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1.发明公开N,N-DINITRAMIDE SALTS AS SOLUBILIZING AGENTS FOR BIOLOGICALLY ACTIVE AGENTS 审中-公开N，N-DINITRAMIDSALZE ALSLÖSUNGSVERMITTLERFÜRBIOLOGISCH AKTIVE MITTEL
公开(公告)号：EP1417153A4
公开(公告)日：2005-01-05
申请号：EP02756424
申请日：2002-07-09
Applicant: STANFORD RES INST INT
Inventor： BOTTARO JEFFREY C , PETRIE MARK A , PENWELL PAUL E , BOMBERGER DAVID C
IPC: A01N25/02 , A01N43/70 , A01N59/00 , A61K47/02 , A61K47/04 , A61K47/18 , A61K47/22 , A61K47/32 , A61K47/48 , A61K49/00 , C07C211/32 , C07D453/04 , C01B21/20 , C07C243/00
CPC classification number: C07D453/04 , A01N25/02 , A61K47/02 , A61K47/52 , C07C211/32 , C07C2603/32
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公开(公告)号：EP0833614A4
公开(公告)日：2001-07-11
申请号：EP96918456
申请日：1996-06-06
Applicant: STANFORD RES INST INT
Inventor： BOMBERGER DAVID C , CATZ PAUL G , SMEDLEY MARK I , STEARNS PAUL C
CPC classification number: B01J2/00 , A61K9/1652 , A61K9/1694 , A61K38/1774
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公开(公告)号：CA2224074A1
公开(公告)日：1996-12-19
申请号：CA2224074
申请日：1996-06-06
Applicant: STANFORD RES INST INT
Inventor： SMEDLEY MARK I , STEARNS PAUL C , CATZ PAUL G , BOMBERGER DAVID C
Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.
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公开(公告)号：CA2128608A1
公开(公告)日：1993-08-19
申请号：CA2128608
申请日：1993-01-27
Applicant: STANFORD RES INST INT
Inventor： SCHMITT ROBERT J , BOTTARO JEFFREY C , PENWELL PAUL E , BOMBERGER DAVID C
IPC: C01B21/082 , C06B25/00 , C06B25/34 , C06B31/00 , C06B41/00 , C06D5/00 , C07C209/68 , C07C211/38 , C07C271/08 , C07C211/36 , C07C211/63 , C07C243/10
Abstract: 2128608 9316002 PCTABS00025 A method is disclosed for forming an ionically bonded dinitramide salt or acid useful as a stable oxidizer for solid fuel rocket propellant or explosive formulations is disclosed. The dinitramide salt is formed by the reaction of an N(alkoxycarbonyl)N-nitroamide and a nitronium-containing compound, at a temperature of from about +60 ·C to about -120 ·C, followed by contacting the reaction mass with a base to form the dinitramide salt, or an alcohol to form the corresponding dinitramidic acid. The N(alkoxycarbonyl)N-nitroamide may be formed by first mixing the corresponding alkylcarbamate with an anhydride of one or more 1-20 carbon organic acids, then adding nitric acid to the reaction mixture. If the salt of the N(alkoxycarbonyl)N-nitroamide is to be formed, a base is then added until the pH reaches about 7-10. The nitronium-containing reactant may be a covalently bonded compound containing an NO2-group; a nitryl halide; or a nitronium salt having the formula (NO2+)qX-q, where X is the anion of the nitronium salt and q = 1-2.
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公开(公告)号：CA2224074C
公开(公告)日：2009-09-08
申请号：CA2224074
申请日：1996-06-06
Applicant: STANFORD RES INST INT
Inventor： STEARNS PAUL C , CATZ PAUL G , BOMBERGER DAVID C , SMEDLEY MARK I
Abstract: Method and system of producing microparticles loaded with biologically activ e drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixi ng chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles . The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.
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Patent Agency Ranking
公开(公告)号：AT353631T
公开(公告)日：2007-03-15
申请号：AT96918456
申请日：1996-06-06
Applicant: STANFORD RES INST INT
Inventor： BOMBERGER DAVID C , CATZ PAUL G , SMEDLEY MARK I , STEARNS PAUL C
Abstract: Method and system of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug. The system includes a first mixing chamber, in which the emulsion is created, having a first port for introducing the drug/polymer solution, and a second port angled substantially perpendicular to the first port for introducing the emulsifier. A second mixing chamber adjacent to the first mixing chamber receives the emulsion and either contains a cross-linking agent or receives a stream of a cross-linking agent to solidify the microparticles. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.
