PROCESS FOR THE PREPARATION OF 3-(ACYL)AMINO-4-ALKOXYPHENYL-BETA-HYDROXYETHYL-SULFONE(SULFATES)

    公开(公告)号:IN165318B

    公开(公告)日:1989-09-16

    申请号:IN629CA1985

    申请日:1985-09-02

    Applicant: HOECHST AG

    Abstract: A process for the preparation of 3-(acyl)amino-4-alkoxy-phenyl- beta -hydroxyethyl-sulfone (sulfates) of the formula (1) (1) in which R1 is alkyl having 1-4 carbon atoms and R2 is hydrogen or one of the groupings +TR with the proviso that n=1 if R2=H and n=0 if R2=acyl, by converting 2-alkoxyacylanilines of the formula (2) (2) in which R1 and R2 have the meanings given, in a known manner to the corresponding sulfochlorides substituted in the p-position relative to the alkoxy group, reducing the sulfochlorides with an alkali metal sulfite or ammonium sulfite in an aqueous medium at pH 7.0-8.5 and at -5 to +40 DEG C. to give the corresponding sulfinates, alkoxylating the latter with ethylene oxide in an aqueous medium at pH 6.0-8.5 and 40 DEG -80 DEG C. to give the 3-acylamino-4-alkoxyphenyl- beta -hydroxyethyl-sulfones of the formula (1) (with R2=acyl and n=0) and, if appropriate, esterifying the latter, with deacylation, with concentrated sulfuric acid at 70 DEG -150 DEG C. to give the compounds of the said formula (1) (with R2H and n=1).

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