Abstract:
PROBLEM TO BE SOLVED: To provide a composition and method for detecting an Ehrlichia (Ehrlichia canis and Ehrlichia chaffeensis) antibody and an antibody fragment. SOLUTION: The composition containing an isolated polypeptide selected from the polypeptide group consisting of a specific amino sequence is provided. The method for detecting the antibody to Ehrlichia that includes bringing the polypeptide into contact with a test sample suspected to contain the antibody to Ehrlichia under the condition that a polypeptide/antibody complex be formed is provided. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation:待解决的问题:提供用于检测埃里克氏菌(Ehrlichia canis and Ehrlichia chaffeensis)抗体和抗体片段的组合物和方法。 提供了含有选自特定氨基序列的多肽的分离多肽的组合物。 提供了检测抗体的方法,其包括使多肽与疑似含抗体的测试样品在形成多肽/抗体复合物的条件下接触。 版权所有(C)2009,JPO&INPIT
Abstract:
Disclosed are binding proteins that specifically bind to an isolated and purified peptide comprising a leucine positioned two peptide bonds away from a tyrosine-arginine pair. Other binding proteins of the invention include those that specifically bind to an isolated and purified peptide with the sequence cysteine-blank-blank-proline-histidine-blank-blank-blank-cysteine (SEQ ID NO:6) or cysteine-blank-proline-histidine-blank-proline-blank-blank-cysteine (SEQ ID NO:9).
Abstract:
The invention provides methods and compositions for inhibiting binding of IgE to a high affinity receptor. The methods and compositions are useful in the treatment of allergic diseases and allergy symptoms in mammals.
Abstract:
The invention provides methods and compositions for the detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies and antibody fragments.
Abstract:
The present invention provides for the isolation and characterization of canine interleukin-5 (IL-5) and nucleic acid and amino acid sequences of IL-5. More particularly, recombinant DNA molecules encoding for canine interleukin-5 and conservative variants are provided. In other aspects, the invention provides cells comprising the recombinant vectors, and methods for producing canine IL-5 comprising the steps of inserting a transcription regulatory sequence proximal to the IL-5 gene in a cell comprising that gene, and stimulating production of IL-5 through the regulatory sequence.
Abstract:
The invention provides methods and compositions for inhibiting binding of IgE to a high affinity receptor. The methods and compositions are useful in the treatment of allergic diseases and allergy symptoms in mammals.
Abstract:
The present invention features methods for identifying peptides that selectively bind to PrP Sc or fragments thereof. The invention also features the use of such peptides in screening methods for the identification of candidate agents useful for the treatment of a prion disease.