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公开(公告)号：WO2016094512A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/064700
申请日：2015-12-09
Applicant: yLIFE TECHNOLOGIES CORPORATION , THERMO FISHER SCIENTIFIC GENEART GMBH , LIFE TECHNOLOGIES AS
Inventor： POEHMERER, Thomas , KUHN, Phillip , NOTKA, Frank , ZEIDLER, Andreas , HEIL, Korbinian , TREFZER, Axel , FONNUM, Geir , KATZEN, Federico , ANDERSSON, Kristian , LIANG, Xiquan
CPC classification number: C12N15/101 , B01J2219/00468 , B01J2219/005 , B01J2219/00653 , B01J2219/00695 , B01J2219/00722 , B01L3/502715 , B01L3/502761 , B01L2200/0642 , B01L2200/0647 , B01L2300/0819 , B01L2300/0893 , B01L2400/046 , B01L2400/0487 , B03C5/026 , B03C2201/26 , C25B3/10 , C25B9/18 , C25B11/04 , C25B15/02
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
Abstract translation: 本公开一般涉及用于生产核酸分子的组合物和方法。 在一些方面，本发明允许核酸分子的微量生成，任选地随后将这些核酸分子装配到更大的分子中。 在一些方面，本发明允许有效生产核酸分子（例如，大的核酸分子，例如基因组）。
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公开(公告)号：WO2023079524A2
公开(公告)日：2023-05-11
申请号：PCT/IB2022/060693
申请日：2022-11-07
Applicant: LIFE TECHNOLOGIES AS
Inventor： OOI, Huey Wen , LUNDBERG, Pontus , BOESCHEN, Maxi-Lu , ALMAASBAK, Hilde , HERENG, Tuva Holt , STAV-NORAAS, Tor-Espen , LANDSVERK, Ole , FONNUM, Geir
Abstract: The invention relates to polymer-interaction molecule (e.g., antibodies) conjugates and uses of such conjugates for delivery of interaction molecules to cells. The invention also relates uses polymer-interaction molecule (e.g., antibodies) conjugates for eliciting cellular responses (e.g., induction of cell proliferation).
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公开(公告)号：WO2017211913A1
公开(公告)日：2017-12-14
申请号：PCT/EP2017/063879
申请日：2017-06-07
Inventor： ANDERSSON, Kristian , FONNUM, Geir , HEIL, Korbinian
IPC: C08F212/08 , C08F220/58
Abstract: This invention relates to polymer particles for solid phase oligonucleotide synthesis. The oligonucleotide may be linked to the particle via a linker having an amide- oligoethyleneglycol-amine structure. The particles may be considered to act as a solid support during the oligonucleotide synthesis. Also disclosed are processes for preparing such polymer particles, compositions and systems comprising such particles, and uses thereof.
Abstract translation: 本发明涉及用于固相寡核苷酸合成的聚合物颗粒。 寡核苷酸可以通过具有酰胺 - 寡聚乙二醇 - 胺结构的接头连接至颗粒。 在寡核苷酸合成过程中，可以认为颗粒充当固体支持物。 还公开了用于制备这种聚合物颗粒的方法，包含这种颗粒的组合物和系统及其用途。
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公开(公告)号：WO2017013138A8
公开(公告)日：2017-01-26
申请号：PCT/EP2016/067218
申请日：2016-07-19
Applicant: LIFE TECHNOLOGIES AS
Inventor： FONNUM, Geir , LUNDBERG, Per, Nils, Pontus, , GÖKMEN, Muhammed, Talha , LARSEN, Synne , GLOMM, Wilhelm , JOHNSEN, Heidi , SCHMID, Ruth , KILAAS, Lars
IPC: C08F120/54 , C08F2/38 , C08F265/10
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non- crosslinked oligomers of poly Ν,Ν-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
Abstract translation: 本发明涉及单分散交联水凝胶聚合物颗粒，其包含由（a）亲水性乙烯基单体形成的聚合物; 和（b）包含至少两个乙烯基的交联剂。 本发明还涉及包含多个N，N-二甲基丙烯酰胺的非交联低聚物的Z-平均直径为100nm至1500nm的单分散种子颗粒。 还提供了形成单分散交联水凝胶聚合物颗粒和单分散种子颗粒的方法。
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公开(公告)号：WO2017013138A1
公开(公告)日：2017-01-26
申请号：PCT/EP2016/067218
申请日：2016-07-19
Applicant: LIFE TECHNOLOGIES AS
Inventor： FONNUM, Geir , LUNDBERG, Per, Nils, Pontus, , GÖKMEN, Muhammed, Talha , LARSEN, Synne , GLOMM, Wilhelm , JOHNSEN, Heidi , SCHMID, Ruth , KILAAS, Lars
IPC: C08F120/54 , C08F2/38 , C08F265/10
CPC classification number: C08F120/54 , C08F265/10 , C08F220/56
