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    Polymer microfilters and methods of manufacturing the same
    91.
    发明专利
    Polymer microfilters and methods of manufacturing the same 未知

    公开(公告)号：AU2011248929B2

    公开(公告)日：2015-11-05

    申请号：AU2011248929

    申请日：2011-04-01

    Applicant: CREATV MICROTECH INC

    Inventor： MAKAROVA OLGA V ,  TANG CHA-MEI ,  AMSTUTZ PLATTE T

    IPC: B01D39/00

    Abstract: A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate.

    ANTI-SCATTER GRIDS AND COLLIMATOR DESIGNS, AND THEIR MOTION,FABRICATION AND ASSEMBLY
    92.
    发明专利
    ANTI-SCATTER GRIDS AND COLLIMATOR DESIGNS, AND THEIR MOTION,FABRICATION AND ASSEMBLY 未知

    公开(公告)号：CA2437454A1

    公开(公告)日：2002-08-22

    申请号：CA2437454

    申请日：2002-02-01

    Applicant: CREATV MICROTECH INC

    Inventor： MAKAROVA OLGA ,  TANG CHA-MEI

    IPC: G21K1/02 ,  G21K1/06 ,  G21K1/00 ,  G21K4/00 ,  G01T1/00 ,  G01T7/00

    Abstract: Grids (30) and collimators, for use with electromagnetic energy emitting devices (61), include at least a metal layer that is formed, for example, by electroplating/electroforming or casting. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls (32). Each of the solid integrated walls extends from the top to bottom surface and has a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings (31) extending entirely throu gh the layer. At least some of the walls (32) also can include projections extending into the respective openings formed by the walls (32). The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a directi on along an edge of the grid (30) is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid (30) at any distanc e from the edge. Methods to fabricate these grids (30) using copper, lead, nickel, gold, any other electroplating/electroforming materials or low melti ng temperature metals are described.

    FREESTANDING HIGH-ASPECT-RATIO GOLD MASKS FOR LOW-ENERGY, PHASE-BASED X-RAY MICROSCOPY
    93.
    发明公开
    FREESTANDING HIGH-ASPECT-RATIO GOLD MASKS FOR LOW-ENERGY, PHASE-BASED X-RAY MICROSCOPY 审中-公开

    公开(公告)号：US20240312665A1

    公开(公告)日：2024-09-19

    申请号：US18377523

    申请日：2023-10-06

    Applicant: Creatv MicroTech, Inc.

    Inventor： Olga V. Makarova ,  Ralu Divan ,  Nicolaie Moldovan ,  David A. Czaplewski ,  Cha-Mei Tang

    IPC: G21K1/10 ,  G21K7/00

    CPC classification number: G21K1/10 ,  G21K7/00

    Abstract: High-resolution, X-ray phase contrast microscopy, a key technique with promising potential in biomedical imaging and diagnostics, is based on narrow-slit high-aspect-ratio gold gratings. We present the development, fabrication details, and experimental testing of the freestanding 10-μm-thick gold membrane masks with an array of 0.9-1.5 □m void slit apertures for a novel low-energy X-ray microscope. The overall mask size is 4 mm×4 mm, with a grating pitch of 7.5 □m, 6.0-6.6-□m-wide gold bars are supported by 3-□m-wide crosslinks at 400 □m intervals. The fabrication process is based on gold electroplating into a silicon mold coated with various thin films to form a voltage barrier, plating base, and sacrificial layer, followed by the mold removal to obtain the freestanding gold membrane with void slit apertures. We discuss key aspects for the materials and processes, including gold structures homogeneity, residual stresses, and prevention of collapsing of the grid elements. We further demonstrate the possibility to obtain high-resolution, high contrast 2D images of biological samples using an incoherent, rotating anode X-ray tube.

    USE OF CIRCULATING TUMOR CELL MITOTIC INDEX IN CANCER STRATIFICATION AND DIAGNOSTICS
    95.
    发明申请
    USE OF CIRCULATING TUMOR CELL MITOTIC INDEX IN CANCER STRATIFICATION AND DIAGNOSTICS 有权

    公开(公告)号：US20220034888A1

    公开(公告)日：2022-02-03

    申请号：US17503872

    申请日：2021-10-18

    Applicant: CREATV MICROTECH INC.

    Inventor： Daniel ADAMS ,  Cha-Mei TANG

    IPC: G01N33/574 ,  G01N33/50

    Abstract: Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.

    Fabrication of Microfilters and Nanofilters and Their Applications
    100.
    发明申请
    Fabrication of Microfilters and Nanofilters and Their Applications 审中-公开

    公开(公告)号：US20190262778A1

    公开(公告)日：2019-08-29

    申请号：US16265305

    申请日：2019-02-01

    Applicant: Creatv MicroTech, Inc.

    Inventor： Cha-Mei Tang ,  Olga Makarova

    IPC: B01D67/00 ,  A61M1/34 ,  B01D69/12 ,  C12M1/00 ,  B01D71/46 ,  B01D71/64

    Abstract: Micro- and nanofilters with precision pore sizes and pore layout have applications in many fields including capturing circulating tumor cells and fetal cells in blood, water treatment, pathogen detection in water, etc. Methods to fabricate micro- and nanofilters not using track etching or reactive ion etching are provided, allowing easy fabrication of single layer or stack of films simultaneously, and/or stack of films on rolls. Microfilter can be made using one or more layers of material. Invention enables mass production of microfilters with lithographic quality at low cost. Isolation, enumeration and characterization of circulating tumor cells using microfilters provides (i) guides to cancer treatment selection and personalize dosage, (ii) low cost monitoring for treatment response, disease progression and recurrence, (iii) assessment of pharmacodynamic effects, (iv) information on mechanisms of resistance to therapy, and (v) cancer staging. Microfabrication methods are also applicable to fabrication of any free standing patterned polymeric films.

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