公开(公告)号：DE10251345A1

公开(公告)日：2004-05-19

申请号：DE10251345

申请日：2002-11-05

Applicant: LEICA MICROSYSTEMS

Inventor： HOPPE MARTIN ,  KNEBEL WERNER ,  MOELLMANN KYRA ,  STORZ RAFAEL

IPC: G02B21/24 ,  A61B5/00 ,  A61B5/02

Abstract: The invention concerns a method and an apparatus for investigating layers ( 1 ) of tissues in living animals using a microscope ( 2 ). The microscope ( 2 ) is focused onto a layer ( 1 ), and images of the layer ( 1 ) are acquired or optical measurements are performed on it. Positional changes of the layer ( 1 ) are brought about by movements of the animal or of its organs. The positional changes are sensed, and corresponding signals are generated. The signals are stored, together with the corresponding images or measurement results, for later evaluation; or they are processed in such a way that the positional changes are compensated for in order to investigate the layer ( 1 ). As a result, the layer ( 1 ) can be qualitatively or quantitatively investigated microscopically, irrespective of the movement of the animal or its organs.

公开(公告)号：DE10251345B4

公开(公告)日：2006-08-17

申请号：DE10251345

申请日：2002-11-05

Applicant: LEICA MICROSYSTEMS

Inventor： HOPPE MARTIN ,  KNEBEL WERNER ,  MOELLMANN KYRA ,  STORZ RAFAEL

IPC: A61B5/00 ,  A61B5/02 ,  G02B21/24

Abstract: The invention concerns a method and an apparatus for investigating layers ( 1 ) of tissues in living animals using a microscope ( 2 ). The microscope ( 2 ) is focused onto a layer ( 1 ), and images of the layer ( 1 ) are acquired or optical measurements are performed on it. Positional changes of the layer ( 1 ) are brought about by movements of the animal or of its organs. The positional changes are sensed, and corresponding signals are generated. The signals are stored, together with the corresponding images or measurement results, for later evaluation; or they are processed in such a way that the positional changes are compensated for in order to investigate the layer ( 1 ). As a result, the layer ( 1 ) can be qualitatively or quantitatively investigated microscopically, irrespective of the movement of the animal or its organs.

公开(公告)号：DE59709530D1

公开(公告)日：2003-04-24

申请号：DE59709530

申请日：1997-12-20

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN ,  HOPPE MARTIN

IPC: G02B21/00 ,  G02B21/36 ,  H04N5/225 ,  H04N9/04

Abstract: A TV camera for microscopic or macroscopic imaging is characterized by a confocal lens with a laser light source (1), a scanner (2), a detector (3) and an electronic control unit (4), for using confocal characteristics in the most compact possible format.

公开(公告)号：DE19901219A1

公开(公告)日：1999-09-09

申请号：DE19901219

申请日：1999-01-14

Applicant: LEICA MICROSYSTEMS

Inventor： ENGELHARDT JOHANN ,  HOPPE MARTIN ,  ULRICH HEINRICH

IPC: G02B21/00 ,  G02B21/08 ,  G02B21/06

Abstract: The arrangement has an illumination lens system for varying the illumination dia. (7) arranged in the illumination light path (1). The illumination lens system (6) consists of an arrangement of interchangeable fixed lenses or a pref. continuously adjustable lens, e.g. a motorised zoom lens An Independent claim is also included for an application of the arrangement to multiple photon laser scanning microscopy.