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公开(公告)号：CA2249404A1
公开(公告)日：1997-09-25
申请号：CA2249404
申请日：1997-03-19
Applicant: JAYAWEERA INDIRA , BOMBERGER DAVID C , ROSS DAVID J , LEIF ROALD N , STANFORD RES INST INT
Inventor： JAYAWEERA INDIRA , ROSS DAVID S , LEIF ROALD N , BOMBERGER DAVID C
IPC: A62D3/00 , A62D3/20 , A62D3/34 , A62D3/35 , A62D3/36 , A62D3/38 , A62D101/02 , A62D101/04 , A62D101/06 , A62D101/22 , A62D101/24 , A62D101/26 , A62D101/28 , A62D101/40 , B01J3/00 , B01J19/00 , B09B3/00 , C02F1/72 , C02F11/08
Abstract: This invention relates to a process for the decomposition of material selected from halogenated organic compounds, to compounds which are environmentally acceptable, or are amenable to further degradation by conventional disposal systems to produce environmentally acceptable products, which process comprises: (a) conveying an aqueous solution or an aqueous slurry of material into a reaction zone capable of withstanding the temperatures and pressures of decomposition of the material; (b) contacting the material in the reaction zone with aqueous sodium carbonate as a reactant in an amount effective to decompose the material under hydrothermal oxidation conditions of between about 300 and 600 ~C and a pressure of between about 10 and 400 atmospheres for between 0.01 and 120 min wherein the specific reactant, a carbonate such as sodium carbonate, at the reaction conditions is present at about 10 % or less as a water-soluble salt as compared to the solubility of the salt at ambient conditions wherein the specific reactant is essentially present as a solid and the oxidation occurs under heterogeneous conditions, wherein the process occurs in the presence of a gaseous oxidant wherein said oxidant is present in an amount of between about 0.01 and 50 % by weight of the material; (c) producing about 99 % or greater of the decomposition of the material, or 99 % or greater conversion of the material to compounds which are environmentally acceptable or to compounds which are amendable to further degradation; and (d) optionally degrading further the compounds produced in step (c) by reaction to environmentally acceptable products. Preferably, the specific reactant is sodium carbonate and the oxidant is oxygen or air. Preferably, the halogenated organic compound is selected from polychlorobiphenyl, polybromobiphenyl mono-chlorobenzodioxin or polychlorobenzodioxin compounds.
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公开(公告)号：ES2281084T3
公开(公告)日：2007-09-16
申请号：ES96918456
申请日：1996-06-06
Applicant: STANFORD RES INST INT
Inventor： BOMBERGER DAVID C , CATZ PAUL G , SMEDLEY MARK I , STEARNS PAUL C
Abstract: METODO Y SISTEMA PARA PRODUCIR MICROPARTICULAS CARGADAS CON FARMACOS BIOLOGICAMENTE ACTIVOS, INCLUYENDO PROTEINAS TALES COMO ICAM-1, PARA LA LIBERACION CONTROLADA DE LOS FARMACOS EN LAS FOSAS NASALES. EL METODO INCLUYE LA INTRODUCCION DE UN FARMACO/SOLUCION DE POLIMERO DE ALIMENTACION Y UN EMULSIVO EN UNA PRIMERA CAMARA DE MEZCLA PARA CREAR UNA EMULSION, MEZCLANDO A CONTINUACION UN AGENTE DE ENTRELAZADO JUNTO CON LA EMULSION BAJO CONDICIONES CONTROLADAS PARA CREAR MICROPARTICULAS CARGADAS CON EL FARMACO. EL SISTEMA INCLUYE UNA PRIMERA CAMARA DE MEZCLA, EN LA QUE SE CREA LA EMULSION, QUE POSEE UN PRIMER PUERTO PARA INTRODUCIR EL FARMACO/SOLUCION DE POLIMERO, Y UN SEGUNDO PUERTO EN UN ANGULO PRACTICAMENTE PERPENDICULAR AL PRIMERO PARA INTRODUCIR EL EMULSIVO. UNA SEGUNDA CAMARA DE MEZCLA, ADYACENTE A LA PRIMERA CAMARA, RECIBE LA EMULSION QUE CONTIENE UN AGENTE DE ENTRELAZADO O QUE RECIBE UN CHORRO DE UN AGENTE DE ENTRECRUZAMIENTO PARA SOLIDIFICAR LAS MICROPARTICULAS. LAS MICROPARTICULAS FORMADAS SE FILTRAN Y SE DESAGREGAN PARA FORMAR MICROPARTICULAS INDIVIDUALES QUE PUEDEN ENTONCES SER FORMULADAS PARA SU ADMINISTRACION EN LAS FOSAS NASALES.
