法。 本发明还提供了用于使用微流体装置的装置和系统，分析在微流体装置中进行的反应，以及用于生成，存储，组织和分析使用微流体装置产生的数据的系统。 本发明还提供了使用和制造微流体系统和装置的方法，在一些实施方案中，它们可用于晶体形成。 在一个实施例中，一种装置包括具有其中具有一个或多个流体端口的压板面的压板。 流体端口在空间上对应于微流体装置表面上的一个或多个孔。 包括用于相对于压板保持微流体装置的平台，以及用于将压板压靠在微流体装置上的压板致动器，使得压板的至少一个流体端口被推压到一个井中以形成压力室 包括井和端口，使得当压力流体通过其中一个端口被引入或从压力室移除时，流体压力在其中改变。

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