公开(公告)号：EP2544825A2

公开(公告)日：2013-01-16

申请号：EP11754041.9

申请日：2011-03-09

Applicant: STC.UNM

Inventor： SELVAM, Parthiban ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

IPC: B05B7/14 ,  B05B7/24 ,  B05B7/02 ,  B05B15/00

CPC classification number: B05B7/144 ,  A61M15/0028 ,  A61M15/0065 ,  A61M15/009 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2205/0238 ,  B05B12/36 ,  B05B13/0207

Abstract: A device for coating dry powder microparticles onto a surface may include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

公开(公告)号：EP2328556A2

公开(公告)日：2011-06-08

申请号：EP09803599.1

申请日：2009-07-30

Applicant: STC.UNM

Inventor： SMYTH, Hugh, D.C. ,  DONOVAN, Martin

IPC: A61K9/14

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 μm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

公开(公告)号：WO2011060334A2

公开(公告)日：2011-05-19

申请号：PCT/US2010/056628

申请日：2010-11-12

Applicant: STC.UNM ,  SMYTH, Hugh, D.C. ,  SELVAM, Parthiban ,  TRUMAN, Charles, Randall

Inventor： SMYTH, Hugh, D.C. ,  SELVAM, Parthiban ,  TRUMAN, Charles, Randall

CPC classification number: A61M15/0028 ,  A61M11/003 ,  A61M15/0031 ,  A61M15/0038 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2206/16

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

Abstract translation: 一种干粉吸入器，包括限定用于接收一剂粉末状药剂的腔室的壳体，与腔室流体连通的吸入端口，至少一个气流入口，所述至少一个气流入口提供腔室与外部之间的流体连通 壳体中的颤动元件以及腔室中的颤动元件并且与一定剂量的粉状药剂相关联。 颤动元件具有靠近至少一个气流入口的张紧远端和与远端相对且在入口下游的自由近端。 颤振元件构造成响应于通过腔室的气流而振动并且雾化剂量的粉状药物。

公开(公告)号：EP2498848A2

公开(公告)日：2012-09-19

申请号：EP10830835.4

申请日：2010-11-12

Applicant: STC.UNM

Inventor： SMYTH, Hugh, D.C. ,  SELVAM, Parthiban ,  TRUMAN, Charles, Randall

IPC: A61M15/00 ,  A61M11/02

CPC classification number: A61M15/0028 ,  A61M11/003 ,  A61M15/0031 ,  A61M15/0038 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2206/16

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

公开(公告)号：EP2470167A2

公开(公告)日：2012-07-04

申请号：EP10815900.5

申请日：2010-08-27

Applicant: STC.UNM

Inventor： SMYTH, Hugh, D.C. ,  DONOVAN, Martin, J.

IPC: A61K9/28 ,  A61K9/14 ,  A61K9/12

CPC classification number: A61K9/0075 ,  A61K9/14 ,  A61K31/58

Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.

公开(公告)号：WO2011031564A2

公开(公告)日：2011-03-17

申请号：PCT/US2010/047043

申请日：2010-08-27

Applicant: STC.UNM ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin, J.

Inventor： SMYTH, Hugh, D.C. ,  DONOVAN, Martin, J.

IPC: A61K9/28 ,  A61K9/14 ,  A61K9/12

CPC classification number: A61K9/0075 ,  A61K9/14 ,  A61K31/58

Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.

Abstract translation: 将粉末状药剂涂布在用于干粉吸入器的载体颗粒上的方法的方法可以包括将超声能量施加到附聚的粉末状药剂以将药剂的颗粒分解和雾化成具有所需平均粒径的颗粒，以及涂覆 至少一个具有所需量的药物的解聚集和雾化颗粒的载体颗粒。

公开(公告)号：WO2010014827A2

公开(公告)日：2010-02-04

申请号：PCT/US2009/052277

申请日：2009-07-30

Applicant: STC.UNM ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

Inventor： SMYTH, Hugh, D.C. ,  DONOVAN, Martin

IPC: A61K9/14

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 μm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

Abstract translation: 干粉吸入器可以包括配置成容纳包含载体颗粒和工作剂颗粒的制剂的药物室，构造成将工作剂颗粒流向使用者的接口管和靠近接口管的保持构件。 保持构件的尺寸和布置被设计成防止基本上所有的载体颗粒流向使用者，同时允许工作剂颗粒流向使用者。 吸入器可以包括包含用于将工作剂递送到患者的肺部系统的载体颗粒的制剂。 载体颗粒的平均筛子直径可以大于约500μm。 载体颗粒可以是聚苯乙烯，PTFE，硅玻璃和硅胶或玻璃之一。

公开(公告)号：WO2011112756A3

公开(公告)日：2011-09-15

申请号：PCT/US2011/027797

申请日：2011-03-09

Applicant: STC.UNM ,  SELVAM, Parthiban ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

Inventor： SELVAM, Parthiban ,  SMYTH, Hugh, D.C. ,  DONOVAN, Martin

IPC: B05B7/14 ,  B05B7/24 ,  B05B7/02 ,  B05B15/00

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.