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    Recirculating fluidic network and methods for using the same
    6.
    发明专利
    Recirculating fluidic network and methods for using the same 未知

    公开(公告)号：AU2003277853A8

    公开(公告)日：2004-01-06

    申请号：AU2003277853

    申请日：2003-06-23

    Applicant: FLUIDIGM CORP

    Inventor： BARCO JOSEPH W ,  NASSEF HANY R ,  MANGER IAN D

    IPC: B01L3/00 ,  B81C20060101 ,  F04B19/00 ,  F04B43/02 ,  G01N21/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/566 ,  G01N37/00

    Abstract: A microfluidic device includes a plurality of first flow channels and a plurality of second flow channels, each such second flow channel intersecting multiple of the first flow channels to define intersecting volumes and a plurality of looped flow channels that each include segments of the flow channels between the intersecting volumes to define a closed loop. The microfluidic device also includes a plurality of control valves each such control valve having a control channel and a deformable segment disposed to restrict flow through a respective one of the first and second flow channels in response to an actuation force applied to the control channel to deflect the deformable segment. The microfluidic device further includes a pump operatively disposed to regulate flow through one of the looped flow channels to regulate flow by the recirculating pump.

    RECIRCULATING FLUIDIC NETWORK AND METHODS FOR USING THE SAME
    7.
    发明专利
    RECIRCULATING FLUIDIC NETWORK AND METHODS FOR USING THE SAME 未知

    公开(公告)号：AU2003277853A1

    公开(公告)日：2004-01-06

    申请号：AU2003277853

    申请日：2003-06-23

    Applicant: FLUIDIGM CORP

    Inventor： MANGER IAN D ,  BARCO JOSEPH W ,  NASSEF HANY R

    IPC: B01L3/00 ,  B81C20060101 ,  F04B19/00 ,  F04B43/02 ,  G01N21/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/566 ,  G01N37/00

    Abstract: A microfluidic device includes a plurality of first flow channels and a plurality of second flow channels, each such second flow channel intersecting multiple of the first flow channels to define intersecting volumes and a plurality of looped flow channels that each include segments of the flow channels between the intersecting volumes to define a closed loop. The microfluidic device also includes a plurality of control valves each such control valve having a control channel and a deformable segment disposed to restrict flow through a respective one of the first and second flow channels in response to an actuation force applied to the control channel to deflect the deformable segment. The microfluidic device further includes a pump operatively disposed to regulate flow through one of the looped flow channels to regulate flow by the recirculating pump.

    MICROFLUIDIC PARTICLE-ANALYSIS SYSTEMS
    8.
    发明专利
    MICROFLUIDIC PARTICLE-ANALYSIS SYSTEMS 未知

    公开(公告)号：CA2480728A1

    公开(公告)日：2003-10-16

    申请号：CA2480728

    申请日：2003-04-01

    Applicant: FLUIDIGM CORP

    Inventor： MANGER IAN D ,  THRONDSET WILLIAM ,  NASSEF HANY RAMEZ ,  NORTON PIERCE ,  FARRELL KEVIN ,  FOWLER BRIAN ,  HAO CUNSHENG CASEY ,  LIAU YISH-HANN ,  JAVADI SHERVIN ,  DARIDON ANTOINE ,  CHOU HOU-PU

    IPC: G01N37/00 ,  B01L3/00 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00 ,  C12N1/00 ,  C12Q1/02 ,  G01N15/02 ,  G01N15/14

    Abstract: The invention provides systems (2000), including microfluidic mechanisms, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. These mechanisms may enable controlle d input, movement/positioning, retention/localization, treatment, measurement, release, and/or output of particles. Furthermore, these mechanisms may be combined in any suitable order and/or employed for any number of suitable times in the system to allow particles to be sorted, cultured, mixed, treate d, and/or assayed, among others. These combinations may allow the response of particles to treatment to be measured on a shorter time scale than was previously possible. Therefore, systems of the invention may allow a broad range of cell and particle assays, such as drug screens, cell characterizations, research studies, and/or clinical analyses, among others, to be scaled down to microfluidic size. Such scaled-down assays may use less sample and reagent, may be less labor intensive, and/or may be more informative than comparable macrofluidic assays.

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