公开(公告)号：WO2010014827A2

公开(公告)日：2010-02-04

申请号：PCT/US2009/052277

申请日：2009-07-30

Applicant: STC.UNM ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

Inventor： SMYTH, Hugh, D.C. ,  DONOVAN, Martin

IPC: A61K9/14

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 μm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

Abstract translation: 干粉吸入器可以包括配置成容纳包含载体颗粒和工作剂颗粒的制剂的药物室，构造成将工作剂颗粒流向使用者的接口管和靠近接口管的保持构件。 保持构件的尺寸和布置被设计成防止基本上所有的载体颗粒流向使用者，同时允许工作剂颗粒流向使用者。 吸入器可以包括包含用于将工作剂递送到患者的肺部系统的载体颗粒的制剂。 载体颗粒的平均筛子直径可以大于约500μm。 载体颗粒可以是聚苯乙烯，PTFE，硅玻璃和硅胶或玻璃之一。

公开(公告)号：WO2011112756A3

公开(公告)日：2011-09-15

申请号：PCT/US2011/027797

申请日：2011-03-09

Applicant: STC.UNM ,  SELVAM, Parthiban ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

Inventor： SELVAM, Parthiban ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

IPC: B05B7/14 ,  B05B7/24 ,  B05B7/02 ,  B05B15/00

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

公开(公告)号：EP2328556A2

公开(公告)日：2011-06-08

申请号：EP09803599.1

申请日：2009-07-30

Applicant: STC.UNM

Inventor： SMYTH, Hugh, D.C. ,  DONOVAN, Martin

IPC: A61K9/14

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 μm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

公开(公告)号：EP2544825A2

公开(公告)日：2013-01-16

申请号：EP11754041.9

申请日：2011-03-09

Applicant: STC.UNM

Inventor： SELVAM, Parthiban ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

IPC: B05B7/14 ,  B05B7/24 ,  B05B7/02 ,  B05B15/00

CPC classification number: B05B7/144 ,  A61M15/0028 ,  A61M15/0065 ,  A61M15/009 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2205/0238 ,  B05B12/36 ,  B05B13/0207

Abstract: A device for coating dry powder microparticles onto a surface may include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.