公开(公告)号：US3652552A

公开(公告)日：1972-03-28

申请号：US3652552D

申请日：1967-12-18

Applicant: STAMICARBON

Inventor： GARRITSEN JOHAN W ,  HOFMAN JOHANNES H A

IPC: C07D201/10 ,  C07D29/16

CPC classification number: C07D201/10

Abstract: A PROCESS FOR PRODUCING LACTAMS FROM CYCLOALKANES IS DISCLOSED. CYCLOALKANES ARE REACTED WITH NITROSYL CHLORIDE WHILE SUBJECTED TO IRRADIATION, IN THE PRESENCE OF A NITRILE WHICH DOES NOT CONTAIN ANY METHYLENE GROUPS CAPABLE OF REACTING WITH NITROSYL UNDER THE REACTION CONDITIONS. WLACTAMS ARE DIRECTLY PRODUCED BY HEATING THE REACTION PRODUCT.

公开(公告)号：CA865161A

公开(公告)日：1971-03-02

申请号：CA865161D

Applicant: STAMICARBON

Inventor： GARRITSEN JOHAN W ,  HOFMAN JOHANNES H A

公开(公告)号：CA1123005A

公开(公告)日：1982-05-04

申请号：CA185651

申请日：1973-11-13

Applicant: STAMICARBON

Inventor： SCHAAFSMA SIJBRANDUS E ,  HOFMAN JOHANNES H A ,  CLAASSENS JOHANNES E L

IPC: C07C69/716 ,  B01J31/00 ,  C07B61/00 ,  C07C20060101 ,  C07C67/313 ,  C07C67/347 ,  C07C69/66 ,  C07C69/73 ,  C07C69/74

Abstract: Delta-keto-esters such as 4-oxopentane-1-carboxylic acid methyl ester and the like, are prepared in the presence of a primary amine, a Schiff base, or both, by reacting a ketone having at least one hydrogen atom in the alpha position and an alpha-beta unsaturated carboxylic acid ester in the presence of an acid according to the disclosed invention.

公开(公告)号：CA1209996A

公开(公告)日：1986-08-19

申请号：CA415988

申请日：1982-11-19

Applicant: STAMICARBON

Inventor： CORVERS ANTONIUS ,  HOFMAN JOHANNES H A

IPC: A61K31/505 ,  A61P1/08 ,  A61P9/12 ,  A61P25/00 ,  A61P25/04 ,  A61P25/20 ,  A61P25/26 ,  A61P33/10 ,  A61P37/08 ,  A61P43/00 ,  C07D471/08

Abstract: Disclosed are diazabicyclo (2,2,2,) octadiones having the formula: I wherein R1-R6 are independently selected from the group consisting of hydrogen, methyl, and ethyl, which are prepared by: A. reacting a compound having the formula: II wherein R and R' are independently selected from the group consisting of hydrogen and alkyl or cyclo alkyl having 1 to 10 carbon atoms, and R1-R6 are independently selected from the group consisting of hydrogen, methyl, and ethyl, with B. a reactant selected from the group consisting of ammonia and primary amines having the formula R2-NH2 wherein R2 is selected from the group consisting of hydrogen, methyl, and ethyl, The compounds of formula I are useful in preparing the corresponding octanes which are in turn useful as inter alia antihistamines, sedatives and antibiotics.

公开(公告)号：CA865160A

公开(公告)日：1971-03-02

申请号：CA865160D

Applicant: STAMICARBON

Inventor： GARRITSEN JOHAN W ,  HOFMAN JOHANNES H A