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    Methine-Substituted Cyanine Dye Compounds
    1.
    发明申请
    Methine-Substituted Cyanine Dye Compounds 有权
    甲基取代的Cyanine染料化合物

    公开(公告)号：US20150191600A1

    公开(公告)日：2015-07-09

    申请号：US14662397

    申请日：2015-03-19

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jason DALLWIG ,  David HAGEN ,  Ching-Ying CHEUNG ,  Gerald THOMAS ,  Stephen YUE

    IPC: C09B23/10 ,  C09B23/06 ,  C12Q1/68 ,  C09B23/04

    CPC classification number: C09B23/164 ,  C07D277/64 ,  C07D417/06 ,  C09B23/0008 ,  C09B23/04 ,  C09B23/06 ,  C09B23/107 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q2600/16 ,  G01N33/5308 ,  Y10T436/143333

    Abstract: Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.

    Abstract translation: 具有作为核酸染色的取代的次甲基部分的花青染料化合物，特别是用于RNA的荧光染色，包括具有下式的化合物，其中R 1是C 1 -C 6烷基，磺基烷基，羧基烷基或C 1 -C 6烷氧基; 每个R 2独立地选自H，C 1 -C 6烷基，C 1 -C 6烷氧基，稠合的苯并，三氟甲基，氨基，磺基，羧基和卤素，其任选进一步被取代; R 3，R 4和R 5中的至少一个是任选被烷基，氨基，氨基烷基，羧基，硝基或卤素取代的烷基，芳基，杂芳基，环状或杂环部分; 剩余的R3，R4或R5是氢; X是S，O或Se; 并且D是取代或未取代的吡啶鎓，喹啉鎓或苯并咪唑鎓部分。

    DETECTION AND QUANTIFICATION OF NUCLEIC ACID MOLECULES ASSOCIATED WITH A SURFACE
    2.
    发明申请
    DETECTION AND QUANTIFICATION OF NUCLEIC ACID MOLECULES ASSOCIATED WITH A SURFACE 审中-公开

    公开(公告)号：US20180363037A1

    公开(公告)日：2018-12-20

    申请号：US15781899

    申请日：2016-12-07

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  THERMO FISHER SCIENTIFIC GENEART GMBH

    Inventor： Korbinian HEIL ,  Frank NOTKA ,  Kyle GEE ,  Jason DALLWIG ,  Phillip KUHN ,  Schuyler CORRY

    IPC: C12Q1/6834

    Abstract: This disclosure relates to methods, compositions, and related apparatuses for detection and quantification of nucleic acid molecules associated with a solid surface. Methods can include detecting or quantifying at least one nucleic acid molecule associated with a surface by contacting the at least one nucleic acid molecule with a fluorophore, wherein the fluorophore emits increased fluorescence at a wavelength when in contact with nucleic acid molecule, and detecting or measuring fluorescence from the fluorophore at the wavelength. Compositions can comprise a fluorophore and a nucleic acid molecule, wherein the nucleic acid molecule is associated with a surface, and the fluorophore has the property of emitting increased fluorescence at a wavelength when in contact with a nucleic acid molecule.

    Methine-Substituted Cyanine Dye Compounds
    3.
    发明申请
    Methine-Substituted Cyanine Dye Compounds 有权
    甲基取代的Cyanine染料化合物

    公开(公告)号：US20160304719A1

    公开(公告)日：2016-10-20

    申请号：US15194911

    申请日：2016-06-28

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jason DALLWIG ,  David HAGEN ,  Ching-Ying CHEUNG ,  Gerald THOMAS ,  Stephen YUE

    IPC: C09B23/16 ,  C07D417/06 ,  C12Q1/68 ,  C07D277/64

    CPC classification number: C09B23/164 ,  C07D277/64 ,  C07D417/06 ,  C09B23/0008 ,  C09B23/04 ,  C09B23/06 ,  C09B23/107 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q2600/16 ,  G01N33/5308 ,  Y10T436/143333

    Abstract: Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.

    Abstract translation: 其中R 1是C 1 -C 6烷基，磺基烷基，羧基烷基或C 1 -C 6烷氧基; 每个R 2独立地选自H，C 1 -C 6烷基，C 1 -C 6烷氧基，稠合的苯并，三氟甲基，氨基，磺基，羧基和卤素，其任选进一步被取代; R 3，R 4和R 5中的至少一个是任选被烷基，氨基，氨基烷基，羧基，硝基或卤素取代的烷基，芳基，杂芳基，环状或杂环部分; 剩余的R3，R4或R5是氢; X是S，O或Se; 并且D是取代或未取代的吡啶鎓，喹啉鎓或苯并咪唑鎓部分。

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