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公开(公告)号：WO0111049A2
公开(公告)日：2001-02-15
申请号：PCT/US0021651
申请日：2000-08-09
Applicant: IDEXX LAB INC , GUO HONGLIANG , LAWTON ROBERT , MERMER BRION , AIYAPPA ASHOK P
Inventor： GUO HONGLIANG , LAWTON ROBERT , MERMER BRION , AIYAPPA ASHOK P
IPC: A61K38/00 , A61K39/00 , C07K14/54 , C07K16/24 , C12N15/24 , A61K38/20 , A61K39/395 , C12N5/10 , C12N15/11 , G01N33/68
CPC classification number: C07K16/244 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/5409
Abstract: The present invention provides for the isolation and characterization of canine interleukin-5 (IL-5) and nucleic acid and amino acid sequences of IL-5. More particularly, recombinant DNA molecules encoding for canine interleukin-5 and conservative variants are provided. In other aspects, the invention provides cells comprising the recombinant vectors, and methods for producing canine IL-5 comprising the steps of inserting a transcription regulatory sequence proximal to the IL-5 gene in a cell comprising that gene, and stimulating production of IL-5 through the regulatory sequence.
Abstract translation: 本发明提供了白介素-5（IL-5）和IL-5的核酸和氨基酸序列的分离和表征。 更具体地，提供了编码犬白介素-5和保守变体的重组DNA分子。 在其他方面，本发明提供了包含重组载体的细胞，以及用于产生犬IL-5的方法，其包括以下步骤：将包含该基因的细胞中的IL-5基因的接近的转录调节序列插入，并刺激IL- 5通过调节序列。
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2.发明公开CANINE IMMUNOGLOBULIN VARIABLE DOMAINS, CANINIZED ANTIBODIES, AND METHODS FOR MAKING AND USING THEM 审中-公开DOG免疫球蛋白可变区，狗喜欢抗体及其制备方法和用途
公开(公告)号：EP1485126A4
公开(公告)日：2007-03-21
申请号：EP02794415
申请日：2002-12-20
Applicant: IDEXX LAB INC
Inventor： KRAH EUGENE REGIS III , GUO HONGLIANG , AIYAPPA ASHOK , LAWTON ROBERT
IPC: C12N15/09 , A61K39/395 , A61P37/08 , A61P43/00 , C07K16/18 , C07K16/42 , C07K19/00 , C07K16/00 , C12N15/00
CPC classification number: C07K16/4291 , A61K2039/505 , C07K2317/20 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2319/00
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3.发明专利
公开(公告)号：AU2002359851A8
公开(公告)日：2003-07-30
申请号：AU2002359851
申请日：2002-12-20
Applicant: IDEXX LAB INC
Inventor： KRAH EUGENE REGIS III , LAWTON ROBERT , GUO HONGLIANG , AIYAPPA ASHOK
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公开(公告)号：DE60127237D1
公开(公告)日：2007-04-26
申请号：DE60127237
申请日：2001-01-30
Applicant: IDEXX LAB INC
Inventor： LAWTON ROBERT L , AIYAPPA ASHOK P , LIU WENDY W , MERMER BRION , GUO HONGLIANG , KRAH EUGENE R
Abstract: The present invention provides methods and compositions for decreasing IgE levels in dogs. The methods and compositions are useful for treating allergic symptoms in dogs. The invention may comprise chimeric canine anti-IgE monoclonal antibody compositions and methods for using the compositions in the treatment of allergy. In preferred embodiments, the compositions of the present invention may act by binding soluble IgE in plasma, or by inhibiting IgE from binding to receptors on mast cells, B cells, and basophils.
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公开(公告)号：AU3310201A
公开(公告)日：2001-08-14
申请号：AU3310201
申请日：2001-01-30
Applicant: IDEXX LAB INC
Inventor： LAWTON ROBERT L , AIYAPPA ASHOK P , LIU WENDY W , MERMER BRION , GUO HONGLIANG , KRAH EUGENE R III
Abstract: The present invention provides methods and compositions for decreasing IgE levels in dogs. The methods and compositions are useful for treating allergic symptoms in dogs. The invention may comprise chimeric canine anti-IgE monoclonal antibody compositions and methods for using the compositions in the treatment of allergy. In preferred embodiments, the compositions of the present invention may act by binding soluble IgE in plasma, or by inhibiting IgE from binding to receptors on mast cells, B cells, and basophils.
