公开(公告)号：EP1417153A4

公开(公告)日：2005-01-05

申请号：EP02756424

申请日：2002-07-09

Applicant: STANFORD RES INST INT

Inventor： BOTTARO JEFFREY C ,  PETRIE MARK A ,  PENWELL PAUL E ,  BOMBERGER DAVID C

IPC: A01N25/02 ,  A01N43/70 ,  A01N59/00 ,  A61K47/02 ,  A61K47/04 ,  A61K47/18 ,  A61K47/22 ,  A61K47/32 ,  A61K47/48 ,  A61K49/00 ,  C07C211/32 ,  C07D453/04 ,  C01B21/20 ,  C07C243/00

CPC classification number: C07D453/04 ,  A01N25/02 ,  A61K47/02 ,  A61K47/52 ,  C07C211/32 ,  C07C2603/32

公开(公告)号：CA2059654C

公开(公告)日：1998-06-16

申请号：CA2059654

申请日：1991-06-14

Applicant: STANFORD RES INST INT

Inventor： BOTTARO JEFFREY C ,  SCHMITT ROBERT J ,  PENWELL PAUL E ,  ROSS DAVID S

IPC: C01B21/082 ,  C06B25/00 ,  C06B31/00 ,  C06B41/00 ,  C07C243/02 ,  C07C279/02 ,  C07C281/16 ,  C01B21/20

Abstract: A N,N-dinitramide salt is disclosed having the formula MN(NO2)2 where M is a cat ion selected from the class consisting of a metal ion and a nitrogen-containing ion. The dinitramide salt exhibits high temperature stability, high energy density, and an absence of smoke generating halogens, rendering it useful as an oxidizer in rocket fuels. The dinitramide salts are meltable and pumpable oxidizers which may be used in start-stop rocket engines i nstead of other less stable oxidizers.

公开(公告)号：CA2453179A1

公开(公告)日：2003-01-23

申请号：CA2453179

申请日：2002-07-09

Applicant: STANFORD RES INST INT

Inventor： BOTTARO JEFFREY C ,  PETRIE MARK A ,  PENWELL PAUL E ,  BOMBERGER DAVID C

IPC: A01N25/02 ,  A01N43/70 ,  A01N59/00 ,  A61K47/02 ,  A61K47/04 ,  A61K47/18 ,  A61K47/22 ,  A61K47/32 ,  A61K47/48 ,  A61K49/00 ,  C07C211/32 ,  C07D453/04 ,  C07C243/00 ,  A61K31/16 ,  C07C243/02

Abstract: A method is provided for enhancing the solubility of an ionizable compound i n a lipophilic medium by admixing the compound with an effective solubility- enhancing amount of an N,N-dinitramide salt. The ionizable compound, upon ionization, gives rise to a biologically active cationic species that ionically associates with the N,N-dinitramide anion N(NO2)2 following admixture with the N,N-dinitramide salt. The biologically active cationic species may be a pharmacologically active cation, in which case the method i s useful for enhancing the penetration of the blood-brain barrier by the pharmacologically active cation. In other embodiments, the ionizable compoun ds are medical imaging or diagnostic agents, or agricultural agents such as pesticides. Salts of biologically active cations and N,N-dinitramide ion are also provided as novel compositions of matter.

公开(公告)号：CA2059654A1

公开(公告)日：1991-12-19

申请号：CA2059654

申请日：1991-06-14

Applicant: STANFORD RES INST INT

Inventor： BOTTARO JEFFREY C ,  SCHMITT ROBERT J ,  PENWELL PAUL E ,  ROSS DAVID S

IPC: C01B21/082 ,  C06B25/00 ,  C06B31/00 ,  C06B41/00

Abstract: A N,N-dinitramide salt is disclosed having the formula MN(NO2)2 where M is a cation selected from the class consisting of a metal ion and a nitrogen-containing ion. The dinitramide salt exhibits high temperature stability, high energy density, and an absence of smoke generating halogens, rendering it useful as an oxidizer in rocket fuels. The dinitramide salts are meltable and pumpable oxidizers which may be used in start-stop rocket engines instead of other less stable oxidizers.

公开(公告)号：CA2382467A1

公开(公告)日：2001-03-01

申请号：CA2382467

申请日：2000-08-18

Applicant: STANFORD RES INST INT

Inventor： PENWELL PAUL E ,  PETRIE MARK A ,  SCHMITT ROBERT J ,  BOTTARO JEFFREY C

IPC: A61K31/7072 ,  A61K31/7076 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/02 ,  C07H19/06 ,  C07H19/067 ,  C07H19/073 ,  C07H19/10 ,  C07H19/16 ,  C07H19/167 ,  C07H19/173 ,  C07H19/20 ,  A61K31/70

Abstract: Novel compounds are provided in the form of nucleoside pyrophosphate and triphosphate analogs. In these analogs, the pyrophosphate or triphosphate group is replaced with a moiety that is isosterically and electronically identical thereto, but is hydrolytically and enzymatically more stable. The compounds are useful as therapeutic agents, e.g., as antiviral agents, anticancer agents, metabolic moderators and the like. The invention also provides pharmaceutical compositions containing a compound of the invention as an active agent, and in addition provides methods of treating disease, including viral infections, cancer, bacterial infections, inflammatory and/or autoimmune diseases, and the like, by administering a compound of the invention to a patient in need of such treatment.

公开(公告)号：AU4075299A

公开(公告)日：1999-11-29

申请号：AU4075299

申请日：1999-05-11

Applicant: STANFORD RES INST INT

Inventor： BOTTARO JEFFREY C ,  SCHMITT ROBERT J ,  PENWELL PAUL E

IPC: C06B25/04 ,  C06B25/34 ,  C06C7/00 ,  C06C9/00 ,  C06D5/06 ,  C07D207/50 ,  C07D231/16 ,  C07D249/10 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D487/14

公开(公告)号：CA2128608A1

公开(公告)日：1993-08-19

申请号：CA2128608

申请日：1993-01-27

Applicant: STANFORD RES INST INT

Inventor： SCHMITT ROBERT J ,  BOTTARO JEFFREY C ,  PENWELL PAUL E ,  BOMBERGER DAVID C

IPC: C01B21/082 ,  C06B25/00 ,  C06B25/34 ,  C06B31/00 ,  C06B41/00 ,  C06D5/00 ,  C07C209/68 ,  C07C211/38 ,  C07C271/08 ,  C07C211/36 ,  C07C211/63 ,  C07C243/10

Abstract: 2128608 9316002 PCTABS00025 A method is disclosed for forming an ionically bonded dinitramide salt or acid useful as a stable oxidizer for solid fuel rocket propellant or explosive formulations is disclosed. The dinitramide salt is formed by the reaction of an N(alkoxycarbonyl)N-nitroamide and a nitronium-containing compound, at a temperature of from about +60 ·C to about -120 ·C, followed by contacting the reaction mass with a base to form the dinitramide salt, or an alcohol to form the corresponding dinitramidic acid. The N(alkoxycarbonyl)N-nitroamide may be formed by first mixing the corresponding alkylcarbamate with an anhydride of one or more 1-20 carbon organic acids, then adding nitric acid to the reaction mixture. If the salt of the N(alkoxycarbonyl)N-nitroamide is to be formed, a base is then added until the pH reaches about 7-10. The nitronium-containing reactant may be a covalently bonded compound containing an NO2-group; a nitryl halide; or a nitronium salt having the formula (NO2+)qX-q, where X is the anion of the nitronium salt and q = 1-2.