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non- crosslinked oligomers of poly Ν,Ν-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
Abstract translation: 本发明涉及包含由（a）亲水性乙烯基单体形成的聚合物的单分散交联水凝胶聚合物颗粒; 和（b）包含至少两个乙烯基的交联剂。 本发明还涉及Z平均直径为100nm至1500nm的单分散种子颗粒，其包含多个未交联的聚N，N-二甲基丙烯酰胺的低聚物。 还提供了形成单分散交联水凝胶聚合物颗粒和单分散种子颗粒的方法。
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Patent Agency Ranking
公开(公告)号：WO2017004559A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/040767
申请日：2016-07-01
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： FONNUM, Geir , MENCHEN, Steven M. , LUI, Alfred , XIANG, Guobing , LARSEN, Synne
IPC: C12Q1/68 , G01N33/543
CPC classification number: C12Q1/6876 , C12Q1/6869 , C12Q1/6874 , C12Q2525/197 , C12Q2527/125 , C12Q2565/607 , C12Q2565/629
Abstract: A polymer substrate, such as a polymer coating or a polymer hydrogel network, includes carboxyl moieties that can be used as conjugation sites to which receptor or analyte molecules can be attached. In an example, the polymer substrate includes a polyacrylamide polymer network having alkanoic acid moieties or derivatives thereof, which can react with carboxyl activating compounds to provide an activated alkanoate moieties on the polyacrylamide network. Amine-terminated nucleic acids can react with the activated alkanoate moieties to capture the nucleic acid to the polymer network through an alkylamide moiety.
Abstract translation: 聚合物基质，例如聚合物涂层或聚合物水凝胶网络，包括羧基部分，其可以用作受体或分析物分子可以连接到的缀合位点。 在一个实例中，聚合物底物包括具有链烷酸部分或其衍生物的聚丙烯酰胺聚合物网络，其可与羧基活化化合物反应，以在聚丙烯酰胺网络上提供活化的链烷酸酯部分。 胺封端的核酸可以与活化的链烷酸酯部分反应，以通过烷基酰胺部分将核酸捕获到聚合物网络。
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公开(公告)号：WO2017004556A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/040755
申请日：2016-07-01
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： FONNUM, Geir , MENCHEN, Steven, M. , GOKMEN, Talha, M. , LUNDBERG, Pontus , THWAR, Prasanna Krishnan , LUI, Alfred , LU, Lily , HINZ, Wolfgang , HUSABOE, Lene , BREIVOLD, Elisabeth , MOLTEBERG, Astrid, Evenroed , LARSEN, Synne
IPC: C08F220/58 , C08F8/12
CPC classification number: C08J3/075 , C08F8/12 , C08F220/58 , C08F220/70 , C08F2230/085 , C08J2333/26 , C08F222/38
Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
Abstract translation: 聚合物基材如聚合物颗粒由羧基官能单体形成。 在一个实例中，羧基官能单体具有保护基代替羧基的OH。 一旦单体聚合，就可以除去这种保护基团，从而提供具有羧基官能位点的聚合物网络。 这种位点可用于将其它功能性附加到聚合物基材上。
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公开(公告)号：EP4430076A2
公开(公告)日：2024-09-18
申请号：EP22822211.3
申请日：2022-11-07
Applicant: Life Technologies AS
Inventor： OOI, Huey Wen , LUNDBERG, Pontus , BOESCHEN, Maxi-Lu , ALMAASBAK, Hilde , HERENG, Tuva Holt , STAV-NORAAS, Tor-Espen , LANDSVERK, Ole , FONNUM, Geir
CPC classification number: C07K16/2809 , C07K16/2818 , A61K47/595 , C08G73/0233 , C08G63/91 , C08G83/004 , C08G83/007
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公开(公告)号：EP3317314B1
公开(公告)日：2020-01-08
申请号：EP16741201.4
申请日：2016-07-01
Applicant: Life Technologies Corporation , Life Technologies AS
Inventor： FONNUM, Geir , MENCHEN, Steven, M. , GOKMEN, Talha, M. , LUNDBERG, Pontus , THWAR, Prasanna Krishnan , LUI, Alfred , LU, Lily , HINZ, Wolfgang , HUSABOE, Lene , BREIVOLD, Elisabeth , MOLTEBERG, Astrid, Evenroed , LARSEN, Synne
IPC: C08F220/58 , C08F8/12
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公开(公告)号：EP3469009A1
公开(公告)日：2019-04-17
申请号：EP17730104.1
申请日：2017-06-07
Inventor： ANDERSSON, Kristian , FONNUM, Geir , HEIL, Korbinian
IPC: C08F212/08 , C08F220/58
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