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Patent Agency Ranking
公开(公告)号：DE60127237T2
公开(公告)日：2007-12-20
申请号：DE60127237
申请日：2001-01-30
Applicant: IDEXX LAB INC
Inventor： LAWTON ROBERT L , AIYAPPA ASHOK P , LIU WENDY W , MERMER BRION , GUO HONGLIANG , KRAH EUGENE R
Abstract: The present invention provides methods and compositions for decreasing IgE levels in dogs. The methods and compositions are useful for treating allergic symptoms in dogs. The invention may comprise chimeric canine anti-IgE monoclonal antibody compositions and methods for using the compositions in the treatment of allergy. In preferred embodiments, the compositions of the present invention may act by binding soluble IgE in plasma, or by inhibiting IgE from binding to receptors on mast cells, B cells, and basophils.
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7.发明专利
公开(公告)号：AU2002359851A1
公开(公告)日：2003-07-30
申请号：AU2002359851
申请日：2002-12-20
Applicant: IDEXX LAB INC
Inventor： KRAH EUGENE REGIS III , GUO HONGLIANG , AIYAPPA ASHOK , LAWTON ROBERT
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8.发明专利
公开(公告)号：CA2469833A1
公开(公告)日：2003-07-24
申请号：CA2469833
申请日：2002-12-20
Applicant: IDEXX LAB INC
Inventor： LAWTON ROBERT , KRAH EUGENE REGIS III , GUO HONGLIANG , AIYAPPA ASHOK
IPC: C12N15/09 , A61K39/395 , A61P37/08 , A61P43/00 , C07K16/18 , C07K16/42 , C07K19/00 , C07K16/00 , C12N15/00
Abstract: The present invention provides canine heavy chain and light chain (both .lambda. and .kappa.) variable domain nucleic acids and polypeptides. The present invention also provides caninized antibodies comprised of the presen t disclosed canine variable domain framework sequences and CDRs specific for a n antigen obtained from antibodies from other than canines (preferably mouse). The invention also provides methods of making caninized antibodies and using them. This disclosure specifically describes caninized antibodies that are useful in the treatment of canine allergy. The general process of caninizati on permits the development of useful therapeutics, which includes but is not limited to allergy, osteoarcomma's and lymphomma's.
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9.发明专利
公开(公告)号：CA2469833C
公开(公告)日：2008-05-20
申请号：CA2469833
申请日：2002-12-20
Applicant: IDEXX LAB INC
Inventor： LAWTON ROBERT , KRAH EUGENE REGIS III , AIYAPPA ASHOK , GUO HONGLIANG
IPC: C12N15/09 , C12N15/13 , A61K39/395 , A61P37/08 , A61P43/00 , C07K16/00 , C07K16/18 , C07K16/42 , C07K16/46 , C07K19/00
Abstract: The present invention provides canine heavy chain and light chain (both .lambda. and .kappa.) variable domain nucleic acids and polypeptides. The present invention also provides caninized antibodies comprised of the presen t disclosed canine variable domain framework sequences and CDRs specific for a n antigen obtained from antibodies from other than canines (preferably mouse). The invention also provides methods of making caninized antibodies and using them. This disclosure specifically describes caninized antibodies that are useful in the treatment of canine allergy. The general process of caninizati on permits the development of useful therapeutics, which includes but is not limited to allergy, osteoarcomma's and lymphomma's.
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公开(公告)号：AU6401800A
公开(公告)日：2001-03-05
申请号：AU6401800
申请日：2000-08-09
Applicant: IDEXX LAB INC
Inventor： GUO HONGLIANG , LAWTON ROBERT , MERMER BRION , AIYAPPA ASHOK P
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