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公开(公告)号：CA2453179A1
公开(公告)日：2003-01-23
申请号：CA2453179
申请日：2002-07-09
Applicant: STANFORD RES INST INT
Inventor： BOTTARO JEFFREY C , PETRIE MARK A , PENWELL PAUL E , BOMBERGER DAVID C
IPC: A01N25/02 , A01N43/70 , A01N59/00 , A61K47/02 , A61K47/04 , A61K47/18 , A61K47/22 , A61K47/32 , A61K47/48 , A61K49/00 , C07C211/32 , C07D453/04 , C07C243/00 , A61K31/16 , C07C243/02
Abstract: A method is provided for enhancing the solubility of an ionizable compound i n a lipophilic medium by admixing the compound with an effective solubility- enhancing amount of an N,N-dinitramide salt. The ionizable compound, upon ionization, gives rise to a biologically active cationic species that ionically associates with the N,N-dinitramide anion N(NO2)2 following admixture with the N,N-dinitramide salt. The biologically active cationic species may be a pharmacologically active cation, in which case the method i s useful for enhancing the penetration of the blood-brain barrier by the pharmacologically active cation. In other embodiments, the ionizable compoun ds are medical imaging or diagnostic agents, or agricultural agents such as pesticides. Salts of biologically active cations and N,N-dinitramide ion are also provided as novel compositions of matter.
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公开(公告)号：AT194503T
公开(公告)日：2000-07-15
申请号：AT97916849
申请日：1997-03-19
Applicant: STANFORD RES INST INT
Inventor： ROSS DAVID S , JAYAWEERA INDIRA , BOMBERGER DAVID C , LEIF ROALD N
IPC: A62D3/00 , A62D3/20 , A62D3/34 , A62D3/35 , A62D3/36 , A62D3/38 , A62D101/02 , A62D101/04 , A62D101/06 , A62D101/22 , A62D101/24 , A62D101/26 , A62D101/28 , A62D101/40 , B01J3/00 , B01J19/00 , B09B3/00 , C02F1/72 , C02F11/08
Abstract: This invention relates to a process for the decomposition of material selected from halogenated organic compounds, to compounds which are environmentally acceptable, or are amenable to further degradation by conventional disposal systems to produce environmentally acceptable products, which process comprises: (a) conveying an aqueous solution or an aqueous slurry of material into a reaction zone capable of withstanding the temperatures and pressures of decomposition of the material; (b)contacting the material in the reaction zone with aqueous sodium carbonate as a reactant in an amount effective to decompose the material under hydrothermal oxidation conditions of between about 300 DEG and 400 DEG C. and a pressure of between about 20 and 400 atmospheres for between 0.01 and 120 min wherein the sodium carbonate at the reaction conditions is present at about 10% or less as a water soluble salt as compared to the solubility of the salt at ambient conditions, wherein the process occurs in the presence of a gaseous oxidant wherein said oxidant is present in an amount of between about 0.01 and 50% by weight of the material; (c) producing about 99% or greater of the decomposition of the material, or 99% or greater conversion of the material to compounds which are environmentally acceptable or to compounds which are amendable to further degradation; and (d) optionally degrading further the compounds produced in step (c) by reaction to environmentally acceptable products. Preferably, the specific reactant is sodium carbonate and the oxidant is oxygen or air. Preferably, the halogenated organic compound is selected from polychlorobiphenyl, polybromobiphenyl or chlorobenzodioxin compounds.
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