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    Nucleic acid molecules and uses thereof
    91.
    发明授权
    Nucleic acid molecules and uses thereof 有权

    公开(公告)号：US11866704B2

    公开(公告)日：2024-01-09

    申请号：US17247265

    申请日：2020-12-06

    Applicant: Macau University of Science and Technology

    Inventor： Zhi-Hong Jiang ,  Kai-Yue Cao ,  Yu Pan ,  Tong-Meng Yan

    IPC: C12N15/113

    CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12N2310/32

    Abstract: A method of treating a subject suffering from cancer comprising a step of administering an effective amount of a group of double-stranded RNA molecules to the subject, wherein the RNA molecule is isolated or derived from a bacteria of the genus Escherichia. A method of inhibiting growth or proliferation of cancer cells comprising a step of contacting said cells with said RNA molecule; and a pharmaceutical composition for treating cancer comprising said RNA molecule and a pharmaceutically tolerable excipient. Also a double-stranded RNA molecule and a recombinant vector comprising the double-stranded RNA molecule.

    Method of isolating sphingolipids from cordyceps and their use
    93.
    发明授权
    Method of isolating sphingolipids from cordyceps and their use 有权

    公开(公告)号：US11357806B2

    公开(公告)日：2022-06-14

    申请号：US15131218

    申请日：2016-04-18

    Applicant: Macau University of Science and Technology

    Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Jia-Ning Mi ,  Junping Kou ,  Yuwei Han ,  Yingqiong Xu

    IPC: A61K36/068 ,  A61K31/133 ,  A61K31/164 ,  A61K31/688 ,  G01N30/34 ,  G01N30/72 ,  B01D15/42 ,  C12Q1/04 ,  G01N33/92 ,  G01N30/00 ,  G01N30/02

    Abstract: A method of isolating at least one sphingolipid portion selected from a sphingoid base portion, a ceramide portion, a glycosphingolipid portion or a phosphosphingolipid portion from Cordyceps, in particular from wild-type Cordyceps, allows for obtaining sphingolipid portions having an increased amount of one of sphingoid bases, ceramides, glycosphingolipids or phosphosphingolipids. The sphingolipid portions isolated contained significant amounts of sphingolipids not reported so far, and possess exceptional immunosuppressive activities. A method of treating a subject suffering from an inflammatory disease like an autoimmune disease or an allergic disease includes administering sphingolipids isolated from Cordyceps, in particular from wild-type Cordyceps. A method of treating a subject suffering from an inflammatory disease includes administering certain sphingolipids to the subject. Still further in accordance with the present invention is a composition, in particular a pharmaceutical composition comprising at least one sphingolipid portion.

    Multimodal Self-Paced Learning with a Soft Weighting Scheme for Robust Classification of Multiomics Data
    94.
    发明申请
    Multimodal Self-Paced Learning with a Soft Weighting Scheme for Robust Classification of Multiomics Data 有权

    公开(公告)号：US20220027786A1

    公开(公告)日：2022-01-27

    申请号：US16947234

    申请日：2020-07-24

    Applicant: Macau University of Science and Technology

    Inventor： Yong LIANG ,  Ziyi YANG

    IPC: G06N20/00 ,  G06K9/62 ,  G06F17/16

    Abstract: A robust multimodal data integration method, termed the SMSPL technique, aimed at simultaneously predicting subtypes of cancers and identifying potentially significant multiomics signatures, is provided. The SMSPL technique leverages linkages among different types of data to interactively recommend high-confidence training samples during classifier training. Particularly, a new soft weighting scheme is adopted to assign weights to training samples of each type, thus more faithfully reflecting latent importance of samples in self-paced learning. The SMSPL technique iterates between calculating the sample weights from training loss values and minimizing weighted training losses for classifier updating, allowing the classifiers to be efficiently trained. In classifying a test sample, outputs of the trained classifiers are integrated to yield a class label by solving an optimization problem for minimizing a sum of classifier losses in selecting a candidate class label, making the SMSPL technique more accruable to discriminate equivocal samples.

    Method and device for information system access authentication
    96.
    发明授权
    Method and device for information system access authentication 有权

    公开(公告)号：US10530582B2

    公开(公告)日：2020-01-07

    申请号：US15032182

    申请日：2014-10-10

    Applicant: Singou Technology Ltd. ,  Macau University of Science and Technology

    Inventor： Chi Tin Hon ,  Chan Heng Tam ,  Tai-Hua Ma

    IPC: H04L9/32 ,  H04L29/06 ,  H04W12/06 ,  H04W12/00

    Abstract: A method and a device for information system access authentication are disclosed. The method includes: performing anonymous authentication to a random verification code generated according to a login request for accessing an information system of a client, and authenticating acquired user name and password information when the anonymous authentication is successful. The device includes an verification code authentication module and a user name and password authentication module connected to the verification code authentication module, wherein the verification code authentication module is configured to perform anonymous authentication to a random verification code generated according to a login request for accessing an information system of client; and the user name and password authentication module is configured to authenticate acquired user name and password information when the anonymous authentication is successful. The present disclosure uses a two-stage and two-factor authentication method such that the security of the login information is improved without increasing the complexity of the user's login.

    Multi cluster tool system and a method of controlling a multi tool cluster system
    97.
    发明授权
    Multi cluster tool system and a method of controlling a multi tool cluster system 有权

    公开(公告)号：US10520914B2

    公开(公告)日：2019-12-31

    申请号：US15268851

    申请日：2016-09-19

    Applicant: Macau University of Science and Technology

    Inventor： Naiqi Wu ,  Fajun Yang ,  Liping Bai ,  Mengchu Zhou ,  Zhiwu Li

    IPC: G05B19/29 ,  G05B19/418

    Abstract: A system and method of controlling a multi cluster tool system configured to process a semiconductor product includes a plurality of cluster tools arranged adjacent each other, a buffer module positioned between a pair of cluster tools, each cluster tool including a plurality of processing modules and a robot, the method of controlling a multi cluster tool system including receiving a plurality of system parameters from a user interface, wherein the system parameters correspond to one or more processing steps in a system cycle, wherein the system cycle is a cycle of processing the semiconductor product, determining a system schedule for defining the system cycle for processing a semiconductor product, the system schedule providing robot waiting times for each robot of each cluster tool, controlling, via a controller, the operation of each robot of each cluster tool based on the determined schedule.

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