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公开(公告)号：WO2021170786A1
公开(公告)日：2021-09-02
申请号：PCT/EP2021/054801
申请日：2021-02-26
Applicant: INTERNA TECHNOLOGIES B.V.
Inventor： YAHYANEJAD, Sanaz , TELFORD, Bryony , VAN DEN BOSCH, Marion , ALEMDEHY, Mir Farshid , DE GUNST, Matheus Maria , VAN PINXTEREN, Laurens Adrianus Hendricus , SCHAAPVELD, Roeland Quirinus Jozef , JANICOT, Michel
IPC: C12N15/113
Abstract: The invention relates to the use of miRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a CRT agonist, promoting the cell surface expression of CRT. This allows the advantageous treatment of cancers without or with low surface expression of CRT. The invention further relates to compositions comprising the miRNA for use in such treatment.
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公开(公告)号：WO2021028081A1
公开(公告)日：2021-02-18
申请号：PCT/EP2020/055965
申请日：2020-03-06
Applicant: INTERNA TECHNOLOGIES B.V.
Inventor： YAHYANEJAD, Sanaz , TELFORD, Bryony , VAN DEN BOSCH, Marion , ALEMDEHY, Mir Farshid , DE GUNST, Matheus Maria , VAN PINXTEREN, Laurens Adrianus Hendricus , SCHAAPVELD, Roeland Quirinus Jozef , JANICOT, Michel
IPC: C12N15/113
Abstract: The invention relates to the use ofmiRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a PTEN agonist. This allows the advantageous treatment of PTEN- deficient cancers. The invention further relates to compositions comprising the miRNA for use as a PTEN agonist.
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Patent Agency Ranking3.发明申请COMBINATION FOR USE IN TREATING DISEASES OR CONDITIONS ASSOCIATED WITH MELANOMA, OR TREATING DISEASES OR CONDITIONS ASSOCIATED WITH ACTIVATED B-RAF PATHWAY 审中-公开用于治疗与MELANOMA相关的疾病或病症的组合或治疗与激活的B-RAF途径相关的疾病或病症
公开(公告)号：WO2014072357A1
公开(公告)日：2014-05-15
申请号：PCT/EP2013/073192
申请日：2013-11-06
Applicant: INTERNA TECHNOLOGIES B.V.
Inventor： VAN HAASTERT, Rick Jan , VAN NOORT, Petronella Innocentia , PREVOST, Grégoire Pierre André , GOMMANS, Willemijn Maria , SCHAAPVELD, Roeland Quirinus Jozef , DE GUNST, Matheus Maria , SCHULTZ, Iman Johannes , BEREZIKOV, Eugene
IPC: C12N15/113 , A61P35/00 , A61K31/713
CPC classification number: A61K31/713 , A61K31/4184 , A61K31/437 , A61K31/506 , A61K31/519 , C12N15/1135 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12N2320/31 , C12N2330/10 , A61K2300/00
Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
Abstract translation: 本发明涉及在与黑素瘤或与活化的BRAF途径相关的疾病或病症相关的疾病和病症中的组合的治疗用途。
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公开(公告)号：EP3800256A1
公开(公告)日：2021-04-07
申请号：EP20190754.0
申请日：2013-11-06
Applicant: InteRNA Technologies B.V.
Inventor： VAN HAASTERT, Rick Jan , VAN NOORT, Petronella Innocentia , PREVOST, Grégoire Pierre André , GOMMANS, Willemijn Maria , SCHAAPVELD, Roeland Quirinus Jozef , DE GUNST, Matheus Maria , SCHULTZ, Iman Johannes , BEREZIKOV, Eugene
IPC: C12N15/113 , A61P35/00 , A61K31/713 , A61K31/4184 , A61K31/437 , A61K31/506 , A61K31/519
Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
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公开(公告)号：EP4110917A1
公开(公告)日：2023-01-04
申请号：EP21706991.3
申请日：2021-02-26
Applicant: InteRNA Technologies B.V.
Inventor： YAHYANEJAD, Sanaz , TELFORD, Bryony , VAN DEN BOSCH, Marion , ALEMDEHY, Mir Farshid , DE GUNST, Matheus Maria , VAN PINXTEREN, Laurens Adrianus Hendricus , SCHAAPVELD, Roeland Quirinus Jozef , JANICOT, Michel
IPC: C12N15/113
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公开(公告)号：EP4013869A1
公开(公告)日：2022-06-22
申请号：EP20707290.1
申请日：2020-03-06
Applicant: InteRNA Technologies B.V.
Inventor： YAHYANEJAD, Sanaz , TELFORD, Bryony Jane , VAN DEN BOSCH, Marion Tina Jolien , ALEMDEHY, Mir Farshid , DE GUNST, Matheus Maria , VAN PINXTEREN, Laurens Adrianus Hendricus , SCHAAPVELD, Roeland Quirinus Jozef , JANICOT, Michel
IPC: C12N15/113
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7.发明公开COMBINATION FOR USE IN TREATING DISEASES OR CONDITIONS ASSOCIATED WITH MELANOMA, OR TREATING DISEASES OR CONDITIONS ASSOCIATED WITH ACTIVATED B-RAF PATHWAY 审中-公开融合对患有黑色素瘤或与其相关的疾病和病症的治疗有关的疾病或病症的治疗激活的B-RAF信号
公开(公告)号：EP2917348A1
公开(公告)日：2015-09-16
申请号：EP13788743.6
申请日：2013-11-06
Applicant: InteRNA Technologies B.V.
Inventor： VAN HAASTERT, Rick Jan , VAN NOORT, Petronella Innocentia , PREVOST, Grégoire Pierre André , GOMMANS, Willemijn Maria , SCHAAPVELD, Roeland Quirinus Jozef , DE GUNST, Matheus Maria , SCHULTZ, Iman Johannes , BEREZIKOV, Eugene
IPC: C12N15/113 , A61P35/00 , A61K31/713
CPC classification number: A61K31/713 , A61K31/4184 , A61K31/437 , A61K31/506 , A61K31/519 , C12N15/1135 , C12N2310/113 , C12N2310/141 , C12N2320/10 , C12N2320/31 , C12N2330/10 , A61K2300/00
Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
Abstract translation: 本发明涉及与黑素瘤或疾病或与活化的BRAF途径相关的病症有关的疾病和病症的治疗用途的组合。
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